Results 61 to 70 of about 294,312 (244)

BAP1 methylation: a prognostic marker of uveal melanoma metastasis

npj Precision Oncology, 2021
Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by ...
Mathieu F. Bakhoum, Ellis J. Curtis, Michael H. Goldbaum, Paul S. Mischel   +3 more
doaj   +1 more source

Necrotic uveal melanoma presenting as orbital cellulitis with intraocular hemorrhage: A case report

American Journal of Ophthalmology Case Reports, 2019
Purpose: To report a case of necrotic uveal melanoma presenting as orbital cellulitis with an intraocular hemorrhage. Observations: A 61 year-old non-verbal male presented with a two-week history of right eyelid swelling and erythema unresponsive to ...
Alexa L. Li, Julia Y. Kang, Duncan E. Berry, Krishna B. Patel, Andrew M. Hendrick   +4 more
doaj   +1 more source

Hemorrhagic choroidal detachment as the presenting sign of uveal melanoma

American Journal of Ophthalmology Case Reports, 2021
Purpose: To describe two cases of medium-sized uveal melanoma presenting with hemorrhagic choroidal detachments. Observations: The first case is a 39-year-old man who presented with choroidal hemorrhage and angle closure glaucoma. The second case is a 42-
Yewlin E. Chee, Raghu Mudumbai, Steven S. Saraf, Thellea Leveque, Verena S. Grieco, Monique A. Mogensen, Rebecca A. Yoda, Luis F. Gonzalez-Cuyar, Andrew W. Stacey   +8 more
doaj   +1 more source

Mda-9/syntenin is expressed in uveal melanoma and correlates with metastatic progression. [PDF]

PLoS ONE, 2012
Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of the patients, with a high lethality rate. Identification of patients at high risk of metastases may provide indication for a frequent follow-up for early detection of ...
Rosaria Gangemi, Valentina Mirisola, Gaia Barisione, Marina Fabbi, Antonella Brizzolara, Francesco Lanza, Carlo Mosci, Sandra Salvi, Marina Gualco, Mauro Truini, Giovanna Angelini, Simona Boccardo, Michele Cilli, Irma Airoldi, Paola Queirolo, Martine J Jager, Antonio Daga, Ulrich Pfeffer, Silvano Ferrini   +18 more
doaj   +1 more source

Uveal melanoma incidentally diagnosed with neuroimaging, a case series of 3 patients

Radiology Case Reports, 2022
Uveal melanoma is the most common primary intraocular malignancy and can occur in the choroid, the ciliary body, or the iris. It is most often diagnosed based on clinical examination by an ophthalmologist. Nearly all patients present with visual symptoms.
Mai Tsukikawa, MD, Babatunde Akinpelu, MD, Pattana Wangaryattawanich, MD, Kathryn Scherpelz, MDPhD, Andrew W. Stacey, MDMS   +4 more
doaj   +1 more source

Uveal melanoma: Estimating prognosis

Indian Journal of Ophthalmology, 2015
Uveal melanoma is the most common primary malignant tumor of the eye in adults, predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet this malignancy is associated with relatively high mortality secondary to ...
Swathi Kaliki, Carol L Shields, Jerry A Shields   +2 more
doaj   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Base-excision repair pathway shapes 5-methylcytosine deamination signatures in pan-cancer genomes

Nature Communications
Transition of cytosine to thymine in CpG dinucleotides is the most frequent type of mutation in cancer. This increased mutability is commonly attributed to the spontaneous deamination of 5-methylcytosine (5mC), which is normally repaired by the base ...
André Bortolini Silveira, Alexandre Houy, Olivier Ganier, Begüm Özemek, Sandra Vanhuele, Anne Vincent-Salomon, Nathalie Cassoux, Pascale Mariani, Gaelle Pierron, Serge Leyvraz, Damian Rieke, Alberto Picca, Franck Bielle, Marie-Laure Yaspo, Manuel Rodrigues, Marc-Henri Stern   +15 more
doaj   +1 more source

Identify the signature genes for diagnose of uveal melanoma by weight gene co-expression network analysis [PDF]

International Journal of Ophthalmology, 2015
AIM: To identify and understand the relationship between co-expression pattern and clinic traits in uveal melanoma, weighted gene co-expression network analysis (WGCNA) is applied to investigate the gene expression levels and patient clinic features ...
Kai Shi, Zhi-Tong Bing, Gui-Qun Cao, Ling Guo, Ya-Na Cao, Hai-Ou Jiang, Mei-Xia Zhang   +6 more
doaj   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source