Results 241 to 250 of about 181,476 (362)

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells

open access: yesAdvanced Science, EarlyView.
LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang   +5 more
wiley   +1 more source

The role of p53 in male infertility. [PDF]

open access: yesFront Endocrinol (Lausanne)
Li J   +7 more
europepmc   +1 more source

OcuPair, a Novel Photo‐crosslinkable PAMAM Dendrimer‐Hyaluronic Acid Hydrogel Bandage/Bioadhesive for Corneal Injuries and Temporary Corneal Repair

open access: yesAdvanced Science, EarlyView.
A schematic diagram showing the OcuPair adhesive hydrogel formulation loaded into the final delivery device and applied over the full‐thickness corneal wound in an in vivo rabbit model of corneal injury followed by in situ crosslinking to form a transparent hydrogel bandage sealing the wound.
Siva P. Kambhampati   +6 more
wiley   +1 more source

Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
This study has unveiled significant new insights into the role of MS4A4A in Alzheimer's disease‐related epilepsy, highlighting its impact on microglial phagocytosis, mitochondrial metabolism, and cytoskeleton, and demonstrating its therapeutic potential in epilepsy management.
Meng Jiang   +10 more
wiley   +1 more source

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