Results 191 to 200 of about 478,842 (334)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Clinical and pathological characteristics and correlation analysis of anorectal malignant melanoma. [PDF]

Medicine (Baltimore)
Xi L, Zhou J, Wu Y, Zhai B, Rong R.
europepmc   +1 more source

Analysis of cancer-associated fibroblasts and the epithelial-mesenchymal transition in cutaneous basal cell carcinoma, squamous cell carcinoma, and malignant melanoma

, 2018
Kousuke Sasaki, Tamotsu Sugai, Kazuyuki Ishida, Mitsumasa Osakabe, Hiroo Amano, Hiroaki Kimura, Minoru Sakuraba, Katsuhiko Kashiwa, Seiichiro Kobayashi   +8 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Benign or aggressive? Understanding spinal melanocytomas in comparison to malignant melanoma. [PDF]

J Neurooncol
Ryba A, Mohme T, Kerschbaumer J, von Bronewski E, Hubertus V, Butenschoen VM, Kramer A, Stengel FC, Stienen MN, Battistelli M, Polli FM, Meyer HS, Dührsen L, Mende KC, Westphal M, Ringel F, Meyer B, Onken J, Thome C, Eicker SO, Mohme M.   +20 more
europepmc   +1 more source

Case Report: Malignant melanoma in a patient with Crohn’s disease treated with ustekinumab

, 2023
Georgios Axiaris, Alexandros Ioannou, Marina Papoutsaki, Leonidas Marinos, Michalis Liontos, Spyridon Michopoulos, Evanthia Zampeli   +6 more
openalex   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Anorectal malignant melanoma: curative abdominoperineal resection: patient selection with 18F-FDG-PET/CT [PDF]

, 2016
Claudius Falch, Sven Mueller, Andreas Kirschniak, Manuel Braun, Alfred Koenigsrainer, Bernhard Klumpp   +5 more
openalex   +1 more source

SLPI⁺ AT2‐Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche

Advanced Science, EarlyView.
Integrating spatial transcriptomics and single‐cell RNA sequencing, this study identifies a novel subpopulation of SLPI⁺ AT2‐like cells at the invasive margin of lung adenocarcinoma (LUAD). These cells, through stromal crosstalk and Wnt pathway activation, promote tumor stemness and invasion.
Zhoufeng Wang, Guonian Zhu, Pan Tang, Yan Wang, Wenxin Luo, Wenpeng Song, Zhikang Pan, Bingjie Zheng, YongChao Jiang, Defu Xiao, Xin Jin, Yong Bai, Guowei Che, Weimin Li   +13 more
wiley   +1 more source

Beyond the Skin: A Rare Case of Primary Malignant Melanoma of the Lung. [PDF]

Cureus
Baloch SS, Zarubin V, Wasio A, Khan Hadi D, Raza Khan S.   +4 more
europepmc   +1 more source