Results 31 to 40 of about 3,845,917 (311)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

The influence of late-stage pupal irradiation and increased irradiated:un-irradiated male ratio on mating competitiveness of the malaria mosquito Anopheles arabiensis Patton [PDF]

, 2009
Competitiveness of released males in genetic control programmes is of critical importance. In this paper, we explored two scenarios to compensate for the loss of mating competitiveness after pupal stage irradiation in males of the malaria mosquito ...
Helinski, M., Knols, B.G.J.
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Rétrograde venous perfusion (RVP) for intraçtable venous leg ulcers: a retrospective analysis

European Journal of Medical Research
Background Retrograde venous perfusion (RVP) is a minimally invasive procedure in which the limb circulation is isolated by the application of a proximal limb tourniquet, followed by the administration of specific medications through a distal limb vein ...
Alaa Sharabi, Mohammed Abd-Eltawab, Sherif A. Sharabi, Mai A. Elkalla, Yossef N. Abdelbaky, Mohamed A. Abou Yossef, Ahmed Mousa   +6 more
doaj   +1 more source

Streptococcus agalactiae-associated Urinary Tract Infections amongst Male Patients at a Tertiary Care Setting in Southwest India

Journal of Medical Microbiology and Infectious Diseases, 2022
Introduction: The occurrence of urinary tract infections (UTIs) caused by the group B Streptococcus (GBS) in females is well documented. On the contrary, the prevalence amongst males is infrequent, and studies from the Indian subcontinent are limited.
Asem Ali Ashraf1, Sreejith Govindan2, Nagalakshmi Narasimhaswamy2, Akshita Gupta1   +3 more
doaj   +1 more source

Curricular noticing: A comprehensive framework to describe teachers’ interactions with curriculum materials [PDF]

, 2018
Building on the work of Professional Noticing of Children’s Mathematical Thinking, we introduce the Curricular Noticing Framework to describe how teachers recognize opportunities within curriculum materials, understand their affordances and limitations ...
Amador, Julie, Dietiker, Leslie, Earnest, Darrell, Males, Lorraine M.   +3 more
core  

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Spatial Distribution and Factors Associated With Risky Health Behavior Among Adult Males Aged 15–59 Years in Ethiopia: Generalized Structural Equation Modeling

Frontiers in Psychiatry, 2022
BackgroundAlcohol drinking and tobacco smoking are the largest preventable causes of death and important risk factors for a number of non-communicable diseases and cause premature death and many socioeconomic consequences. Therefore, the present study is
Sewnet Adem Kebede, Adisu Birhanu Weldesenbet, Biruk Shalmeno Tusa   +2 more
doaj   +1 more source

Phenotypic characteristics of the p.Asn215Ser (p.N215S) GLA mutation in male and female patients with Fabry disease: A multicenter Fabry Registry study. [PDF]

, 2018
BackgroundThe p.Asn215Ser or p.N215S GLA variant has been associated with late-onset cardiac variant of Fabry disease.MethodsTo expand on the scarce phenotype data, we analyzed natural history data from 125 p.N215S patients (66 females, 59 males ...
Brand, Eva, Burlina, Alessandro, Cecchi, Franco, Garman, Scott C, Germain, Dominique P, Jovanovic, Ana, Kempf, Judy, Laney, Dawn A, Linhart, Aleš, Maródi, László, Nicholls, Kathy, Ortiz, Alberto, Pieruzzi, Federico, Shankar, Suma P, Waldek, Stephen, Wanner, Christoph   +15 more
core   +1 more source