Results 51 to 60 of about 104,411 (250)

Enhanced Operational Stability of Carbene‐Metal‐Amide Organic Light‐Emitting Diodes by Reducing Electron Accumulation on the Emitter

Advanced Optical Materials, EarlyView.
Carbene‐metal‐amide (CMA) organic LEDs suffer from poor stability despite submicrosecond excited‐state lifetimes. Here, we show that electron accumulation on CMA emitters triggers bond cleavage, while poor electron transport amplifies OLED instability.
Rishabh Saxena, J. Terence Blaskovits, Alexander C. Brannan, Alexander Romanov, Seah Ling Kuan, Hans Joachim Räder, Denis Andrienko, Paul W. M. Blom, Gert‐Jan A. H. Wetzelaer   +8 more
wiley   +1 more source

MALDI imaging mass spectrometry: statistical data analysis and current computational challenges

BMC Bioinformatics, 2012
Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) imaging mass spectrometry, also called MALDI-imaging, is a label-free bioanalytical technique used for spatially-resolved chemical analysis of a sample.
Alexandrov Theodore
doaj   +1 more source

Cluster-Assembled Nanoporous Super-Hydrophilic Smart Surfaces for On-Target Capturing and Processing of Biological Samples for Multi-Dimensional MALDI-MS

Molecules, 2022
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) on cluster-assembled super-hydrophilic nanoporous titania films deposited on hydrophobic conductive-polymer substrates feature a unique combination of surface properties that ...
Emanuele Barborini, Giacomo Bertolini, Monica Epifanio, Alexander Yavorskyy, Simone Vinati, Marc Baumann   +5 more
doaj   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

A New Method for Extraction and Analysis of Ricin Samples through MALDI-TOF-MS/MS

Toxins, 2019
We report for the first time the efficient use of accelerated solvent extraction (ASE) for extraction of ricin to analytical purposes, followed by the combined use of sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), Matrix-assisted ...
Roberto B. Sousa, Keila S. C. Lima, Caleb G. M. Santos, Tanos C. C. França, Eugenie Nepovimova, Kamil Kuca, Marcos R. Dornelas, Antonio L. S. Lima   +7 more
doaj   +1 more source

An easy adjustment of instrument settings (‘Peak MALDI’) improves identification of organisms by MALDI-ToF mass spectrometry

Scientific Reports, 2023
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF MS) is a mature technology with ‘auto-execute’ instrument settings and peak processing parameters tailored for rapid bacterial identification.
Christopher M. Nellessen, David B. Nehl
doaj   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Identification of Mycobacterium abscessus using the peaks of ribosomal protein L29, L30 and hemophore-related protein by MALDI-MS proteotyping

Scientific Reports
Mycobacteroides (Mycobacterium) abscessus, which causes a variety of infectious diseases in humans, is becoming detected more frequently in clinical specimens as cases are spreading worldwide. Taxonomically, M.
Satomi Takei, Kanae Teramoto, Yuji Sekiguchi, Hiroaki Ihara, Mari Tohya, Shinichi Iwamoto, Koichi Tanaka, Abdullah Khasawneh, Yuki Horiuchi, Shigeki Misawa, Toshio Naito, Teruo Kirikae, Tatsuya Tada, Yoko Tabe   +13 more
doaj   +1 more source

Isolation and identification of Wickerhamiella tropicalis from blood culture by MALDI-MS

Frontiers in Cellular and Infection Microbiology
Wickerhamiella is a genus of budding yeast that is mainly isolated from environmental samples, and 40 species have been detected. The yeast isolated from human clinical samples usually only contain three species: W. infanticola, W.
Satomi Takei, Satomi Takei, Kanae Teramoto, Kanae Teramoto, Junya Fujimura, Megumi Fujiwara, Mai Suzuki, Yukiko Fukui, Yuji Sekiguchi, Takaaki Kawakami, Masayoshi Chonan, Mitsuru Wakita, Yuki Horiuchi, Takashi Miida, Toshio Naito, Toshio Naito, Teruo Kirikae, Teruo Kirikae, Tatsuya Tada, Yoko Tabe, Yoko Tabe   +20 more
doaj   +1 more source

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, EarlyView.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source