Results 1 to 10 of about 13,919 (205)

BAP1 Suppresses Tumor Development by Inducing Ferroptosis Upon SLC7A11 Repression

Molecular and Cellular Oncology, 2019
The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive.
Boyi Gan, Yilei Zhang, Li Zhuang
exaly   +3 more sources

Inhibition of BAP1 Sensitizes Gastric Cancer Cells to 5-Fluorouracil by Promoting BIRC5 Degradation [PDF]

Pharmaceuticals
Background/Objectives: Gastric cancer is an aggressive malignancy with poor prognosis, and acquired resistance to 5-fluorouracil (5-FU) remains a major therapeutic challenge.
In-Ho Jeong, Yu-Jin Park, Min-Jee Kim, Eun Ju Lee, Byung Sik Kim, Hee-Sung Kim, Peter Chang-Whan Lee   +6 more
doaj   +2 more sources

Ovarian sex cord-stromal tumors are part of the BAP1-tumor predisposition syndrome: evidence from human carriers and mouse models [PDF]

npj Precision Oncology
Germline heterozygous BAP1 pathogenic/likely pathogenic (P/LP) variants are associated with the BAP1-tumor predisposition syndrome (BAP1-TPDS). This study evaluated evidence for an association between ovarian cancers and BAP1-TPDS.
Abdelrahman M. Elsayed, Yuwaraj Kadariya, Lindsey Byrne, Eleonora Sementino, Leigha Senter, Isabella Gray, Olivia Taylor, Asmaa Mosbeh, Naomi Canny, Ying L. Liu, Christa I. Nagel, Joseph McElroy, Rania Sheikh, Colleen M. Cebulla, Maria I. Carlo, Mohamed H. Abdel-Rahman, Joseph R. Testa   +16 more
doaj   +2 more sources

Diagnostics of BAP1-Tumor Predisposition Syndrome by a Multitesting Approach: A Ten-Year-Long Experience [PDF]

Diagnostics, 2022
Germline mutations in the tumor suppressor gene BRCA1-associated protein-1 (BAP1) lead to BAP1 tumor predisposition syndrome (BAP1-TPDS), characterized by high susceptibility to several tumor types, chiefly melanoma, mesothelioma, renal cell carcinoma ...
Marika Sculco, Marta La Vecchia, Anna Aspesi, Michela Giulia Clavenna, Michela Salvo, Giulia Borgonovi, Alessandra Pittaro, Gianluca Witel, Francesca Napoli, Angela Listì, Federica Grosso, Roberta Libener, Antonio Maconi, Ottavio Rena, Renzo Boldorini, Daniela Giachino, Paolo Bironzo, Antonella Maffè, Greta Alì, Lisa Elefanti, Chiara Menin, Luisella Righi, Cristian Tampieri, Giorgio Vittorio Scagliotti, Caterina Dianzani, Daniela Ferrante, Enrica Migliore, Corrado Magnani, Dario Mirabelli, Giuseppe Matullo, Irma Dianzani   +30 more
doaj   +2 more sources

Circumscribed Meningeal Melanocytic Neoplasms: CNS WHO Grade, Molecular Profile, and Clinical Outcomes. [PDF]

Brain Pathol
In this study including 31 circumscribed meningeal melanocytic neoplasms (melanocytoma, intermediate‐grade melanocytic tumor [IMT], and melanoma), overall survival (OS) differed significantly among the groups, with melanoma showing significantly worse OS than melanocytoma and IMT showing intermediate OS between melanocytoma and melanoma.
Zhu Y, Karbhari N, Kaufmann TJ, Raghunathan A, Ida CM, Zepeda-Mendoza CJ, Dryden IJ, Salamat S, Atherton C, Jenkins SM, Markovic SN, Sener UT, Giannini C.   +12 more
europepmc   +2 more sources

PRAME predicting outcome in uveal melanoma [PDF]

J Pathol Clin Res
Abstract Uveal melanoma (UM) is the most common primary intra‐ocular malignancy in adults and carries a high risk of metastatic disease, affecting approximately 50% of patients despite advances in local tumour control. PRAME (PReferentially expressed Antigen in MElanoma) has emerged as a marker for metastatic risk; however, evidence is largely derived ...
Owens S, Walsh N, Horgan N, Murtagh P, Hanratty K, Finegan G, Ivers L, Crown J, Kennedy S.   +8 more
europepmc   +2 more sources

BAP1 Loss Might Be a Predictive Biomarker for Immunotherapy Response in Pleural Mesothelioma [PDF]

Thoracic Cancer
Introduction Reliable predictive biomarkers for immune checkpoint inhibitors (ICIs) in pleural mesothelioma (PM) are lacking. Loss of BRCA1‐associated protein 1 (BAP1) is a frequent molecular alteration in PM and may influence the tumor immune ...
Reina Imase, Rie Sakakibara, Susumu Kirimura, Hironori Ishibashi, Kenichi Okubo, Yasunari Miyazaki   +5 more
doaj   +2 more sources

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy [PDF]

Advanced science
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Shen Y, Cao Z, Wang Z, Chen L, Zhang J, Zeng L, Tan B, Li H, Lai J, Lei J, Chen F, Lin P, Shao Z, Wang Z.   +13 more
europepmc   +2 more sources

Allele-Specific GNAQ Q209 Mutations Reveal Context-Dependent Oncogenic Programs in Uveal Melanoma. [PDF]

Pigment Cell Melanoma Res
Using matched immune‐competent, multistep uveal melanoma models, we show that GNAQ Q209L and Q209R mutations are not functionally equivalent. Q209L drives faster in vivo progression but reduces in vitro proliferation and migration, whereas Q209R promotes greater in vitro fitness and preferential FAK‐YAP activation, revealing an allele‐dependent ...
Jarajapu V, Neelature Sriramareddy S, Mecozzi N, Wang K, Karreth FA, Xu X.   +5 more
europepmc   +2 more sources

BAP1 and USP1 cooperate to regulate FANCD2 stability and cell proliferation in mesothelioma cells [PDF]

Cell Death and Disease
BRCA1-associated protein 1 (BAP1) is frequently inactivated in pleural mesothelioma and functions as a tumor suppressor through its deubiquitinating activity.
Koya Suzuki, Shinichi Kiyonari, Jo Nishino, Miki Takahashi, Yuna Kato, Miki Amano, Anna Ogiso, Tomohiro Akashi, Tohru Maeda, Norio Kaneda, Takashi Miida, Yutaka Kondo, Kenji Kadomatsu, Mamoru Kato, Koji Aoyama, Hiroshi Murakami, Yoshitaka Sekido, Yuko Murakami-Tonami   +17 more
doaj   +2 more sources