Results 41 to 50 of about 1,957,788 (244)

Knowledge and attitudes on contraceptives among undergraduates in the state universities of the Western Province

Journal of the College of Community Physicians, 2019
Objective: To describe knowledge and attitudes on contraceptives among undergraduates in the state universities of the Western Province Methods: A descriptive cross sectional study was conducted among 1575 second and third year undergraduates using ...
Upuli Perera, chrishantha Abeysena
doaj   +1 more source

Examining the place of the female condom in India’s family planning program: A qualitative investigation of the attitudes and opinions of key stakeholders in Pune, India

BMC Public Health, 2022
Background With overpopulation contributing to the depletion of planetary resources, the high rates of unintended pregnancies in India are a cause for concern.
Medhavi Weerasinghe, Shubhangi Agawane, Neelima Karandikar, Jane Fisher, Jayagowri Sastry   +4 more
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Screening HIV-positive men who have sex with men for hepatitis C re-infection risk: is a single question on condom-use enough? A sensitivity analysis

BMC Infectious Diseases, 2019
Background Hepatitis C virus (HCV) is common in men who have sex with men (MSM) with HIV. The Swiss HCVree Trial targeted a micro-elimination by using a treat and counsel strategy.
Patrizia Künzler-Heule, Sandra Engberg, Manuel Battegay, Axel J. Schmidt, Katharina Fierz, Huyen Nguyen, Agnes Kocher, Christiana Nöstlinger, Benjamin Hampel, Marcel Stöckle, Charles Béguelin, Julie Delaloye, Patrick Schmid, Markus Flepp, Mathieu Rougement, Dominique Laurent Braun, Jan Fehr, Dunja Nicca, the Swiss HIV Cohort Study (SHCS)   +18 more
doaj   +1 more source

The levels and factors associated with inconsistent condom use among young males with older, same-sex partners in South Africa

Cogent Social Sciences, 2020
Condom use among females with older, male sexual partners is well documented in South Africa. To a far lesser extent, condom use among males with older same-sex partners is known.
Nicole De Wet-Billings, Brendon K. Billings   +1 more
doaj   +1 more source

The effects of partner type on condom choice and condom use [PDF]

, 2010
Includes bibliographical references (p. 75-90).South Africa has one of the world's highest rates of HIV infection. Little previous research has focused on the relationship between individuals in different sexual contexts and their attitudes toward condom
Zondo, S
core   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source