Results 61 to 70 of about 195,013 (218)

The genetics of uveal melanoma: current insights

, 2016
Hildur Helgadottir,1,2 Veronica Höiom1 1Department of Oncology and Pathology, Karolinska Institutet, 2Department of Oncology, Karolinska University Hospital, Stockholm, Sweden Abstract: Uveal melanoma (UM) is the most common malignant eye tumor in ...
Helgadottir H, Hoiom, V, Helgadottir, H,, Höiom V   +3 more
core   +1 more source

Metastatic Melanoma to the Urinary Bladder of Ocular Origin Accompanied with Primary Cutaneous Melanoma: Diagnostic Challenge—A Report of a Case

Case Reports in Pathology, 2017
Metastases of melanoma to the urinary bladder are infrequent. Even rarer are metastases to the urinary bladder from uveal melanoma, with only 3 cases published in the literature so far. Herein we present a case of a 77-year-old male patient who presented
Constantine Theocharides, Kyriakos Chatzopoulos, Dimitrios Papanikolaou, Vasileios Siokas, Ioannis Amplianitis, Athanasios Papanikolaou   +5 more
doaj   +1 more source

LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition

EMBO Molecular Medicine, 2023
Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout screen, which revealed the LKB1‐SIK2 module in restraining uveal melanoma tumorigenesis ...
Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon‐Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan‐Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub   +31 more
doaj   +1 more source

Circumscribed Meningeal Melanocytic Neoplasms: CNS WHO Grade, Molecular Profile, and Clinical Outcomes

Brain Pathology, EarlyView.
In this study including 31 circumscribed meningeal melanocytic neoplasms (melanocytoma, intermediate‐grade melanocytic tumor [IMT], and melanoma), overall survival (OS) differed significantly among the groups, with melanoma showing significantly worse OS than melanocytoma and IMT showing intermediate OS between melanocytoma and melanoma.
Yi Zhu, Nishika Karbhari, Timothy J. Kaufmann, Aditya Raghunathan, Cristiane M. Ida, Cinthya J. Zepeda‐Mendoza, Ian J. Dryden, Shahriar Salamat, Chathu Atherton, Sarah M. Jenkins, Svetomir N. Markovic, Ugur T. Sener, Caterina Giannini   +12 more
wiley   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus

, 2017
Uveal melanoma, a rare malignant tumor of the eye, is predominantly observed in populations of European ancestry. A genome-wide association study of 259 uveal melanoma patients compared to 401 controls all of European ancestry revealed a candidate locus ...
Jean-François Deleuze, Mobuchon, Lenha, Battistella, Aude, Stern, Marc-Henri, Olivier Cussenot, Alexandre Houy, Cassoux, Nathalie, Ghislaine Scelo, Cox, David, G, Cancel-Tassin, Géraldine, Nathalie Cassoux, Deleuze, Jean-François, Alexia Renoud, Milder, Maud, Géraldine Cancel-Tassin, Marc-Henri Stern, Houy, Alexandre, Boland, Anne, Lenha Mobuchon, Bardel, Claire, Besse, Céline, Maud Milder, David G. Cox, Anne Boland, Renoud, Alexia, Scelo, Ghislaine, Céline Besse, Aude Battistella, Cussenot, Olivier, Claire Bardel, Olivier Delattre, Delattre, Olivier   +31 more
core   +1 more source

MRI of Uveal Melanoma [PDF]

Cancers, 2019
Uveal Melanoma (UM) is the most common primary malignant ocular tumor. The high soft tissue contrast and spatial resolution, and the possibility of generating 3D volumetric and functional images, make Magnetic Resonance Imaging (MRI) a valuable diagnostic imaging technique in UM.
Teresa A. Ferreira, Lorna Grech Fonk, Myriam G. Jaarsma-Coes, Guido G. R. van Haren, Marina Marinkovic, Jan-Willem M. Beenakker   +5 more
openaire   +4 more sources

Prognostic analysis of uveal melanoma based on the characteristic genes of M2-type macrophages in the tumor microenvironment

BMC Bioinformatics, 2023
Uveal melanoma arises from stromal melanocytes and is the most prevalent primary intraocular tumor in adults. It poses a significant diagnostic and therapeutic challenge due to its high malignancy and early onset of metastases. In recent years, there has
Li Fu, Qun Huang, Yongfeng Wu, Diang Chen   +3 more
doaj   +1 more source

SLAMF6 Enhances the Efficacy of Anti‐PD‐L1 Immunotherapy in CRC Through the STAT1/CXCL10 Signaling Axis

Cancer Science, EarlyView.
SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu, Xinhui Lv, Shunhao Zhang, Yafang Chen, Sicong Liu, Feiyang Song, Chunmei Zhao, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors

Nature Communications, 2018
Hypermutated tumors respond more favorably to checkpoint inhibitor-based immune therapy. Here, the authors describe a new hypermutated phenotype due to germline mutations and subsequent somatic loss of heterozygosity of MBD4, and a dramatic response to ...
Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Alice Fiévet, Sophie Gardrat, Raymond L. Barnhill, Tatiana Popova, Vincent Servois, Aurore Rampanou, Aurore Mouton, Stéphane Dayot, Virginie Raynal, Michèle Galut, Marc Putterman, Sarah Tick, Nathalie Cassoux, Sergio Roman-Roman, François-Clément Bidard, Olivier Lantz, Pascale Mariani, Sophie Piperno-Neumann, Marc-Henri Stern   +21 more
doaj   +1 more source