Results 281 to 290 of about 3,525,982 (384)

The Genetics of Female and Male Infertility. [PDF]

Dtsch Arztebl Int
Tüttelmann F, Wyrwoll MJ, Steingröver J, Wieacker P.   +3 more
europepmc   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, EarlyView.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Integrated profiling of semen microbiota and metabolome reveals dysregulation in primary idiopathic male infertility. [PDF]

J Transl Med
Yao H, Luo C, Xian Y, Liu B, Yang T, Tian R, Xiao X, Zhao W, Ying L, Xu J, Liu S, Jia Y, Luo X, Qiu D, Liu Y, Wu Q, Luo X, Liu Z, Li F.   +18 more
europepmc   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Correction: Cracking the code: how piRNA pathway shapes spermatogenesis and combats male infertility. [PDF]

Front Cell Dev Biol
Hong Z, Huang S, Li L, Gao Y, Ma B, Fan Q, Zhang Y, Wang M.   +7 more
europepmc   +1 more source

MCV/Q, Medical College of Virginia Quarterly, Vol. 14 No. 2 [PDF]

, 1978

core   +1 more source

Puerarin Targets MIC19 to Suppress Mitochondrial Metabolism of Tumor‐Infiltrating Tregs and Enhance Anti‐tumor Immunity

Advanced Science, EarlyView.
Puerarin targets mitochondrial MIC19 in tumor‐infiltrating Tregs, impairing their immunosuppressive function and enhancing antitumor immunity. This study uncovers the metabolic dependency of tumor‐infiltrating Tregs and highlights a potential metabolic‐targeted immunotherapeutic strategy for liver cancer. Abstract Regulatory T cells (Tregs) are pivotal
Yu Li, Ziyan Song, Jianjun Ding, Yiheng Zhou, Tianning Huang, Qufei Qian, Miao Yu, Wenzhao Chen, Jiazheng Liu, Ling Lu, Qiuyang Chen   +10 more
wiley   +1 more source

Male Infertility Management: A Critical Appraisal of Clinical Practice Guidelines With the AGREE II Instrument. [PDF]

Am J Mens Health
Li J, Li K, Zhang M, Chen J, Chen M, Dong W, Yu W, Lei L, Huang Y, Yang H, Ren P, Zou Q, Deng L.   +12 more
europepmc   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Understanding the impact of streptozotocin on diabetic male infertility: perspectives from rodent models and pharmacological networking. [PDF]

BMC Pharmacol Toxicol
Asghar MA, Li L, Wu J, Zhang G, Xiao R, Tang S, Wan B, Zhang X, Zhao Q.   +8 more
europepmc   +1 more source