Results 81 to 90 of about 104,411 (250)

Assessment of matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification and biotyping of the pathogenic oomycete Pythium insidiosum

International Journal of Infectious Diseases, 2018
Objective: Pythiosis is a life-threatening infectious disease caused by the oomycete Pythium insidiosum. The disease has been increasingly reported worldwide. Most patients with pythiosis undergo surgical removal of an infected organ.
Theerapong Krajaejun, Tassanee Lohnoo, Paisan Jittorntam, Atthapol Srimongkol, Yothin Kumsang, Wanta Yingyong, Thidarat Rujirawat, Onrapak Reamtong, Suthee Mangmee   +8 more
doaj   +1 more source

Ultrastable Self‐Cross‐linkable Electro‐Optic Materials Based on a Bisanthracene Scaffold

Advanced Electronic Materials, EarlyView.
A novel bisanthracene‐based self‐cross‐linkable electro‐optic chromophore (TD2) is developed. TD2 exhibits a high r33 of 141 pm/V and a cross‐linked Tg up to 195 °C, retaining 99.75% of its initial EO response after 500 h at 85 °C, showing record‐high thermal stability for single‐molecule self‐cross‐linking EO materials.
Xingtao Wang, Zhifan Liu, Qinghua Yang, Jiayan Xu, Lin Li, Fenggang Liu, Shengyu Cong   +6 more
wiley   +1 more source

Comparison of Vacuum MALDI and AP-MALDI Platforms for the Mass Spectrometry Imaging of Metabolites Involved in Salt Stress in Medicago truncatula

Frontiers in Plant Science, 2018
Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) is routinely used to determine the spatial distributions of various biomolecules in tissues.
Caitlin Keller, Junko Maeda, Dhileepkumar Jayaraman, Sanhita Chakraborty, Michael R. Sussman, Jeanne M. Harris, Jean-Michel Ané, Jean-Michel Ané, Lingjun Li, Lingjun Li   +9 more
doaj   +1 more source

Controlling Self‐Doping in Conjugated Polyelectrolyte Copolymers to Vary the Threshold Voltage in OECTs

Advanced Electronic Materials, EarlyView.
Two series of self‐doped conjugated polyelectrolytes are synthesized from a non‐self‐dopable building block 3MEEET and a self‐dopable building‐block 3HOT−[TMA+] or 3HOT−[SO3H] enabling precise control over the degree of self‐doping, which in turn directly governs the threshold voltage (VT) in OECTs over a wide range of 700 mV.
Julian Hungenberg, Andreas W. Erhardt, Adrian Hochgesang, John Mohanraj, Lys Sprenger, Sahar Salehi, Christopher R. McNeill, Mukundan Thelakkat   +7 more
wiley   +1 more source

De Novo Discovery of Nonstandard Thioisoindole‐Bridged Bicyclic Peptides Targeting Traf2‐ and NCK‐Interacting Kinase

Angewandte Chemie, EarlyView.
An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang, Alexander A. Vinogradov, Keisuke Hamada, Yin Sun, Toru Sengoku, Hiroaki Suga   +5 more
wiley   +2 more sources

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Heterobimetallic Janus Catalysts for the One‐Pot Synthesis of Polar‐Apolar Block Copolymers

Angewandte Chemie, EarlyView.
Heterobimetallic Janus catalysts act as bifunctional initiators, combining two distinct polymerisation mechanisms in one pot to deliver well‐defined apolar‐polar block copolymers. Combining Earth abundant Ti and Al catalysts for respective α‐olefin and lactone polymerisation, the orthogonal activity is enabled by unprecedented initiation from a Ti ...
Raju Chambenahalli, Gary S. Nichol, Jennifer A. Garden   +2 more
wiley   +2 more sources

Comparison of biomarker based Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) and conventional methods in the identification of clinically relevant bacteria and yeast

BMC Microbiology, 2017
Background MALDI-TOF MS is an analytical method that has recently become integral in the identification of microorganisms in clinical laboratories. It relies on databases that majorly employ pattern recognition or fingerprinting.
Ali Kassim, Valentin Pflüger, Zul Premji, Claudia Daubenberger, Gunturu Revathi   +4 more
doaj   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Mechanical Caging of Nucleic Acids Enabled by Light‐Activated Synthetic Molecular Motors

Angewandte Chemie, EarlyView.
A synthetic light‐driven molecular motor imposes mechanical constraints on nucleic acids, enabling “mechanical caging” as a new mode to regulate DNA structure and function through mechanical input rather than chemical masking. ABSTRACT Control over nucleic acid activity is central to biotechnology and therapeutic development.
Yuchen Ma, Erika McCarthy, N. Sanjeeva Murthy, Cameron McGovern, Zhenyu Han, Şölen Ekesan, Subhajit Nandi, Advik Sirimarapu, Wilma K. Olson, Darrin M. York, Yuwei Gu   +10 more
wiley   +2 more sources