Results 41 to 50 of about 294,312 (244)
Estimation of the timing of BAP1 mutation in uveal melanoma progression
Scientific Reports, 2021 Uveal melanoma is the most common primary intraocular malignancy. A vast majority of metastasizing tumors have mutations in the BAP1 gene. Here, we investigate the spatiotemporal timing of these mutations.
Ogul E. Uner +4 more
semanticscholar +1 more source
Ocular Oncology and Pathology, 2020 <b><i>Introduction:</i></b> Multiple uveal melanoma is a rare occurrence and includes bilateral melanoma, unilateral multiple/multifocal melanoma, or melanoma with metastasis to the ipsilateral or contralateral eye. <b><i>Methods:</i></b> A chart review of patients diagnosed with uveal melanoma between ...
Wajiha J. Kheir +2 more
openaire +2 more sources
MiR-144 Inhibits Uveal Melanoma Cell Proliferation and Invasion by Regulating c-Met Expression. [PDF]
PLoS ONE, 2015 MicroRNAs (miRNAs) are a group endogenous small non-coding RNAs that inhibit protein translation through binding to specific target mRNAs. Recent studies have demonstrated that miRNAs are implicated in the development of cancer.
Lei Sun +5 more
doaj +1 more source
Инфекция и иммунитет, 2022 The aim of the study is to conduct a comparative analysis of percentages for peripheral blood effector lymphocyte subsets in patients with uveal melanoma manifested by recurrent and chronic herpesvirus infection.
N. V. Balatskaya +4 more
doaj +1 more source
Insights into Imaging, 2021 Therapy of uveal melanoma aims to preserve the eye and its function and to avoid metastatic dissemination. The treatment choice is difficult and must keep into account several factors; the therapeutic strategy of uveal melanoma should therefore be ...
P. Foti +18 more
semanticscholar +1 more source
Epidemiology of uveal melanomas in Moscow
Alʹmanah Kliničeskoj Mediciny, 2017 Rationale: Melanoma of the uveal tract of the eye is among the most prevalent malignant intraocular tumors.Aim: To identify epidemiological characteristics of uveal melanoma in Moscow.Materials and methods: We performed a retrospective analysis of out ...
E. E. Grishina +2 more
doaj +1 more source
Modelling uveal melanoma [PDF]
British Journal of Ophthalmology, 1999 There has been no consistent pattern reported on how mortality for uveal melanoma varies with age. This information can be useful to model the complexity of the disease. The authors have examined ocular cancer trends, as an indirect measure for uveal melanoma mortality, to see how rates vary with age and to compare the results with their other studies ...
A J, Foss +3 more
openaire +2 more sources
Scientific and clinical implications of genetic and cellular heterogeneity in uveal melanoma
Molecular Biomedicine, 2021 Here, we discuss the presence and roles of heterogeneity in the development of uveal melanoma. Both genetic and cellular heterogeneity are considered, as their presence became undeniable due to single cell approaches that have recently been used in uveal
Mark J. de Lange +2 more
doaj +1 more source
Nivolumab and Ipilimumab in Metastatic Uveal Melanoma: Results From a Single-Arm Phase II Study.
Journal of Clinical Oncology, 2020 PURPOSE Metastatic uveal melanoma has poor overall survival (OS) and no approved systemic therapy options. Studies of single-agent immunotherapy regimens have shown minimal benefit.
M. Pelster +11 more
semanticscholar +1 more source
Gp-100 as a Novel Therapeutic Target in Uveal Melanoma
Cancers, 2021 Simple Summary Glycoprotein 100 (Gp-100) is a protein highly expressed in melanoma tissue that has recently been effectively targeted by tebentafusp, a first-in-class bispecific protein of the immune-mobilizing monoclonal T cell receptors against cancer (
D. Martínez-Pérez +4 more
semanticscholar +1 more source