Results 101 to 110 of about 1,171,489 (373)
Thyroid, 2015 BACKGROUND Increased recognition of the indolent nature of noninvasive follicular variant of papillary thyroid carcinoma (NFVPTC) along with greater insight into the molecular alterations of these tumors has prompted endocrine pathologists to question ...
K. Strickland +6 more
semanticscholar +1 more source
Novel Method for Mutational Disease Prediction using Bioinformatics Techniques and Backpropagation Algorithm [PDF]
arXiv, 2013 Cancer is one of the most feared diseases in the world it has increased disturbingly and breast cancer occurs in one out of eight women, the prediction of malignancies plays essential roles not only in revealing human genome, but also in discovering effective prevention and treatment of cancers.
arxiv
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Endometriosis-associated Malignancy
Geburtshilfe und Frauenheilkunde, 2016 Endometriosis is a common condition in women of reproductive age. According to several epidemiological studies endometriosis may be associated with increased risk of various malignancies.
N. Krawczyk +4 more
semanticscholar +1 more source
Development of shellfish allergy after exposure to dual immune checkpoint blockade
Hepatic Oncology, 2018 Hepatocellular carcinoma (HCC) is a major health problem worldwide with limited systemic therapies available. Immunotherapy is a fast-moving field that is quickly evolving as a treatment for HCC with three recent clinical trials published treating HCC ...
Zachary J Brown +2 more
doaj +1 more source
Joint Learning for Pulmonary Nodule Segmentation, Attributes and Malignancy Prediction [PDF]
arXiv, 2018 Refer to the literature of lung nodule classification, many studies adopt Convolutional Neural Networks (CNN) to directly predict the malignancy of lung nodules with original thoracic Computed Tomography (CT) and nodule location. However, these studies cannot tell how the CNN works in terms of predicting the malignancy of the given nodule, e.g., it's ...
arxiv
Joint Stream: Malignant Region Learning for Breast Cancer Diagnosis [PDF]
Volume 99, January 2025, 106899Early diagnosis of breast cancer (BC) significantly contributes to reducing the mortality rate worldwide. The detection of different factors and biomarkers such as Estrogen receptor (ER), Progesterone receptor (PR), Human epidermal growth factor receptor 2 (HER2) gene, Histological grade (HG), Auxiliary lymph node (ALN) status, and Molecular subtype ...
arxiv +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source