Results 51 to 60 of about 1,171,489 (373)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Infliximab Is Not Associated With Increased Risk of Malignancy or Hemophagocytic Lymphohistiocytosis in Pediatric Patients With Inflammatory Bowel Disease.

Gastroenterology, 2017
BACKGROUND AND AIMS Immunosuppressive therapy for inflammatory bowel disease (IBD) in pediatric patients is thought to increase the risk of malignancy and lymphoproliferative disorders, including hemophagocytic lymphohistiocytosis (HLH).
J. Hyams, M. Dubinsky, R. Baldassano, R. Colletti, S. Cucchiara, J. Escher, W. Faubion, J. Fell, B. Gold, A. Griffiths, S. Koletzko, S. Kugathasan, J. Markowitz, F. Ruemmele, G. Veereman, H. Winter, N. Masel, C. R. Shin, K. Tang, M. Thayu   +19 more
semanticscholar   +1 more source

An Automatic System to Discriminate Malignant from Benign Massive Lesions on Mammograms [PDF]

Nuclear Instruments and Methods in Physics Research A 569 (2006) 596-600, 2007
Mammography is widely recognized as the most reliable technique for early detection of breast cancers. Automated or semi-automated computerized classification schemes can be very useful in assisting radiologists with a second opinion about the visual diagnosis of breast lesions, thus leading to a reduction in the number of unnecessary biopsies.
arxiv   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

A consensus review on malignancy‐associated hemophagocytic lymphohistiocytosis in adults

Cancer, 2017
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe immune activation and dysregulation resulting in extreme and often life‐threatening inflammation.
N. Daver, K. McClain, C. Allen, S. Parikh, Z. Otrock, C. Rojas-Hernandez, B. Blechacz, Sa A. Wang, M. Minkov, M. Jordan, P. La Rosée, H. Kantarjian   +11 more
semanticscholar   +1 more source

Effective management of a rare case of primary renal intravascular large B-cell lymphoma with modified R-CHOP regimen: A case report

SAGE Open Medical Case Reports
Intravascular large B-cell lymphoma, known for its diverse organ involvement, presents significant diagnostic challenges, particularly when it affects the kidneys. This report highlights a rare case of primary renal intravascular large B-cell lymphoma in
Xianbo Huang, Xianhui Wu, Shasha Wang, Chen Mei, Yu Xu, Yanling Ren, Jie Jin, Hongyan Tong, Jiejing Qian   +8 more
doaj   +1 more source

Malignancy Prediction and Lesion Identification from Clinical Dermatological Images [PDF]

arXiv, 2021
We consider machine-learning-based malignancy prediction and lesion identification from clinical dermatological images, which can be indistinctly acquired via smartphone or dermoscopy capture. Additionally, we do not assume that images contain single lesions, thus the framework supports both focal or wide-field images.
arxiv  

An Efficient Automatic Mass Classification Method In Digitized Mammograms Using Artificial Neural Network [PDF]

International Journal of Artificial Intelligence & Applications 1.3 (2010) 1-13, 2010
In this paper we present an efficient computer aided mass classification method in digitized mammograms using Artificial Neural Network (ANN), which performs benign-malignant classification on region of interest (ROI) that contains mass. One of the major mammographic characteristics for mass classification is texture. ANN exploits this important factor
arxiv   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Efficacy and Safety of Edoxaban in Patients With Active Malignancy and Atrial Fibrillation: Analysis of the ENGAGE AF‐TIMI 48 Trial

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2018
Background Anticoagulation in patients with malignancy and atrial fibrillation is challenging because of enhanced risks for thrombosis and bleeding and the frequent need for invasive procedures. Data on direct oral antagonists in such patients are sparse.
Christina L. Fanola, C. Ruff, S. Murphy, James Jin, A. Duggal, Noe A. Babilonia, P. Sritara, M. Mercuri, P. Kamphuisen, E. Antman, E. Braunwald, R. Giugliano   +11 more
semanticscholar   +1 more source