Results 21 to 30 of about 294,312 (244)
Imaging of Uveal Melanoma—Current Standard and Methods in Development
Cancers, 2022 Simple Summary Uveal melanoma is the most prevalent intraocular tumor in adults, derived from melanocytes; the liver is the most common site of its metastases.
Małgorzata Solnik +10 more
semanticscholar +1 more source
Cancers, 2022 Simple Summary The development of uveal melanoma is a multifactorial and multi-step process, in which specific and recurrent mutations arise early. Among the recurrently mutated genes, GNAQ and GNA11 are involved in the process of carcinogenesis and are ...
Paula Silva-Rodríguez +5 more
semanticscholar +1 more source
The PEMDAC phase 2 study of pembrolizumab and entinostat in patients with metastatic uveal melanoma
Nature Communications, 2021 Preclinical studies have suggested that epigenetic therapy could enhance immunogenicity of cancer cells. We report the results of the PEMDAC phase 2 clinical trial (n = 29; NCT02697630) where the HDAC inhibitor entinostat was combined with the PD-1 ...
L. Ny +17 more
semanticscholar +1 more source
MITF in Normal Melanocytes, Cutaneous and Uveal Melanoma: A Delicate Balance
International Journal of Molecular Sciences, 2022 Microphthalmia-associated transcription factor (MITF) is an important regulator of melanogenesis and melanocyte development. Although it has been studied extensively in cutaneous melanoma, the role of MITF in uveal melanoma (UM) has not been explored in ...
M. Gelmi +4 more
semanticscholar +1 more source
Current molecular and clinical insights into uveal melanoma (Review)
International Journal of Oncology, 2021 Uveal melanoma (UM) represents the most prominent primary eye cancer in adults. With an incidence of approximately 5 cases per million individuals annually in the United States, UM could be considered a relatively rare cancer.
M. Fallico +9 more
semanticscholar +1 more source
Uveal melanoma cells utilize a novel route for transendothelial migration. [PDF]
PLoS ONE, 2014 Uveal melanoma arises in the eye, and it spreads to distant organs in almost half of patients, leading to a fatal outcome. To metastasize, uveal melanoma cells must transmigrate into and out of the microvasculature, crossing the monolayer of endothelial ...
Michael D Onken +2 more
doaj +1 more source
Uveal melanoma incidence trends in Canada: 1992–2010 vs. 2011–2017
Frontiers in Medicine, 2023 Background/aimsUveal melanoma is the most common type of non-cutaneous melanoma and the most common ocular malignancy in the adult population, especially affecting Caucasians (98% of cases).
Santina Conte +11 more
doaj +1 more source
Expert Review of Anticancer Therapy, 2022 Introduction Metastatic uveal melanoma is associated with poor prognosis and few treatment options. Tebentafusp recently became the first FDA-approved agent for metastatic uveal melanoma.
L. Chen, R. Carvajal
semanticscholar +1 more source
Long-term relative survival in uveal melanoma: a systematic review and meta-analysis
Communications Medicine, 2022 A large proportion of patients with uveal melanoma develop metastases and succumb to their disease. Reports on the size of this proportion vary considerably. PubMed, Web of Science and Embase were searched for articles published after 1980. Studies with ≥
Gustav Stålhammar +1 more
semanticscholar +1 more source
Inflammation in uveal melanoma [PDF]
Eye, 2012 Leukocytic infiltration is a common feature of human cancers, including those that develop in immunoprivileged sites, such as the eye. The infiltration of myeloid and T cells into tumours is part of the host response against cancer. In uveal melanoma, high densities of immune cells seem to be involved in tumour progression, as they are associated with ...
Bronkhorst, I.H.G., Jager, M.J.
openaire +4 more sources