Results 1 to 10 of about 294,312 (244)

Uveal melanoma [PDF]

Nature Reviews Disease Primers, 2020
This PrimeView highlights the mechanisms underlying uveal melanoma, the most common primary intraocular malignancy in adults.
Laura Marshall
semanticscholar   +6 more sources

Darovasertib, a novel treatment for metastatic uveal melanoma

Frontiers in Pharmacology, 2023
The FDA granted orphan drug designation to darovasertib, a first-in-class oral, small molecular inhibitor of protein kinase C (PKC), for the treatment of uveal melanoma, on 2 May 2022.
Lei Cao, Shuzhen Chen, Rainie Sun, Rainie Sun, Charles R. Ashby, Liuya Wei, Zoufang Huang, Zhe-Sheng Chen   +7 more
doaj   +2 more sources

Uveal Melanoma Metastasis [PDF]

Cancers, 2021
Simple Summary Survival after diagnosis of metastatic uveal melanoma has not significantly improved over decades, most patients die within a year from diagnosis.
E. Rossi, Michela Croce, Francesco Reggiani, Giovanni Schinzari, Marianna Ambrosio, Rosaria Gangemi, Giampaolo Tortora, Ulrich Pfeffer, A. Amaro   +8 more
semanticscholar   +5 more sources

Metastatic uveal melanoma: The final frontier

Progress in Retinal and Eye Research, 2022
Treatment of primary intraocular uveal melanoma has developed considerably, its driver genes are largely unraveled, and the ways to assess its risk for metastases are very precise, being based on an international staging system and genetic data ...
Elina S Rantala, Micaela Hernberg, Sophie Piperno-Neumann   +2 more
exaly   +2 more sources

Differences and Similarities in Epidemiology and Risk Factors for Cutaneous and Uveal Melanoma

Medicina, 2023
Both cutaneous melanoma (CM) and uveal melanoma (UM) represent important causes of morbidity and mortality. In this review, we evaluate the available knowledge on the differences and similarities between cutaneous melanoma and uveal melanoma, focusing on
Daciana Elena Brănișteanu, Elena Porumb-Andrese, Alexandra Stărică, Anca Catalina Munteanu, Mihaela Paula Toader, Mihail Zemba, Vlad Porumb, Mihai Cozmin, Andreea Dana Moraru, Alin Codruț Nicolescu, Daniel Constantin Brănișteanu   +10 more
doaj   +2 more sources

Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations

Insights into Imaging, 2021
Uveal melanoma is a malignant neoplasm that derives from pigmented melanocytes of the uvea and involves, in order of decreasing prevalence, the choroid, ciliary body and iris.
Pietro Valerio Foti, Mario Travali, Renato Farina, Stefano Palmucci, Corrado Spatola, Luigi Raffaele, Vincenzo Salamone, Rosario Caltabiano, Giuseppe Broggi, Lidia Puzzo, Andrea Russo, Michele Reibaldi, Antonio Longo, Paolo Vigneri, Teresio Avitabile, Giovani Carlo Ettorre, Antonio Basile   +16 more
doaj   +2 more sources

Genetic Background Predicts Uveal Melanoma Patients’ Outcomes [PDF]

Ophthalmology Science
Objective: Single nucleotide polymorphisms (SNPs) in IRF4 and HERC2 are associated with risk for disomy or monosomy of chromosome 3 (D3 or M3) uveal melanoma (UM), respectively.
Thibault Verrier, PhD, Anaïs Le Ven, Alexandre Houy, Erwin Brosens, PhD, Emine Kilic, MD, PhD, Wishal D. Ramdas, MD, PhD, Tolga Bicer, MD, Agathe Garcia, PhD, Anne-Charlotte Lefranc, Sandra Vanhuele, Amanda F. Kahn, Gaelle Pierron, PhD, Alexandre Matet, MD, PhD, Nathalie Cassoux, MD, PhD, Chrystelle Colas, MD, PhD, Manuel Rodrigues, MD, PhD, Josselin Noirel, PhD, Marc-Henri Stern, MD PhD   +17 more
doaj   +2 more sources

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

Cancer Cell, 2019
SUMMARY: Activating mutations in GNAQ/GNA11, encoding Gαq G-proteins, are the cancer initiating oncogenes in uveal melanoma (UM). However, there are no effective therapies for UM.
Xiaodong Feng, Nadia Arang, Damiano Cosimo Rigiracciolo   +2 more
exaly   +2 more sources

Treatment of uveal melanoma: where are we now?

Therapeutic Advances in Medical Oncology, 2018
Uveal melanoma, a rare subset of melanoma, is the most common primary intraocular malignancy in adults. Despite effective primary therapy, nearly 50% of patients will develop metastatic disease.
Jessica Yang, Brian P Marr, Richard D Carvajal   +2 more
exaly   +2 more sources

Clinicopathologic features and survival outcomes of ocular melanoma: a series of 31 cases from a tertiary university hospital [PDF]

Journal of Pathology and Translational Medicine, 2022
Background We aimed to determine the effect of clinicopathologic features on overall survival among Caucasian ocular melanoma patients in the Central Anatolia region of Turkey. Methods This single-center study included conjunctival (n = 12) and uveal (n =
Selin Kestel, Feriha Pınar Uyar Göçün, Betül Öğüt, Özlem Erdem   +3 more
doaj   +1 more source