Results 41 to 50 of about 195,013 (218)

Hemorrhagic choroidal detachment as the presenting sign of uveal melanoma

American Journal of Ophthalmology Case Reports, 2021
Purpose: To describe two cases of medium-sized uveal melanoma presenting with hemorrhagic choroidal detachments. Observations: The first case is a 39-year-old man who presented with choroidal hemorrhage and angle closure glaucoma. The second case is a 42-
Yewlin E. Chee, Raghu Mudumbai, Steven S. Saraf, Thellea Leveque, Verena S. Grieco, Monique A. Mogensen, Rebecca A. Yoda, Luis F. Gonzalez-Cuyar, Andrew W. Stacey   +8 more
doaj   +1 more source

Genetic Background Predicts Uveal Melanoma Patients’ Outcomes

Ophthalmology Science
Objective: Single nucleotide polymorphisms (SNPs) in IRF4 and HERC2 are associated with risk for disomy or monosomy of chromosome 3 (D3 or M3) uveal melanoma (UM), respectively.
Thibault Verrier, PhD, Anaïs Le Ven, Alexandre Houy, Erwin Brosens, PhD, Emine Kilic, MD, PhD, Wishal D. Ramdas, MD, PhD, Tolga Bicer, MD, Agathe Garcia, PhD, Anne-Charlotte Lefranc, Sandra Vanhuele, Amanda F. Kahn, Gaelle Pierron, PhD, Alexandre Matet, MD, PhD, Nathalie Cassoux, MD, PhD, Chrystelle Colas, MD, PhD, Manuel Rodrigues, MD, PhD, Josselin Noirel, PhD, Marc-Henri Stern, MD PhD   +17 more
doaj   +1 more source

Necrotic uveal melanoma presenting as orbital cellulitis with intraocular hemorrhage: A case report

American Journal of Ophthalmology Case Reports, 2019
Purpose: To report a case of necrotic uveal melanoma presenting as orbital cellulitis with an intraocular hemorrhage. Observations: A 61 year-old non-verbal male presented with a two-week history of right eyelid swelling and erythema unresponsive to ...
Alexa L. Li, Julia Y. Kang, Duncan E. Berry, Krishna B. Patel, Andrew M. Hendrick   +4 more
doaj   +1 more source

Mda-9/syntenin is expressed in uveal melanoma and correlates with metastatic progression. [PDF]

PLoS ONE, 2012
Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of the patients, with a high lethality rate. Identification of patients at high risk of metastases may provide indication for a frequent follow-up for early detection of ...
Rosaria Gangemi, Valentina Mirisola, Gaia Barisione, Marina Fabbi, Antonella Brizzolara, Francesco Lanza, Carlo Mosci, Sandra Salvi, Marina Gualco, Mauro Truini, Giovanna Angelini, Simona Boccardo, Michele Cilli, Irma Airoldi, Paola Queirolo, Martine J Jager, Antonio Daga, Ulrich Pfeffer, Silvano Ferrini   +18 more
doaj   +1 more source

Stereotactic Radiotherapy in Uveal Melanoma

, 2014
Uveal melanoma is the most common primary malignant intraocular neoplasm in adults. The aims of treatment of the uveal melanoma are to prevent the metastatic spread of the disease and to preserve as much useful vision as possible.
Ela Delikgöz Soykut, Yıldız Yükselen Güney, Ayşen Dizman   +2 more
core   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Uveal melanoma incidentally diagnosed with neuroimaging, a case series of 3 patients

Radiology Case Reports, 2022
Uveal melanoma is the most common primary intraocular malignancy and can occur in the choroid, the ciliary body, or the iris. It is most often diagnosed based on clinical examination by an ophthalmologist. Nearly all patients present with visual symptoms.
Mai Tsukikawa, MD, Babatunde Akinpelu, MD, Pattana Wangaryattawanich, MD, Kathryn Scherpelz, MDPhD, Andrew W. Stacey, MDMS   +4 more
doaj   +1 more source

Brachytherapy and endoresection in the treatment of choroidal melanoma a review of patients treated in South Africa [PDF]

, 2012
Includes bibliographical references.This study is a retrospective cohort analysis of patients undergoing two different treatment modalities (brachytherapy and endoresection) for medium sized choroidal melanoma.
Rice, James C
core   +1 more source

Base-excision repair pathway shapes 5-methylcytosine deamination signatures in pan-cancer genomes

Nature Communications
Transition of cytosine to thymine in CpG dinucleotides is the most frequent type of mutation in cancer. This increased mutability is commonly attributed to the spontaneous deamination of 5-methylcytosine (5mC), which is normally repaired by the base ...
André Bortolini Silveira, Alexandre Houy, Olivier Ganier, Begüm Özemek, Sandra Vanhuele, Anne Vincent-Salomon, Nathalie Cassoux, Pascale Mariani, Gaelle Pierron, Serge Leyvraz, Damian Rieke, Alberto Picca, Franck Bielle, Marie-Laure Yaspo, Manuel Rodrigues, Marc-Henri Stern   +15 more
doaj   +1 more source

Identify the signature genes for diagnose of uveal melanoma by weight gene co-expression network analysis [PDF]

International Journal of Ophthalmology, 2015
AIM: To identify and understand the relationship between co-expression pattern and clinic traits in uveal melanoma, weighted gene co-expression network analysis (WGCNA) is applied to investigate the gene expression levels and patient clinic features ...
Kai Shi, Zhi-Tong Bing, Gui-Qun Cao, Ling Guo, Ya-Na Cao, Hai-Ou Jiang, Mei-Xia Zhang   +6 more
doaj   +1 more source