Results 81 to 90 of about 294,312 (244)

Metastatic Melanoma to the Urinary Bladder of Ocular Origin Accompanied with Primary Cutaneous Melanoma: Diagnostic Challenge—A Report of a Case

Case Reports in Pathology, 2017
Metastases of melanoma to the urinary bladder are infrequent. Even rarer are metastases to the urinary bladder from uveal melanoma, with only 3 cases published in the literature so far. Herein we present a case of a 77-year-old male patient who presented
Constantine Theocharides, Kyriakos Chatzopoulos, Dimitrios Papanikolaou, Vasileios Siokas, Ioannis Amplianitis, Athanasios Papanikolaou   +5 more
doaj   +1 more source

LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition

EMBO Molecular Medicine, 2023
Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout screen, which revealed the LKB1‐SIK2 module in restraining uveal melanoma tumorigenesis ...
Sarah Proteau, Imène Krossa, Chrystel Husser, Maxime Guéguinou, Federica Sella, Karine Bille, Marie Irondelle, Mélanie Dalmasso, Thibault Barouillet, Yann Cheli, Céline Pisibon, Nicole Arrighi, Sacha Nahon‐Estève, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M Mazure, Frédéric Bost, Stéphanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan‐Charvet, Mitchell P Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub   +31 more
doaj   +1 more source

Patients presenting with stage IV uveal melanoma: Lessons learned

Indian Journal of Ophthalmology, 2022
Challenges persist in identifying patients with stage IV uveal melanoma. While clinical, histopathologic, and genetic features of the primary tumor have been shown to provide prognostic value for assessing metastatic risk, biopsy-related genetic analyses
Gaurav Garg, Tero T Kivelä, Paul T Finger   +2 more
doaj   +1 more source

The 9th Edition of the UICC TNM Classification of Malignant Tumours: Updates and Rationale for Change

International Journal of Cancer, EarlyView.
ABSTRACT The standard for assessing and recording the extent of the tumour, a necessity for most malignancies, is the Tumour Node Metastases (TNM) classification. The Union for International Cancer Control (UICC) TNM committee has defined this since the early 1950s.
James D. Brierley, Liesbet J. Van Eycken, Meredith E. Giuliani, Brian A. Rous, Shao Hui Huang, Hisao Asamura, Mary K. Gospodarowicz, Anne W. Lee, Brian O'Sullivan   +8 more
wiley   +1 more source

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.

Cancer Cell, 2018
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3).
A. G. Robertson, J. Shih, J. Shih, C. Yau, E. Gibb, Junna Oba, K. Mungall, J. Hess, Vladislav Uzunangelov, Vonn Walter, Vonn Walter, Ludmila V. Danilova, T. Lichtenberg, M. Kucherlapati, P. K. Kimes, M. Tang, A. Penson, Özgün Babur, Rehan Akbani, C. Bristow, K. Hoadley, L. Iype, Matthew T. Chang, Matthew T. Chang, M. Abdel-Rahman, Adrian Ally, J. Auman, M. Balasundaram, S. Balu, C. Benz, R. Beroukhim, I. Birol, T. Bodenheimer, Jay Bowen, R. Bowlby, Denise Brooks, R. Carlsen, C. Cebulla, A. Cherniack, A. Cherniack, L. Chin, Juok Cho, E. Chuah, Sudha Chudamani, C. Cibulskis, K. Cibulskis, L. Cope, S. Coupland, T. DeFreitas, J. Demchok, L. Desjardins, Noreen Dhalla, B. Esmaeli, Ina Felau, M. Ferguson, S. Frazer, S. Gabriel, J. Gastier-Foster, Nils Gehlenborg, M. Gerken, J. Gershenwald, G. Getz, K. Griewank, E. Grimm, D. Hayes, A. Hegde, David I Heiman, Carmen Helsel, Shital Hobensack, R. Holt, A. Hoyle, Xin Hu, C. Hutter, M. Jager, S. Jefferys, Corbin D. Jones, Steven J. M. Jones, Cyriac Kandoth, K. Kasaian, Jaegil Kim, R. Kucherlapati, E. Lander, Mike S. Lawrence, A. Lazar, Semin Lee, K. Leraas, Pei Lin, Jia Liu, Wenbin Liu, Laxmi Lolla, Yiling Lu, Yussanne Ma, Harshad S. Mahadeshwar, O. Mariani, M. Marra, Michael Mayo, S. Meier, S. Meng, M. Meyerson, P. Mieczkowski, G. Mills, Richard A. Moore, Lisle E. Mose, A. Mungall, Bradley A. Murray, R. Naresh, M. Noble, A. Pantazi, Michael G Parfenov, Peter J. Park, J. Parker, C. Perou, T. Pihl, R. Pilarski, A. Protopopov, Amie Radenbaugh, Karan Rai, N. Ramirez, X. Ren, Sheila M. Reynolds, J. Roach, S. Roman-Roman, J. Roszik, S. Sadeghi, G. Saksena, X. Sastre, D. Schadendorf, J. Schein, L. Schoenfield, S. Schumacher, J. Seidman, S. Seth, Geetika Sethi, Margi Sheth, Yan Shi, C. Shields, I. Shmulevich, J. Simons, Arun D. Singh, Payal Sipahimalani, Tara J. Skelly, H. Sofia, Matthew G. Soloway, Xingzhi Song, Marc-Henri Stern, Joshua M. Stuart, Qiang Sun, Huandong Sun, Angela Tam, Donghui Tan, Jiabin Tang, R. Tarnuzzer, B. Taylor, N. Thiessen, V. Thorsson, Kane Tse, Umadevi Veluvolu, R. Verhaak, D. Voet, Yunhu Wan, Zhining Wang, J. Weinstein, M. Wilkerson, M. Williams, L. Wise, S. Woodman, Tina Wong, Ye Wu, Liming Yang, Lixing Yang, J. Zenklusen, Jiashan Zhang, Hailei Zhang, E. Zmuda   +173 more
semanticscholar   +1 more source

ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression

Autophagy, 2020
Long noncoding RNAs (lncRNAs) are proved to be critical regulators in numerous cellular processes. However, the potential involvement of lncRNAs in macroautophagy/autophagy is largely unknown.
Peng Li, Jie He, Zhi Yang, S. Ge, He Zhang, Q. Zhong, Xianqun Fan   +6 more
semanticscholar   +1 more source

MRI of Uveal Melanoma [PDF]

Cancers, 2019
Uveal Melanoma (UM) is the most common primary malignant ocular tumor. The high soft tissue contrast and spatial resolution, and the possibility of generating 3D volumetric and functional images, make Magnetic Resonance Imaging (MRI) a valuable diagnostic imaging technique in UM.
Teresa A. Ferreira, Lorna Grech Fonk, Myriam G. Jaarsma-Coes, Guido G. R. van Haren, Marina Marinkovic, Jan-Willem M. Beenakker   +5 more
openaire   +4 more sources

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Testican‐1‐MMP axis in tumour extracellular matrix (ECM) remodelling: interaction dynamics analysis and an in silico perspective

The Journal of Pathology, EarlyView.
Abstract The extracellular matrix (ECM) plays a pivotal role in facilitating tumour development, invasiveness, metastasis, and immunoevasive processes through dynamic ECM remodelling processes. Testican‐1 (SPOCK1), an excretory matricellular proteoglycan, is suggested to exert a role in the facilitation of ECM remodelling processes through interacting ...
Sepideh Youssefi, Kiarash Saleki, Prerna Kadam, Amirreza Mazloomi, Abhik Mukherjee, Lodewijk V Dekker, Abdolrahman S Nateri   +6 more
wiley   +1 more source

Prognostic analysis of uveal melanoma based on the characteristic genes of M2-type macrophages in the tumor microenvironment

BMC Bioinformatics, 2023
Uveal melanoma arises from stromal melanocytes and is the most prevalent primary intraocular tumor in adults. It poses a significant diagnostic and therapeutic challenge due to its high malignancy and early onset of metastases. In recent years, there has
Li Fu, Qun Huang, Yongfeng Wu, Diang Chen   +3 more
doaj   +1 more source