Results 1 to 10 of about 51,265 (114)

Trend and burden of neural tube defects among cohort of pregnant women in Ethiopia: Where are we in the prevention and what is the way forward?

PLoS ONE, 2022
Introduction Neural tube defect is one of the top five most serious birth defects in the world. In Ethiopia an accurate estimate of the trend and burden of neural tube defects is still unknown.
Anteneh Berhane, Tefera Belachew
doaj   +5 more sources

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Cell Reports, 2019
Summary: Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete penetrance. We found that the combined loss of pro-apoptotic BIM and p53
Alex R.D. Delbridge, Andrew J. Kueh, Francine Ke, Natasha M. Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E. May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J. Herold, Ygal Haupt, Gordon K. Smyth, Tim Thomas, Marnie E. Blewitt, Andreas Strasser, Anne K. Voss   +21 more
doaj   +3 more sources

Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis.

PLoS ONE, 2015
BackgroundIn the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant.
Komal Preet Allagh, B R Shamanna, Gudlavalleti V S Murthy, Andy R Ness, Pat Doyle, Sutapa B Neogi, Hira B Pant, Wellcome Trust- PHFI Folic Acid project team   +7 more
doaj   +3 more sources

Folic acid supplementation and neural tube defects: a cross-sectional study of knowledge and practice among pregnant mothers in Lira, Northern Uganda [PDF]

BMC Pregnancy and Childbirth
Background and aim Folic acid requirements increase during pregnancy to meet the metabolic needs, DNA synthesis, and rapid cell division during fetal development.
Rebecca Nakaziba, Miriam Muhindo
doaj   +2 more sources

Somitic mesoderm morphogenesis is necessary for neural tube closure during Xenopus development

Frontiers in Cell and Developmental Biology, 2023
Neural tube closure is a fundamental process during vertebrate embryogenesis, which leads to the formation of the central nervous system. Defective neural tube closure leads to neural tube defects which are some of the most common human birth defects ...
Neophytos Christodoulou, Paris A. Skourides   +1 more
doaj   +1 more source

A quest for genetic causes underlying signaling pathways associated with neural tube defects

Frontiers in Pediatrics, 2023
Neural tube defects (NTDs) are serious congenital deformities of the nervous system that occur owing to the failure of normal neural tube closures. Genetic and non-genetic factors contribute to the etiology of neural tube defects in humans, indicating ...
Sunil Rai, Larissa Leydier, Shivani Sharma, Jigar Katwala, Anurag Sahu   +4 more
doaj   +1 more source

Thoracic and lumbar multiple neural tube defects with post repair hydrocephalus: A case report and literature review

Interdisciplinary Neurosurgery, 2023
Background: Neural tube defects are among the most common congenital anomalies, particularly in developing countries owing to significant folic acid deficiency. Nevertheless, multiple-site open neural tube defects are extremely rare.
Eyerusalem Bergene, Merhawi Leake, Yibeltal Zewdu, Abdulaziz Abdellah   +3 more
doaj   +1 more source

Multiple site neural tube defects at Zewuditu Memorial Hospital, Addis Ababa, Ethiopia: a case report

Journal of Medical Case Reports, 2021
Background Neural tube defects are common group of central nervous system anomalies of complex etiology and major public health importance worldwide. The occurrence of multiple neural tube defects, however, is an extremely rare event and has never been ...
Mestet Yibeltal Shiferaw, Atalel Fentahun Awedew, Tsegazeab Laeke T/Mariam, Abenezer Tirsit Aklilu, Yemisirach Bizuneh Akililu, Aemiro Mazengia Andualem   +5 more
doaj   +1 more source

Birth prevalence of neural tube defects and associated risk factors in Africa: a systematic review and meta-analysis

BMC Pediatrics, 2021
Background Neural tube defects are common congenital anomalies that result from early malformation in the development of the spinal cord and brain. It is related to substantial mortality, morbidity, disability, and psychological and economic costs.
Mohammed Oumer, Ashenafi Tazebew, Mezgebu Silamsaw   +2 more
doaj   +1 more source

Determinants of neural tube defect among children at zewditu memorial hospital, addis ababa, ethiopia a case control study

International Journal of Africa Nursing Sciences, 2021
Background: Neural tube defects are one of the most common malformations with a worldwide prevalence of 1–3 per1000 live births. They are the result of failure of the neural tube to close during the 21–28 embryonic days and it had multi-factorial ...
Filmawit Aynalem Tesfay, Fekadu Bulte Aga, Girum Sebsibie Teshome   +2 more
doaj   +1 more source