Results 241 to 250 of about 1,657,236 (389)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Indication of elective colon resection for left-sided diverticulitis in the Asian population

Asian Journal of Surgery, 2020
Hyun Jung Park, Sangtae Choi, Jeong Heum Baek, Yeon Ho Park, Jin-mo Kang, Won-Suk Lee   +5 more
doaj   +1 more source

Integrated genomic analysis to reduce chromosomal analysis for the diagnosis of pediatric hematologic malignancies: addressing the shortage of cytogenetic technologists

Dong Li, Sarah K. Tasian, Gerald Wertheim, Susan R. Rheingold, Kathrin M. Bernt, Haley Newman, Luanne Wainwright, Donna Wilmoth, Brian Thiel, Lea F. Surrey, Elizabeth Margolskee, Vinodh Pillai, Minjie Luo, Michele Paessler, Stephen P. Hunger, Marilyn M. Li, Yiming Zhong   +16 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Microcalcification and Irregular Margins as Key Predictors of Thyroid Cancer: Integrated Analysis of EU-TIRADS, Bethesda, and Histopathology. [PDF]

Medicina (Kaunas)
Çimen Ş, Zeybek N, Bahçecioğlu AB, Yılmaz KB, Gülçelik NE, Gülçelik MA.   +5 more
europepmc   +1 more source

Association of IgG4‐Related Disease With History of Malignancy

Arthritis & Rheumatology, 2016
Z. Wallace, C. J. Wallace, N. Lu, Hyon K. Choi, J. Stone   +4 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Comparison of Cytological, Histopathological, and Imaging Findings Based on 10 mm Threshold in Pediatric Thyroid Nodules. [PDF]

Children (Basel)
Cin M, Özcan B.
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

A Rare Case of Necrotising Sarcoid Granulomatosis Presenting as Bilateral Pulmonary Masses Mimicking Malignancy. [PDF]

Respirol Case Rep
Chung J, O'Donnell R, Sabih A.
europepmc   +1 more source