Results 31 to 40 of about 294,312 (244)

Uveal Melanoma in Ireland [PDF]

Ocular Oncology and Pathology, 2018
<b><i>Purpose:</i></b> To report the clinical features and epidemiology of uveal melanoma in Ireland. <b><i>Methods:</i></b> This was an observational study of 253 patients with a new diagnosis of uveal melanoma between June 2010 and December 2015.
Caroline, Baily, Valerie, O'Neill, Mary, Dunne, Moya, Cunningham, Giuseppe, Gullo, Susan, Kennedy, Paul M, Walsh, Sandra, Deady, Noel, Horgan   +8 more
openaire   +2 more sources

Single-cell analysis reveals new evolutionary complexity in uveal melanoma

Nature Communications, 2020
Uveal melanoma (UM) is a highly metastatic cancer that, in contrast to cutaneous melanoma, is largely unresponsive to checkpoint immunotherapy. Here, we interrogate the tumor microenvironment at single-cell resolution using scRNA-seq of 59,915 tumor and ...
Michael A. Durante, Daniel A. Rodriguez, Stefan Kurtenbach, Jeffim N. Kuznetsov, Margaret I. Sanchez, Christina L. Decatur, H. Snyder, L. Feun, A. Livingstone, J. Harbour   +9 more
semanticscholar   +1 more source

A comparative transcriptomic analysis of uveal melanoma and normal uveal melanocyte. [PDF]

PLoS ONE, 2011
BACKGROUND: Uveal melanoma is the most common primary intraocular tumor in adults in western countries. It is associated with very severe visual morbidity and may lead to distant metastases even after successful treatment of the primary tumor.
Jianhong An, Haolei Wan, Xiangtian Zhou, Dan-Ning Hu, Ledan Wang, Lili Hao, Dongsheng Yan, Fanjun Shi, Zhonglou Zhou, Jiao Wang, Songnian Hu, Jun Yu, Jia Qu   +12 more
doaj   +1 more source

Tolerability and efficacy of chemosaturation in combination with systemic therapy for metastatic uveal melanoma. [PDF]

Int J Cancer
What's new? Uveal melanoma is the most common primary intraocular cancer in adults, and up to half of patients develop metastatic disease, predominantly in the liver, where prognosis remains poor despite promising treatment options. In this study, the authors evaluated the safety and efficacy of administering systemic therapy within 40 days of liver ...
Kasteleiner P, Grözinger G, Schmehl J, Flatz L, Forschner A.   +4 more
europepmc   +2 more sources

Uveal melanoma diagnosis and current treatment options (Review)

Experimental and Therapeutic Medicine, 2021
Uveal melanoma is a rare condition accounting for only 5% of all primary melanoma cases. Still, it is the most frequently diagnosed primary intraocular malignant tumor in adults.
D. Brănișteanu, C. Bogdănici, D. Brănișteanu, M. Mărănducă, M. Zemba, F. Balta, Cătălina Ioana Brănişteanu, A. Moraru   +7 more
semanticscholar   +1 more source

The diagnosis of metastatic uveal melanoma. What has changed during 10 years?

Alʹmanah Kliničeskoj Mediciny, 2020
Uveal melanoma is the most common intraocular malignancy. Despite significant progress in the treatment of the primary tumor, uveal melanoma continues to be the most aggressive tumor due to its high potential for hematogenous metastatic spread.
E. E. Grishina, E. A. Stepanova, A. M. Bogatyrev   +2 more
doaj   +1 more source

Synthetic Lethal Screens Reveal Co-Targeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma

Clinical Cancer Research, 2021
Purpose: Uveal melanoma is the most common eye cancer in adults. Approximately 50% of patients with uveal melanoma develop metastatic uveal melanoma (mUM) in the liver, even after successful treatment of the primary lesions.
J. Paradis, Monica Acosta, R. Saddawi-Konefka, Ayush Kishore, Frederico Gomes, Nadia Arang, Manoela Tiago, S. Coma, Simone Lubrano, Xingyu Wu, Kyle Ford, Chi-Ping Day, G. Merlino, P. Mali, J. Pachter, Takami Sato, A. Aplin, J. Gutkind   +17 more
semanticscholar   +1 more source

Immunotherapy for Uveal Melanoma [PDF]

Melanoma Management, 2016
Uveal melanoma (UM) is a rare cancer with a high mortality rate. In comparison to cutaneous melanoma, UM has unique immunological features. Arising in the immune suppressive environment of the eye, it maintains immune resistance once metastatic. This is considered a major obstacle for successful immunotherapy in UM.
Dae Won, Kim, Jaime, Anderson, Sapna P, Patel   +2 more
openaire   +2 more sources

The prognostic implication of latitude in uveal melanoma: a nationwide observational cohort study of all patients born in Sweden between 1947 and 1989

Discover Oncology, 2022
Background The incidence of uveal melanoma increases with latitude. In this study, we examine the importance of latitude for uveal melanoma prognosis. Methods All uveal melanoma patients born in Sweden between 1947 and 1990 were included (n = 745).
Gustav Stålhammar, Pete A. Williams, Tomas Landelius   +2 more
doaj   +1 more source

The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway.

Archives of Pathology & Laboratory Medicine, 2020
CONTEXT.— There have been major advances in the understanding of melanoma since the last revision of the World Health Organization (WHO) classification in 2006.
D. Elder, B. Bastian, I. Cree, D. Massi, R. Scolyer   +4 more
semanticscholar   +1 more source