Results 1 to 10 of about 35,407 (190)

Uveal melanoma [PDF]

Nature Reviews Disease Primers, 2020
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. UMs are usually initiated by a mutation in GNAQ or GNA11, unlike cutaneous melanomas, which usually harbour a BRAF or NRAS mutation. The annual incidence in Europe and the USA is ~6 per million population per year.
Jager, M.J., Shields, C.L., Cebulla, C.M., Abdel-Rahman, M.H., Grossniklaus, H.E., Stern, M.H., Carvajal, R.D., Belfort, R.N., Jia, R.B., Shields, J.A., Damato, B.E.   +10 more
exaly   +11 more sources

Uveal melanoma cells utilize a novel route for transendothelial migration. [PDF]

PLoS ONE, 2014
Uveal melanoma arises in the eye, and it spreads to distant organs in almost half of patients, leading to a fatal outcome. To metastasize, uveal melanoma cells must transmigrate into and out of the microvasculature, crossing the monolayer of endothelial ...
Michael D Onken, Jinmei Li, John A Cooper   +2 more
doaj   +6 more sources

Genetic Background Predicts Uveal Melanoma Patients’ Outcomes [PDF]

Ophthalmology Science
Objective: Single nucleotide polymorphisms (SNPs) in IRF4 and HERC2 are associated with risk for disomy or monosomy of chromosome 3 (D3 or M3) uveal melanoma (UM), respectively.
Thibault Verrier, PhD, Anaïs Le Ven, Alexandre Houy, Erwin Brosens, PhD, Emine Kilic, MD, PhD, Wishal D. Ramdas, MD, PhD, Tolga Bicer, MD, Agathe Garcia, PhD, Anne-Charlotte Lefranc, Sandra Vanhuele, Amanda F. Kahn, Gaelle Pierron, PhD, Alexandre Matet, MD, PhD, Nathalie Cassoux, MD, PhD, Chrystelle Colas, MD, PhD, Manuel Rodrigues, MD, PhD, Josselin Noirel, PhD, Marc-Henri Stern, MD PhD   +17 more
doaj   +2 more sources

Uveal Melanoma Metastasis [PDF]

Cancers, 2021
Uveal melanoma (UM) is characterized by relatively few, highly incident molecular alterations and their association with metastatic risk is deeply understood. Nevertheless, this knowledge has so far not led to innovate therapies for the successful treatment of UM metastases or for adjuvant therapy, leaving survival after diagnosis of metastatic UM ...
Ernesto Rossi, Michela Croce, Francesco Reggiani, Giovanni Schinzari, Marianna Ambrosio, Rosaria Gangemi, Giampaolo Tortora, Ulrich Pfeffer, Adriana Amaro   +8 more
openaire   +4 more sources

Uveal Melanoma [PDF]

Cancers, 2019
Uveal melanoma (UM) is among the best characterized solid tumors [...]
Mariel Angelou Parulan, Shantha Amrith, Stephanie Ming Young, Eric Ting, Bingcheng Wu, Min En Nga, Gangadhara Sundar   +6 more
  +5 more sources

Functional and conformational impact of cancer-associated SF3B1 mutations depends on the position and the charge of amino acid substitution

Computational and Structural Biotechnology Journal, 2021
The hotspot mutations of SF3B1, the most frequently mutated splicing gene in cancers, contribute to oncogenesis by corrupting the mRNA splicing. Further SF3B1 mutations have been reported in cancers but their consequences remain unclear.
Christine Canbezdi, Malcy Tarin, Alexandre Houy, Dorine Bellanger, Tatiana Popova, Marc-Henri Stern, Sergio Roman-Roman, Samar Alsafadi   +7 more
doaj   +1 more source

Clinicopathologic features and survival outcomes of ocular melanoma: a series of 31 cases from a tertiary university hospital [PDF]

Journal of Pathology and Translational Medicine, 2022
Background We aimed to determine the effect of clinicopathologic features on overall survival among Caucasian ocular melanoma patients in the Central Anatolia region of Turkey. Methods This single-center study included conjunctival (n = 12) and uveal (n =
Selin Kestel, Feriha Pınar Uyar Göçün, Betül Öğüt, Özlem Erdem   +3 more
doaj   +1 more source

Minimally Invasive Treatment Options for Hepatic Uveal Melanoma Metastases

Diagnostics, 2023
Uveal melanoma is one of the most common primary intraocular malignancies that accounts for about 85% of all ocular melanomas. The pathophysiology of uveal melanoma is distinct from cutaneous melanoma and has separate tumor profiles.
Abin Sajan, Samuel Fordyce, Andrew Sideris, Connie Liou, Zeeshan Toor, John Filtes, Venkatesh Krishnasamy, Noor Ahmad, Stephen Reis, Sidney Brejt, Asad Baig, Shaheer Khan, Michael Caplan, David Sperling, Joshua Weintraub   +14 more
doaj   +1 more source

Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency

npj Precision Oncology, 2022
Inactivating mutations of MBD4 have been reported in subsets of various tumors. A deficiency of this DNA glycosylase, recognizing specifically T:G mismatch resulting from the deamination of methyl-cytosine, results in a hypermutated phenotype due to the ...
Thomas Chabot, Fariba Nemati, Aurélie Herbette, Alexandre Demeyer, Stéphane Dayot, Olivier Ganier, Samar Alsafadi, Sophie Gardrat, Pascale Mariani, Marie Luporsi, Maxime Corbé, Vincent Servois, Nathalie Cassoux, Didier Decaudin, Sergio Roman Roman, Elaine Del Nery, Sophie Piperno-Neumann, Marc-Henri Stern, Manuel Rodrigues   +18 more
doaj   +1 more source

An Orthotopic Model of Uveal Melanoma in Zebrafish Embryo: A Novel Platform for Drug Evaluation

Biomedicines, 2021
Uveal melanoma is a highly metastatic tumor, representing the most common primary intraocular malignancy in adults. Tumor cell xenografts in zebrafish embryos may provide the opportunity to study in vivo different aspects of the neoplastic disease and ...
Chiara Tobia, Daniela Coltrini, Roberto Ronca, Alessandra Loda, Jessica Guerra, Elisa Scalvini, Francesco Semeraro, Sara Rezzola   +7 more
doaj   +1 more source