Results 201 to 210 of about 3,636,929 (290)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Peritoneal mesothelioma as an incidental finding during inguinal hernia surgery. [PDF]

J Surg Case Rep
Andresen JR, Monteiro EL, Liedke MO.
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Integration of single cell and bulk transcriptomic analyses identifies FAM189A2 as a key prognostic gene in lung cancer. [PDF]

Front Immunol
Guo P, Xiang M, Chen J, Zhang H.
europepmc   +1 more source

EP-1333: Re-recurrence pattern after re-irradiation with bevacizumab in recurrent malignant glioma

, 2015
Maximilian Niyazi, Natalie Jansen, M. Rottler, Ute Ganswindt, Claus Belka   +4 more
openalex   +1 more source

FRI0304 The utility of 18F FDG-PET/CT in distinguishing benign from malignant retroperitoneal fibrosis [PDF]

, 2017
Y Wang, Zhiwei Guan, Dongmei Gao, Jia Zhu, J Zhang, F Huang   +5 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Primary Malignant Melanoma of the Lung With a Long-Term Course: A Case Report. [PDF]

Respirol Case Rep
Fukushima Y, Azuma M, Miyagi Y, Kitamura M, Miyamoto K, Mizuki Y, Nakayama S, Ueda T.   +7 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Cervical Intranodal Schwannoma and Its Malignant Transformation: A Case Report With Literature Review. [PDF]

Clin Case Rep
Hussain S, Khan ZU, Liaqat N, Shah SW, Khan K, Ikram J.   +5 more
europepmc   +1 more source