Results 51 to 60 of about 1,957,788 (244)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Sexual behaviour and condom use among university students in Madagascar

SAHARA-J, 2008
Although the number of known HIV-infected students in Madagascar increased significantly between 1989 and 1995, very little is known about student behaviour with regard to AIDS.
Onja Holisoa Rahamefy, Michèle Rivard, Madeleine Ravaoarinoro, Lala Ranaivoharisoa, Andriamiliharison Jean Rasamindrakotroka, Richard Morisset   +5 more
doaj   +1 more source

Abstract Representation of Movement Parameters in Basal Ganglia Output

Advanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero, Diana I. Ortega‐Romero, Claudia I. Pérez‐Díaz, Pavel E. Rueda‐Orozco   +3 more
wiley   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

The importance of male partner involvement for women's acceptability and adherence to female-initiated HIV prevention methods in Zimbabwe. [PDF]

, 2010
Enlisting male partner involvement is perceived as an important component of women's successful uptake of female-initiated HIV prevention methods. We conducted a longitudinal study among a cohort of 955 Zimbabwean women participating in a clinical trial ...
van der Straten, Ariane, Agnes Chidanyika, Montgomery, Elizabeth T, Elizabeth T. Montgomery, Chidanyika, Agnes, Padian, Nancy, Jaffar, Shabbar, Ariane van der Straten, Chipato, Tsungai, Tsungai Chipato, Shabbar Jaffar, Nancy Padian   +11 more
core   +1 more source

An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management

Advanced Science, EarlyView.
Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer, Noël Strasser, Ilakkiya Ravindrarajah, Elsa Wrenger, Kristian Ivkovic, Jan Ševčík, Sima Šarčević, Lenka Červenková, Jáchym Rosendorf, Václav Liška, Alexandre H. Anthis, Thomas Rduch, Inge K. Herrmann   +12 more
wiley   +1 more source

Universal Access to Female Condoms (UAFC)

, 2014
First published by Oxfam Novib in March 2014, this case study focuses on the advocacy component of the Universal Access to Female Condoms (UAFC) programme, which is aimed at increasing choice and financial and political support for female condoms among ...
Demenint, Monique
core   +1 more source

Factors associated with consistent condom use: a cross-sectional survey of two Nigerian universities

BMC Public Health, 2019
Background Consistent condom use is central to the prevention of transmission of human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs), especially among young adults.
Anthony Idowu Ajayi, Kafayat Olanike Ismail, Wilson Akpan   +2 more
doaj   +1 more source

Relationship between exposure to the Avahan intervention and levels of reported condom use among men who have sex with men in southern India. [PDF]

, 2014
BACKGROUND: The Avahan intervention promotes consistent (100%) condom use amongst men who have sex with men in southern India. We assessed how condom use varies with intervention exposure for men who have sex with men in Bangalore. METHODS: Self-reported
Lowndes, Catherine M., Vickerman, P, Ramesh, Banadakoppa M., Deering, KN, Lowndes, CM, Kathleen N Deering, Foss, Anna M, Blanchard, James F, Prudden, Holly J., Boily, M-C, Washington, Reynold, James F Blanchard, Ramesh, BM, Prudden, Holly J, Marie-Claude Boily, Reynold Washington, Boily, Marie-Claude, Banadakoppa M Ramesh, Stephen Moses, Isac, S, Isac, Shajy, Holly J Prudden, Ramesh, Banadakoppa M, Prudden, HJ, Mitchell, KM, Foss, AM, Lowndes, Catherine M, Mitchell, Kate M., Foss, Anna M., Boily, Marie Claude, Vickerman, Peter, Deering, Kathleen N., Michel Alary, Alary, M, Catherine M Lowndes, Moses, S, Washington, R, Shajy Isac, Kate M Mitchell, Deering, Kathleen N, Anna M Foss, Peter Vickerman, Alary, Michel, Moses, Stephen, Blanchard, JF, Blanchard, James F., Mitchell, Kate M   +46 more
core   +2 more sources