Results 271 to 280 of about 3,211,357 (351)
Yourong Fan+13 more
semanticscholar +1 more source
An Off‐the‐Shelf Artificial Proregenerative Macrophage for Pressure Ulcer Treatment
Artificial macrophages (artM) by encapsulating M2 lysates into biodegradable PLGA microspheres and coated with macrophage membrane, are engineered as new therapeutics against skin pressure ulcer. In mouse models, the artM exhibited robust tissue repair through cell recruitment and microenvironment modulation, showing great therapeutic potential for ...
Qi Su+12 more
wiley +1 more source
Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie+10 more
wiley +1 more source
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun+10 more
wiley +1 more source
This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao+7 more
wiley +1 more source
The Hypoxia‐Associated High‐Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma
This study suggests the potential roles of a novel hypoxia‐associated CDC20+KIF20A+PTTG1+ cell subpopulation in glioma progression. This high‐risk glioma cell subpopulation is therapeutically vulnerable to glioma progression and may play important roles in glioma standard‐of‐care therapeutic resistance.
Quan Wan+13 more
wiley +1 more source