Results 321 to 330 of about 3,525,982 (384)

OPTRACE: Optical Imaging–Guided Transplantation and Tracking of Cells in the Mouse Brain

open access: yesAdvanced Science, EarlyView.
OPTRACE establishes an optical, two‐step platform for intracerebral cell therapy. Transparent glass pipettes enable real‐time, image‐guided delivery, while multiplex genetic labeling with two‐photon and bioluminescence readouts supports longitudinal single‐cell tracking and host–graft dynamics.
Jinghui Wang   +10 more
wiley   +1 more source

Synovial Fluid‐derived Micrococcus Luteus G18 Exacerbates Osteoarthritis Progression by Promoting Chondrocyte Degradation via TLR2/JNK/AP‐1 Signaling Pathway

open access: yesAdvanced Science, EarlyView.
Traditionally considered sterile, the articular cavity is now recognized to harbor microbial communities influencing osteoarthritis (OA). Integrating 16S rRNA sequencing and culturomics, Micrococcus luteus is enriched in advanced OA. Notably, M. luteus G18 exacerbates cartilage degeneration via TLR2/JNK/AP‐1‐mediated ECM disruption, revealing intra ...
Tingtao Chen   +6 more
wiley   +1 more source

ATM rs189037 polymorphism: A potential genetic risk factor for sperm DNA damage and male infertility

open access: diamond
Gülbahar Güzel Erdal   +4 more
openalex   +1 more source

Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early‐Onset Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
This study identifies a unique physical signature of colorectal cancer in younger adults: their tissues are mechanically stiffer than those in older patients with the same cancer. Furthermore, stromal remodeling in early‐onset colorectal cancer promotes epithelial mechanotransduction and proliferation, showing how mechanical alterations in the tissue ...
Nicole C. Huning   +18 more
wiley   +1 more source

Functional and clinical insights into nuclear receptor variants for advancing precision diagnostics in male infertility. [PDF]

open access: yesEBioMedicine
Gaikwad AS   +12 more
europepmc   +1 more source

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

open access: yesAdvanced Science, EarlyView.
This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li   +7 more
wiley   +1 more source

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