Results 41 to 50 of about 409,422 (240)

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Post-irradiation pericardial malignant mesothelioma with deletion of p16: a case report

Cancer Biology & Medicine, 2018
Malignant mesotheliomas are rather uncommon neoplasms associated primarily with asbestos exposure; however, they may also arise as second primary malignancies after radiation therapy, with a latency period of 15–25 years.
Yalda B. Naeini, Ramir Arcega, Sharon Hirschowitz, Nagesh Rao, Haodong Xu   +4 more
doaj   +1 more source

Malignant pericardial mesothelioma [PDF]

European Journal of Cardio-Thoracic Surgery, 2011
A 72-year-old female, who had no asbestos exposure, felt chest pain. She was diagnosed with pericarditis. After 6 months, a follow-up chest computed tomography (CT) showed a thickened pericardium (Fig. 1(A) and (B)) and a positron emission tomography (PET) scan was positive along the pericardium (Fig. 1(C)).
Motoki, Sakuraba, Takahiro, Tatsumori, Michihiro, Hirama, Kanako, Ogura   +3 more
openaire   +2 more sources

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Malignant pleural mesothelioma

Annals of Oncology, 2006
Malignant pleural mesothelioma G. L. Ceresoli, G. P. Betta, B. Castagneto, F. Facciolo, G. Arcangeli, P. A. Zucali, R. Libener, D. De Giovanni, E. Melis & M. A. Mirri Department of Medical Oncology and Hematology, Istituto Clinico Humanitas IRCCS, Rozzano (MI); Pathology Unit, Department of Oncology, Azienda Sanitaria Ospedaliera, Alessandria ...
G L, Ceresoli, G P, Betta, B, Castagneto, F, Facciolo, G, Arcangeli, P A, Zucali, R, Libener, D, De Giovanni, E, Melis, M A, Mirri   +9 more
openaire   +2 more sources

Next‐Generation CAR‐T Cell Therapy: From Modular Design to Clinical Expansion

Exploration, EarlyView.
Over the past decades, chimeric antigen receptor (CAR)‐T cell therapy has evolved from a linear engineering concept into a powerful yet constrained immunotherapy, limited by tumour microenvironment barriers, immune evasion, and manufacturing complexity.
Yuesong Bai, Jintao Qin, Zongjun Dai, Ran Yan, Yong Yang, Wenguang Wang   +5 more
wiley   +1 more source

The expected burden of mesothelioma mortality in Great Britain from 2002 to 2050 [PDF]

, 2005
The British mesothelioma register contains all deaths from 1968 to 2001 where mesothelioma was mentioned on the death certificate. These data were used to predict the future burden of mesothelioma mortality in Great Britain.
McElvenny, D, J T Hodgson, Peto, J, McElvenny, Damien, J Peto, Hodgson, John, Price, MJ, A J Darnton, Hodgson, JT, D M McElvenny, McElvenny, DM, Darnton, AJ, Price, Malcolm; id_orcid, M J Price   +13 more
core   +1 more source

Risk factors, prognostic factors, and nomograms for distant metastasis in patients with malignant pleural mesothelioma: A population-based retrospective study

Journal of International Medical Research
Objectives Malignant pleural mesothelioma is a rare and aggressive thoracic tumor with a poor prognosis, wherein distant metastasis is associated with the lowest survival rates.
Quzhe Lu, Chao Liu, Meixiang Xu, Zhi Hu, Hui Yin, Jie Yang   +5 more
doaj   +1 more source

Mesothelioma of tunica vaginalis of "uncertain malignant potential" - an evolving concept: case report and review of the literature

Diagnostic Pathology, 2011
Mesothelioma of tunica vaginalis is a rare neoplasm, typically demonstrating frankly malignant morphology and aggressive behavior. Rare cases of well-differentiated papillary mesotheliomas have also been reported, which, in contrast, demonstrate indolent
Yilmaz Asli, Kulaga Andrew, Barr Richard, Trpkov Kiril   +3 more
doaj   +1 more source