Results 191 to 200 of about 3,525,982 (384)

Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility [PDF]

, 2021
Chunyu Liu, Chaofeng Tu, Lingbo Wang, Huan Wu, Brendan J. Houston, Francesco Mastrorosa, Wen Zhang, Ying Shen, Jiaxiong Wang, Shixiong Tian, Lanlan Meng, Jiangshan Cong, Shenmin Yang, Yiwen Jiang, Shuyan Tang, Yuyan Zeng, Mingrong Lv, Ge Lin, Jinsong Li, Hexige Saiyin, Xiaojin He, Jin Li, Aminata Touré, Pierre F. Ray, Joris A. Veltman, Qinghua Shi, Moira K. O’Bryan, Yunxia Cao, Yue‐Qiu Tan, Feng Zhang   +29 more
openalex   +1 more source

Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster

Advanced Science, EarlyView.
This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang, Ziling Yang, Yulu Pang, Xinyue Wu, Xinrong Zhang, Tao Zhu, Xiaoyue Ding, Wei Liu, Yuan Zhou, Pengcheng Zhang, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Gonadotropin and Testosterone hormone’s serum levels and partial deletions in the AZFc region in Iranian oligozoospermia infertile males

, 2011
Nasser Salsabili, Reza Mirfakhraei, Maryam Montazeri, Mitra Ataei, P Yaghmaei, Gholamreza Pourmand   +5 more
openalex   +2 more sources

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Lack of trusted diagnostic tools for undetermined male infertility

Journal of Assisted Reproduction and Genetics, 2021
Swati Pandruvada, Rachel Royfman, Tariq A. Shah, Puneet Sindhwani, J. Dupree, S. Schon, T. Avidor-Reiss   +6 more
semanticscholar   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Male infertility - Current concepts

Indian Journal of Urology, 2011
Rajeev Kumar
doaj   +1 more source

Basic and clinical genetic studies on male infertility in Iran during 2000-2016: A review

International Journal of Reproductive BioMedicine, 2018
The male factor contributes to 50% of infertility. The cause of male infertility is idiopathic and could be congenital or acquired. Among different factors which are involved in idiopathic male infertility, genetic factors are the most prevalent causes ...
Sahar Moghbelinejad, Hossein Mozdarani, Pegah Ghoraeian, Reihaneh Asadi   +3 more
doaj  

‘They are called Imperfect men’: Male Infertility and Sexual Health in Early Modern England [PDF]

, 2014
Jennifer Evans
openalex   +1 more source