Results 201 to 210 of about 478,842 (334)

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Primary malignant melanoma of the bladder: A rare case report. [PDF]

Urol Case Rep
Díaz-Fuentes H, Fuziwara-Ruíz S, de Los Santos-Frias E, Amaya-Fragoso E, Rodríguez-Araujo E, Ramos-Arceo E, Aguirre-Amador L, Hernández-Rodríguez C.   +7 more
europepmc   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Trends in Survival and Cure Indicators of Thin and Thick Cutaneous Malignant Melanoma in Italy. [PDF]

Cancer Med
Mancini S, Toffolutti F, Zamagni F, Bucchi L, Crocetti E, Giudici F, Bella F, Benedetto A, Bidoli E, Carone S, Carrozzi G, Cascone G, Cavallo R, Cozzi I, Falcini F, Ferretti S, Iacovacci S, Mantovani W, Mian M, Michiara M, Rocino MT, Scuderi T, Ridolfi L, Stanganelli I, Guzzinati S, Dal Maso L, AIRTUM Working Group.   +26 more
europepmc   +1 more source

Primary malignant melanoma of the right sole: A case report

, 2022
Feng Ding, Peng Ye
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Malignant melanoma of the anal canal: a case report. [PDF]

J Surg Case Rep
Parajuli S, Sah S, Pandit N.
europepmc   +1 more source

A Case of Primary Malignant Melanoma of the Esophagus

, 2004
Takeo Nomi, Teruyuki SAKAGUCHI, Yukishige Yamada, Yoshiyuki Nakazima   +3 more
openalex   +2 more sources

PD-1 Inhibition in Malignant Melanoma and Lack of Clinical Response in Chronic Lymphocytic Leukemia in the Same Patients: A Case Series [PDF]

, 2020
Ivan Landego, Donna Hewitt, Irena Hibbert, Dhali H.S. Dhaliwal, W. Pieterse, Debjani Grenier, Ralph Wong, James B. Johnston, Versha Banerji   +8 more
openalex   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source