Results 1 to 10 of about 138,015 (269)

Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects

Cell Death and Disease, 2021
Impaired autophagy and excessive apoptosis disrupt cellular homeostasis and contribute to neural tube defects (NTDs), which are a group of fatal and disabling birth defects caused by the failure of neural tube closure during early embryonic development ...
Wanqi Huang, Tianchu Huang, Yusi Liu, Jialin Fu, Xiaowei Wei, Dan Liu, Wei Ma, Hui Gu, Zhengwei Yuan   +8 more
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PIWI-interacting RNA sequencing profiles in maternal plasma-derived exosomes reveal novel non-invasive prenatal biomarkers for the early diagnosis of nonsyndromic cleft lip and palate

EBioMedicine, 2021
Background: Congenital malformations are common birth defects with high neonatal morbidity and mortality. It is essential to find simpler and more efficient biomarkers for early prenatal diagnosis. Therefore, we investigated PIWI-interacting RNAs (piRNAs)
Shanshan Jia, Qiang Zhang, Yu Wang, Yanfu Wang, Dan Liu, Yiwen He, Xiaowei Wei, Hui Gu, Wei Ma, Wenting Luo, Zhengwei Yuan   +10 more
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Impact of prenatal exposure to metallic elements on neural tube defects: Insights from human investigations

Ecotoxicology and Environmental Safety, 2023
Metallic elements play a pivotal role in maternal and fetal health. Metals can cross the placental barrier and be absorbed by fetuses, where they may affect closure of the neural tube during embryonic development. Neural tube defects (NTDs), which result
Wanqi Huang, Jialin Fu, Zhengwei Yuan, Hui Gu   +3 more
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Intra-amniotic transplantation of brain-derived neurotrophic factor-modified mesenchymal stem cells treatment for rat fetuses with spina bifida aperta

Stem Cell Research & Therapy, 2022
Background Spina bifida aperta (SBA) is a relatively common clinical type of neural tube defect. Although prenatal fetal surgery has been proven to be an effective treatment for SBA, the recovery of neurological function remains unsatisfactory due to ...
Wei Ma, Xiaowei Wei, Hui Gu, Dan Liu, Wenting Luo, Songying Cao, Shanshan Jia, Yiwen He, Lizhu Chen, Yuzuo Bai, Zhengwei Yuan   +10 more
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Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseases

Frontiers in Cell and Developmental Biology, 2023
Cardiovascular diseases (CVDs) are the leading cause of mortality and disability worldwide. Numerous studies have demonstrated that non-coding RNAs (ncRNAs) play a primary role in CVD development.
Xue Sun, Xue Sun, Gebang Wang, Wenting Luo, Hui Gu, Wei Ma, Xiaowei Wei, Dan Liu, Shanshan Jia, Songying Cao, Yu Wang, Zhengwei Yuan   +11 more
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Exploring the prognostic differences in patients of Chiari malformation type I with syringomyelia undergoing different surgical methods

Frontiers in Neurology, 2023
BackgroundThe best surgical treatment of Chiari malformation patients with syringomyelia remains controversial, and whether cerebellar tonsillectomy should be performed has not been decided.ObjectiveTo evaluate the efficacy of posterior fossa ...
Mingchu Zhang, Mingchu Zhang, Yan Hu, Yan Hu, Dengpan Song, Dengpan Song, Chengcheng Duan, Chengcheng Duan, Mingkun Wei, Mingkun Wei, Longxiao Zhang, Longxiao Zhang, Shixiong Lei, Fuyou Guo, Fuyou Guo   +14 more
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Efficacy and safety of sclerosants in the treatment of venous malformations: A network meta-analysis of randomized controlled trials

Chinese Journal of Plastic and Reconstructive Surgery, 2022
Background: Venous malformations (VMs) are the most common low-flow vascular malformations. Although various sclerosants are effective, their relative effects have not yet been well established.
Wei Lu, Zhenyu Yang, Zuoliang Qi, Xiaonan Yang   +3 more
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Intra-Amniotic Delivery of CRMP4 siRNA Improves Mesenchymal Stem Cell Therapy in a Rat Spina Bifida Model

Molecular Therapy: Nucleic Acids, 2020
Neural tube defects (NTDs) result in prenatal mortality and lifelong morbidity, and available treatments have limited efficacy. We previously suggested that prenatal bone marrow-derived mesenchymal stem cell (BMSC) transplantation could treat neuron ...
Xiaowei Wei, Songying Cao, Wei Ma, Chaonan Zhang, Hui Gu, Dan Liu, Wenting Luo, Yuzuo Bai, Weilin Wang, Zhengwei Yuan   +9 more
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Tumor Necrosis Factor Alpha Signaling and Organogenesis

Frontiers in Cell and Developmental Biology, 2021
Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication.
Kai You, Hui Gu, Zhengwei Yuan, Xuewen Xu, Xuewen Xu   +4 more
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TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis

Clinical Epigenetics, 2019
Background Neural tube defects (NTDs) are complex abnormalities associated with gene-environment interactions. The underlying cause has not been determined. Methods Spinal cord tissues from cases with NTDs and healthy controls were collected. Methylation
Henan Zhang, Yi Guo, Hui Gu, Xiaowei Wei, Wei Ma, Dan Liu, Kun Yu, Wenting Luo, Ling Ma, Yusi Liu, Jia Xue, Jieting Huang, Yanfu Wang, Shanshan Jia, Naixuan Dong, Hongyan Wang, Zhengwei Yuan   +16 more
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