Results 171 to 180 of about 3,136,872 (312)

Single-cell transcriptomic analysis reveals fatty acid metabolic heterogeneity and identifies DKK1 as a candidate prognostic factor in osteosarcoma. [PDF]

Front Endocrinol (Lausanne)
Wang L, Gao M, Liang Z.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

B‐cell maturation antigen expression and clinical features of plasmablastic lymphoma

eJHaem
Ning Dong, Hailing Zhang, Jinming Song, Jamila Mammadova, Bijal Shah, Hayder Saeed, Sameh Gaballa, Ariel Grajales‐Cruz, Leidy Isenalumhe, Celeste Bello, Lubomir Sokol, Javier Pinilla, Julio Chavez   +12 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Asciminib in late-line CML treatment

Blood Advances
Kendra Sweet, Javier Pinilla-Ibarz
doaj   +1 more source

Identification of novel paracrine therapeutic targets in peritoneal metastases through integrative proteotranscriptomic analysis of ascites. [PDF]

Mol Cancer
Liu Y, Chong CYL, Wang Y, Xu L, Lim HJ, Tan QX, Hendrikson J, Tan JW, Ng G, Guo W, Wang Y, Huang L, Ge W, Rethineswaran VK, Ong JZL, Quek YE, Ang AJY, Teo F, Chen OW, Rajesh A, Zhang Y, Ko TK, Kannan B, Lim BY, Lee ECY, Guo Z, Lakshmanan V, Shannon NB, Jegannathan N, Joseph CR, Neo ZW, Chong LY, Ng ARH, Lee JJ, Loo LH, Wu Y, Zhang S, Nie L, Zhang Q, Zeng L, Lim TKH, Ng MCH, Lee CJZ, Chang PEJ, Kim-Jun Teh K, Tan HK, Nadarajah R, Yong TT, Wang J, Aggarwal IM, Fong ELS, Wu KZ, So JBY, Yeoh KG, Wong JSM, Seo CJ, Cai M, Chia CS, Teh BT, Tan IB, Yeong J, Chan JY, Guo T, Ong CJ, Singapore Peritoneal Oncology Study (SPOS) Group and Singapore Gastric Cancer Consortium (SGCC).   +64 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Complementary Breath Profiling Using eNose and Gas Chromatography-Mass Spectrometry for Noninvasive Triage of Indeterminate Pulmonary Nodules. [PDF]

MedComm (2020)
Afridi WA, Hartel G, Zhang X, Pass D, Fielding D, Punyadeera C.   +5 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source