Results 61 to 70 of about 35,407 (190)

Proton Therapy for Uveal Melanoma in 43 Juvenile Patients: Long-Term Results. [PDF]

, 2014
PURPOSE: To examine the metastatic and survival rates, eye retention probability, and the visual outcomes of juvenile patients after proton beam radiotherapy (PBRT) for uveal melanoma (UM).
Bergin, C., Goitein, G., Petrovic, A., Schalenbourg, A., Zografos, L.   +4 more
core   +1 more source

Uveal Melanoma [PDF]

Cancer Control, 1998
Background Malignant melanoma of the uveal tract is a rare malignancy but a significant cause of mortality and visual loss. Approximately 50% of patients diagnosed with a melanoma of the choroid or ciliary body will die of the disease within 15 years of enucleation.
openaire   +1 more source

Prognostic analysis of uveal melanoma based on the characteristic genes of M2-type macrophages in the tumor microenvironment

BMC Bioinformatics, 2023
Uveal melanoma arises from stromal melanocytes and is the most prevalent primary intraocular tumor in adults. It poses a significant diagnostic and therapeutic challenge due to its high malignancy and early onset of metastases. In recent years, there has
Li Fu, Qun Huang, Yongfeng Wu, Diang Chen   +3 more
doaj   +1 more source

Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors

Nature Communications, 2018
Hypermutated tumors respond more favorably to checkpoint inhibitor-based immune therapy. Here, the authors describe a new hypermutated phenotype due to germline mutations and subsequent somatic loss of heterozygosity of MBD4, and a dramatic response to ...
Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Alice Fiévet, Sophie Gardrat, Raymond L. Barnhill, Tatiana Popova, Vincent Servois, Aurore Rampanou, Aurore Mouton, Stéphane Dayot, Virginie Raynal, Michèle Galut, Marc Putterman, Sarah Tick, Nathalie Cassoux, Sergio Roman-Roman, François-Clément Bidard, Olivier Lantz, Pascale Mariani, Sophie Piperno-Neumann, Marc-Henri Stern   +21 more
doaj   +1 more source

Uveal melanoma: Therapeutic consequences of doubling times and irradiation results; a review [PDF]

, 1992
Thirty-six of 39 published calculated doubling times (Td's) of uveal melanomas appeared to be longer than 60 days. Metastatic death occurs 35–40 Td's after dissemination.
Manschot, W.A., Strik, R. (Roel) van
core   +1 more source

Metastatic disease in polyploid uveal melanoma patients is associated with BAP1 mutations [PDF]

, 2016
PURPOSE. Most of the uvea melanoma (UM) display a near-diploid (normal, ~2N) karyotype with only a few chromosomal changes. In contrast to these simple aberrations 18% of the UM samples show a polyploid character (>2N) and this was associated with an ...
Beverloo, H.B. (Berna), Brüggenwirth, H.T. (Hennie), Dubbink, H.J. (Erik Jan), Kiliç, E. (Emine), Klein, A. (Annelies) de, Marion, R. (Ronald) van, Mensink, H.W. (Hanneke), Naus, N.C. (Nicole), Paridaens, A.D.A. (Dion), Smit, K.N. (Kyra), Vaarwater, J. (Jolanda), Verdijk, R.M. (Robert), Yavuzyigitoglu, S. (Serdar)   +12 more
core   +1 more source

Tissue-Based Microarray Expression of Genes Predictive of Metastasis in Uveal Melanoma and Differentially Expressed in Metastatic Uveal Melanoma

Journal of Ophthalmic & Vision Research, 2013
Purpose: To screen the microarray expression of CDH1, ECM1, EIF1B, FXR1, HTR2B, ID2, LMCD1, LTA4H, MTUS1, RAB31, ROBO1, and SATB1 genes which are predictive of primary uveal melanoma metastasis, and NFKB2, PTPN18, MTSS1, GADD45B, SNCG, HHIP, IL12B, CDK4,
Hakan Demirci, David David Reed, Victor M Elner   +2 more
doaj  

Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma [PDF]

, 2017
Uveal melanoma (UM) is a rare aggressive intraocular tumour with a propensity for liver metastases, occurring in ∼50% of patients. The tumour suppressor BAP1 is considered to be key in UM progression.
Abdel-Rahman, MH, Cebulla, CM, Coulson, J, Coupland, SE, Farquhar, N, Heimann, H, Kalirai, H, Krishna, Y, Sacco, JJ, Taktak, A, Thornton, S   +10 more
core   +1 more source

Genetic evolution of uveal melanoma guides the development of an inflammatory microenvironment [PDF]

, 2017
Experimental cancer immunology and ...
Gregorius P. M. Luyten, Gülçin Gezgin, Martine J. Jager, Mehmet Dogrusöz, Pieter A. van der Velden, Robert M. Verdijk, Sjoerd H. van der Burg, T. Huibertus van Essen, Thorbald van Hall, Vonn Walter, Wilhelmina G. M. Kroes   +10 more
core   +4 more sources

Uveal Melanoma

Oncology Times, 2021
Uvea melanomas (UM) are rare tumors of the eye, they are, nevertheless, associated with significant morbidity and mortality. In the first part of this thesis, we describe the prognostic value of clinical and histopathologic characteristics, locoregional anatomic factors, and chromosomal alterations in UM.
openaire   +4 more sources