Results 181 to 190 of about 5,629,528 (323)

Machine‐Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles

Advanced Science, EarlyView.
Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang, Ji Chen, Jinfeng Han, Wei Cheng, Jiang Qiu, Jianfeng Feng, Simon Eickhoff, Deniz Vatansever   +7 more
wiley   +1 more source

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

Exploration of Nakivale Refugees' and Stakeholders' Perceptions and Priorities of Male Engagement in Pregnancy, Childbirth, Postpartum, and Family Planning: A Qualitative Study. [PDF]

J Pregnancy
Lee H, Asiimire D, Atwiine J, Namanya B, Nsengiyumva R, Darbes L, Mwesigwa FS.   +6 more
europepmc   +1 more source

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Effect of combining lower- and higher-value monthly cash transfers with nutrition-sensitive agriculture, male engagement and psychosocial intervention on maternal depressive symptoms in rural Malawi: a secondary analysis of a cluster-randomised controlled trial. [PDF]

BMJ Glob Health
Bliznashka L, Nwabuikwu O, Ahun MN, Roschnik N, Phiri B, Gondwe-Matekesa E, Kachinjika M, Mvula P, Munthali A, Maggio D, Katundu M, Maleta K, Gladstone M, Gelli A, and the MAZIKO trial team.   +14 more
europepmc   +1 more source

A Dilemma in Male Engagement in Preventive Services: Adolescent Males' Knowledge and Attitudes Toward Testicular Cancer and Testicular Self-Exam

American Journal of Men's Health, 2009
P. Cronholm, J. Mao, Giang T Nguyen, R. T. Paris   +3 more
semanticscholar   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Mindfulness for people with long-term conditions and their family caregivers: a systematic review [PDF]

, 2019
Atteih, Badr, Barnett, Bauer, Beck, Ben Parkinson, Birnie, Bishop, Bohlmeijer, Camak, Carison, Carmody, Cash, Centre for Reviews and Dissemination, Clark, Cohen, De Ridder, Deek, Dixon-Woods, Dobkin, Evelyn McElhinney, Family Caregiver Alliance, Friis, Gambrel, Gotink, Greenwood, Hankin, Hou, Jaffray, Jo Booth, Kabat-Zinn, Kabat-Zinn, Kastner, Katon, Kershaw, King, Kroenke, Lawrence, Lengacher, Li, Maggie Lawrence, Marconi, Martire, Martire, Massimi, McNair, Meyer, Moher, Pace, Paller, Parkinson, Parsons, Radloff, Rajan, Regan, Ricci-Cabello, Rusbult, Schellekens, Smith, Snaith, Spanier, Spielberger, Spitzer, Teasdale, Traa, van den Hurk, Whitebird, Williamson, Wolff, Wood, World Health Organization, Yesavage   +71 more
core   +1 more source