The diagnosis of metastatic uveal melanoma. What has changed during 10 years?
Alʹmanah Kliničeskoj Mediciny, 2020 Uveal melanoma is the most common intraocular malignancy. Despite significant progress in the treatment of the primary tumor, uveal melanoma continues to be the most aggressive tumor due to its high potential for hematogenous metastatic spread.
E. E. Grishina +2 more
doaj +1 more source
Discover Oncology, 2022 Background The incidence of uveal melanoma increases with latitude. In this study, we examine the importance of latitude for uveal melanoma prognosis. Methods All uveal melanoma patients born in Sweden between 1947 and 1990 were included (n = 745).
Gustav Stålhammar +2 more
doaj +1 more source
Immunological backbone of uveal melanoma: is there a rationale for immunotherapy? [PDF]
, 2019 No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors.
Alessandra Cassano +24 more
core +1 more source
Osteopontin and `Melanoma Inhibitory Activity': Comparison of Two Serological Tumor Markers in Metastatic Uveal Melanoma Patients [PDF]
, 2009 Background: Evaluation of the protein osteopontin (OPN) as a potential new marker in comparison to melanoma inhibitory activity (MIA) for screening and detection of metastatic uveal melanoma. Methods: Plasma levels of 32 patients with uveal melanoma were
Haritoglou, Christos +5 more
core +1 more source
Epidemiology of uveal melanomas in Moscow
Alʹmanah Kliničeskoj Mediciny, 2017 Rationale: Melanoma of the uveal tract of the eye is among the most prevalent malignant intraocular tumors.Aim: To identify epidemiological characteristics of uveal melanoma in Moscow.Materials and methods: We performed a retrospective analysis of out ...
E. E. Grishina +2 more
doaj +1 more source
MiR-144 Inhibits Uveal Melanoma Cell Proliferation and Invasion by Regulating c-Met Expression. [PDF]
PLoS ONE, 2015 MicroRNAs (miRNAs) are a group endogenous small non-coding RNAs that inhibit protein translation through binding to specific target mRNAs. Recent studies have demonstrated that miRNAs are implicated in the development of cancer.
Lei Sun +5 more
doaj +1 more source
Transplantable melanomas in hamsters and gerbils as models for human melanoma : sensitization in melanoma radiotherapy : from animal models to clinical trials [PDF]
, 2018 The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption
Andrzej Słominski +11 more
core +1 more source
Scientific and clinical implications of genetic and cellular heterogeneity in uveal melanoma
Molecular Biomedicine, 2021 Here, we discuss the presence and roles of heterogeneity in the development of uveal melanoma. Both genetic and cellular heterogeneity are considered, as their presence became undeniable due to single cell approaches that have recently been used in uveal
Mark J. de Lange +2 more
doaj +1 more source
Инфекция и иммунитет, 2022 The aim of the study is to conduct a comparative analysis of percentages for peripheral blood effector lymphocyte subsets in patients with uveal melanoma manifested by recurrent and chronic herpesvirus infection.
N. V. Balatskaya +4 more
doaj +1 more source
Therapeutic applications of SAMMSON lncRNA inhibition in uveal melanoma [PDF]
, 2017 Uveal melanoma is the most common intraocular malignancy in adults. The lack of an effective treatment results in a median survival time less than one year for patients with metastatic disease.
De Paepe, Boel +7 more
core +5 more sources