Metabolic Niches: MALDI Imaging Reveals Lipidomic Heterogeneity in the Human Heart. [PDF]
J Am Soc Mass SpectromOsumi KM +4 more
europepmc +1 more source
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Chemical Derivatization Strategies for Expanding Small Biomolecule Analysis by MALDI-MS. [PDF]
MetabolitesHu X, Wang Q, Lin Y, Wan J.
europepmc +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley +1 more source
Refined on-tissue chemical derivatization expands MALDI-MSI capabilities for spatial metabolomics of mammalian organs and metastatic tumors using EDC and 4-APEBA. [PDF]
Cancer Cell IntFecke A +9 more
europepmc +1 more source
Ion Activation Methods for Top‐Down Proteomics
Mass Spectrometry Reviews, EarlyView.ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley +1 more source
Development and validation of the first species-specific MALDI-TOF MS main spectra profile database for rapid identification of Aeromonas schubertii associated with white nodular disease in freshwater fish. [PDF]
Vet WorldMursalim MF +5 more
europepmc +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source
Microbial diversity and adaptation Strategies in the nunataks of Western Dronning Maud Land, Antarctica. [PDF]
Front MicrobiolSingh P, Singh SM.
europepmc +1 more source