Results 41 to 50 of about 1,518 (213)

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos   +4 more
wiley   +1 more source

Use of maleic hydrazide (MH) to induce branches in maiden fruit trees

open access: yesActa Agrobotanica, 2015
MH as a single spray in concentrations 700 -1500 mg/l was used in July to induce premature offshoots in nursery trees. The trees of pear, plum and of 3 apple cultivars showed little or no response to MH treatment Due to this treatment, however, the trees
L. S. Jankiewicz, J. Kozyra
doaj   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

open access: yesJournal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá   +4 more
wiley   +1 more source

Theoretical Investigation of Solvation Effects on the Tautomerism of Maleic Hydrazide

open access: yesE-Journal of Chemistry, 2012
A DFT study is used to calculate structural data of tautomers of maleic hydrazide (MH) in the gas phase and selected solvents such as benzene (non-polar solvent), tetrahydrofuran (polar aprotic solvent) and methanol (protic solvent), dimethyl sulfoxide ...
Meisam Shabanian   +3 more
doaj   +1 more source

Migration Groups: A Poorly Explored Point of View for Genetic Damage Assessment Using Comet Assay in Human Lymphocytes

open access: yesApplied Sciences, 2021
A new point of view for genetic damage assessment using the comet assay is proposed based on the number of migration groups, the number of comets in each group, and the groups with the highest number of comets. Human lymphocytes were exposed to different
Mónica Reynoso-Silva   +6 more
doaj   +1 more source

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli   +8 more
wiley   +1 more source

RELATIONSHIPS BETWEEN STRUCTURE AND ACTIVITY OF MALEIC HYDRAZIDE ANALOGUES AND RELATED COMPOUNDS

open access: yes, 1962
The growth inhibiting activities of a number of compounds structurally related to maleic hydrazide have been examined using the technique of bud growth inhibition.
H. V. Morley, I. Hoffman, E. V. Parups
core   +1 more source

Dual‐Layer Living Hydrogel Enables On‐Demand Delivery of Phages and Probiotics for Synergistic Wound Infection Therapy

open access: yesAdvanced Functional Materials, Volume 36, Issue 38, 11 May 2026.
A dual‐layer living hydrogel, ProΦGel, integrates bacteriophages and probiotics for synergistic wound infection therapy. The outer gelatin‐based matrix releases phages on demand in response to P. aeruginosa infections, while inner alginate beads sustain probiotic delivery.
Siyuan Tao   +6 more
wiley   +1 more source

Intensity of synthesis of the nucleic acids in the cytoplasmic organelles of plants in heterosis and stimulation of the growth processes by the influence of maleic hydrazide

open access: yesФактори експериментальної еволюції організмів, 2013
Aims. The study of changes in the content of nucleic acids in the mitochondria and chloroplasts of heterotic plants and stimulation of growth processes by the influence of maleic hydrazide. Methods.
A. D. Mamedova
doaj  

Turmeric and curcumin: From traditional medicine to modern therapeutic applications

open access: yesJSFA reports, Volume 6, Issue 5, Page 160-178, May 2026.
Abstract Turmeric (Curcuma longa), a medicinal plant, has maintained its cultural and therapeutic significance over centuries in Ayurveda, Unani, and Traditional Chinese Medicine. However, novel formulations and delivery methods are being developed to address these challenges.
Azma Nadeem   +7 more
wiley   +1 more source

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