Results 1 to 10 of about 21,763 (256)

m6A-mRNA Methylation Regulates Gene Expression and Programmable m6A Modification of Cellular RNAs With CRISPR-Cas13b in Renal Cell Carcinoma

Frontiers in Genetics, 2022
Background: N6-methyladenosine (m6A) is the most extensive messenger RNA modification. Despite recent advances in the biological roles of m6A, its role in the development and progression of renal cell carcinoma (RCC) remains unclear.Methods: In this ...
Ying Gan, Ying Gan, Aolin Li, Aolin Li, Jun Liu, Jun Liu, Xiaofei Wang, Xiaofei Wang, Zhenan Zhang, Zhenan Zhang, Qinhan Li, Qinhan Li, Xiongjun Ye, Xiongjun Ye, Lin Yao, Lin Yao, Qian Zhang, Qian Zhang   +17 more
doaj   +1 more source

Single-Cell RNA Sequencing of Human Corpus Cavernosum Reveals Cellular Heterogeneity Landscapes in Erectile Dysfunction

Frontiers in Endocrinology, 2022
PurposeTo assess the diverse cell populations of human corpus cavernosum in patients with severe erectile dysfunction (ED) at the single-cell level.MethodsPenile tissues collected from three patients were subjected to single-cell RNA sequencing using the
Dong Fang, Dong Fang, Dong Fang, Xiao-Hui Tan, Xiao-Hui Tan, Xiao-Hui Tan, Wen-Peng Song, Wen-Peng Song, Wen-Peng Song, Yang-Yang Gu, Yang-Yang Gu, Yang-Yang Gu, Jian-Cheng Pan, Jian-Cheng Pan, Xiao-Qing Yang, Xiao-Qing Yang, Wei-Dong Song, Wei-Dong Song, Wei-Dong Song, Yi-Ming Yuan, Yi-Ming Yuan, Yi-Ming Yuan, Jing Peng, Jing Peng, Jing Peng, Zhi-Chao Zhang, Zhi-Chao Zhang, Zhi-Chao Zhang, Zhong-Cheng Xin, Zhong-Cheng Xin, Xue-Song Li, Xue-Song Li, Xue-Song Li, Rui-Li Guan, Rui-Li Guan, Rui-Li Guan   +35 more
doaj   +1 more source

Skimmed Bovine Milk-Derived Extracellular Vesicles Isolated via “Salting-Out”: Characterizations and Potential Functions as Nanocarriers

Frontiers in Nutrition, 2021
Bovine milk-derived extracellular vesicles (BM-EVs) are recognized as promising nanoscale delivery vectors owing to their large availability. However, few isolation methods can achieve high purity and yield simultaneously. Therefore, we developed a novel
Xiao-Hui Tan, Xiao-Hui Tan, Xiao-Hui Tan, Dong Fang, Dong Fang, Dong Fang, Yong-De Xu, Tie-Gui Nan, Wen-Peng Song, Wen-Peng Song, Wen-Peng Song, Yang-Yang Gu, Yang-Yang Gu, Yang-Yang Gu, Sheng-Ji Gu, Sheng-Ji Gu, Sheng-Ji Gu, Yi-Ming Yuan, Yi-Ming Yuan, Yi-Ming Yuan, Zhong-Cheng Xin, Zhong-Cheng Xin, Zhong-Cheng Xin, Li-Qun Zhou, Li-Qun Zhou, Li-Qun Zhou, Rui-Li Guan, Rui-Li Guan, Rui-Li Guan, Xue-Song Li, Xue-Song Li, Xue-Song Li   +31 more
doaj   +1 more source

Incidence of lower urogenital tract diseases in male dogs

International Journal of Veterinary Sciences and Animal Husbandry
Prasanth KM, Bharathi S, Kumar RVS, Santhilakshmi M, Raghunath M   +4 more
exaly   +2 more sources

TRAF2 promotes M2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear cell renal cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2023
Background The management of advanced clear cell renal cell carcinoma (ccRCC) remains a major challenge in clinical practice, and the construction of more reliable prognostic prediction models and the further elucidation of key molecular mechanisms of ...
Yawei Xu, Lei Li, Wuping Yang, Kenan Zhang, Zedan Zhang, Chaojian Yu, Jianhui Qiu, Lin Cai, Yanqing Gong, Zheng Zhang, Jingcheng Zhou, Kan Gong   +11 more
doaj   +1 more source

Silencing of the TRIM58 Gene by Aberrant Promoter Methylation is Associated with a Poor Patient Outcome and Promotes Cell Proliferation and Migration in Clear Cell Renal Cell Carcinoma

Frontiers in Molecular Biosciences, 2021
To investigate the underlying molecular mechanism of tripartite motif-containing 58 (TRIM58) in the development of clear cell renal cell carcinoma (ccRCC), we explored TRIM58 expression and methylation in tumor tissues and the association with ...
Ying Gan, Ying Gan, Ying Gan, Congcong Cao, Aolin Li, Aolin Li, Aolin Li, Haifeng Song, Haifeng Song, Haifeng Song, Guanyu Kuang, Guanyu Kuang, Guanyu Kuang, Binglei Ma, Binglei Ma, Binglei Ma, Quan Zhang, Quan Zhang, Quan Zhang, Qian Zhang, Qian Zhang, Qian Zhang   +21 more
doaj   +1 more source

Cancer immunotherapies: advances and bottlenecks

Frontiers in Immunology, 2023
Immunotherapy has ushered in a new era in cancer treatment, and cancer immunotherapy continues to be rejuvenated. The clinical goal of cancer immunotherapy is to prime host immune system to provide passive or active immunity against malignant tumors ...
Rui Rui, Rui Rui, Rui Rui, Rui Rui, Liqun Zhou, Liqun Zhou, Liqun Zhou, Liqun Zhou, Shiming He, Shiming He, Shiming He, Shiming He   +11 more
doaj   +1 more source

Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications

Frontiers in Immunology, 2023
Renal cell carcinoma (RCC) is one of the most malignant urological tumors. Currently, there is a lack of molecular markers for early diagnosis of RCC.
Rui Rui, Rui Rui, Rui Rui, Rui Rui, Liqun Zhou, Liqun Zhou, Liqun Zhou, Liqun Zhou, Shiming He, Shiming He, Shiming He, Shiming He   +11 more
doaj   +1 more source

Transcriptome-Wide Map of N6-Methyladenosine Methylome Profiling in Human Bladder Cancer

Frontiers in Oncology, 2021
N6-Methyladenosine (m6A) is the most widespread internal RNA modification in several species. In spite of latest advances in researching the biological roles of m6A, its function in the development and progression of bladder cancer remains unclear.
Aolin Li, Aolin Li, Aolin Li, Aolin Li, Ying Gan, Ying Gan, Ying Gan, Ying Gan, Congcong Cao, Binglei Ma, Binglei Ma, Binglei Ma, Binglei Ma, Quan Zhang, Quan Zhang, Quan Zhang, Quan Zhang, Qian Zhang, Qian Zhang, Qian Zhang, Qian Zhang, Lin Yao, Lin Yao, Lin Yao, Lin Yao   +24 more
doaj   +1 more source

Monitoring of Enterobacteria strains with producing β-lactamases in males with infectious-inflammatory diseases of urogenital tract

Medicni perspektivi, 2022
This article presents the findings of investigation of the microflora of 257 males with infectious-inflammatory diseases of the urogenital tract using the test system “Androflor”. The role of representatives of conditionally pathogenic microflora as the main etiological agent in occurrence of infectious-inflammatory diseases of the urogenital tract in ...
Sklyar T.V., Lavrentievа K.V., Kurahina N.V., Lykholat T.Yu., Papiashvili M.G., Lykholat O.A., Stepanskyi D.O.   +6 more
openaire   +3 more sources