Results 71 to 80 of about 195,013 (218)

Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions

, 2018
Beatrice Y Brewington,1 Yusra F Shao,2 Fredrick H Davidorf,1 Colleen M Cebulla1 1Havener Eye Institute, Department of Ophthalmology and Visual Science, Ohio State University, 2Medical Student Research Program, The Ohio State University College of ...
Cebulla CM, Yusra F Shao, Brewington BY, Beatrice Y Brewington, Frederick H Davidorf, Colleen M Cebulla, Davidorf FH, Shao YF   +7 more
core   +1 more source

Patient‐reported patterns in follow‐up care of metastatic uveal melanoma: A survey in specialized dermato‐oncological centers

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Recent therapeutic advances, such as tebentafusp, may prolong survival of metastatic uveal melanoma (mUM) patients. Early detection of metastases during follow‐up (FU) may be clinically relevant; however, FU remains non‐standardized.
Susanne Dugas‐Breit, Markus V. Heppt, Andrea Forschner, Cindy Franklin, Christoffer Gebhardt, Mirjana Ziemer, Ralf Gutzmer, Maximilian Lammer, Konstantin Drexler, Jessica C. Hassel, the DeCOG committee „Uveal melanoma“   +10 more
wiley   +1 more source

The biology of uveal melanoma [PDF]

Cancer and Metastasis Reviews, 2017
Uveal melanoma (UM), a rare cancer of the eye, is distinct from cutaneous melanoma by its etiology, the mutation frequency and profile, and its clinical behavior including resistance to targeted therapy and immune checkpoint blockers. Primary disease is efficiently controlled by surgery or radiation therapy, but about half of UMs develop distant ...
Amaro, Adriana, Gangemi, Rosaria, Piaggio, Francesca, Angelini, Giovanna, Barisione, Gaia, Ferrini, Silvano, Pfeffer, Ulrich   +6 more
openaire   +2 more sources

Tissue-Based Microarray Expression of Genes Predictive of Metastasis in Uveal Melanoma and Differentially Expressed in Metastatic Uveal Melanoma

Journal of Ophthalmic & Vision Research, 2013
Purpose: To screen the microarray expression of CDH1, ECM1, EIF1B, FXR1, HTR2B, ID2, LMCD1, LTA4H, MTUS1, RAB31, ROBO1, and SATB1 genes which are predictive of primary uveal melanoma metastasis, and NFKB2, PTPN18, MTSS1, GADD45B, SNCG, HHIP, IL12B, CDK4,
Hakan Demirci, David David Reed, Victor M Elner   +2 more
doaj  

Clinical descriptive and long‐term outcome of melanocytic uveal lesions in young dogs: 40 cases (45 eyes) including 13 cases of sector iridectomy

Veterinary Ophthalmology, Volume 28, Issue 2, Page 371-385, March 2025.
Abstract Purpose To describe the clinical features surgical technique, early and long‐term outcome with or without surgery, and histopathological findings of melanocytic anterior uveal lesions in young dogs. Methods Medical records of dogs at a guide dog facility removed from training due to a pigmented iris lesion were reviewed from 2014 to 2021 ...
Valerie Liliane Dufour, Julie A. Cohen, Charles‐Antoine Assenmacher, Dolores M. Holle, Amy C. Durham, Gustavo D. Aguirre, Keiko Miyadera   +6 more
wiley   +1 more source

Diagnostic Utility of PRAME Immunohistochemistry for Distinguishing Acral Melanoma From Acral Melanocytic Nevi

Journal of Cutaneous Pathology, Volume 53, Issue 12, Page 1148-1158, December 2026.
ABSTRACT Introduction Preferentially expressed antigen in melanoma (PRAME) immunohistochemistry helps distinguish non‐acral melanocytic lesions, but few studies have addressed its value in acral lesions. We aimed to identify an optimal PRAME cut‐off score to differentiate acral melanoma (AM) from acral melanocytic nevi (AMN).
Kritsada Phatcharamaneepakorn, Panitta Sitthinamsuwan, Penvadee Pattanaprichakul, Manasmon Chairatchaneeboon, Nutcha Yodrabum   +4 more
wiley   +1 more source

PD-1 expression on uveal melanoma induces tumor proliferation and predicts poor patient survival

The International Journal of Biological Markers, 2020
Introduction: Uveal melanoma is one of the most common primary intraocular malignant tumors with poor prognosis and limited treatments. Programmed cell death receptor-1 (PD-1) blockade represents the primary treatment strategy of immune checkpoint ...
Zhongming Jiang, Yuexiang Yan, Juan Dong, Lingling Duan   +3 more
doaj   +1 more source

Investigating Risk Factors for Delayed Melanoma Recurrence Beyond 5 Years Post‐Primary Tumor Diagnosis

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Patients undergoing treatment for cutaneous melanoma are generally considered cured after a period of 5 years, since most recurrences manifest within three to 5 years. However, some patients can present with a delayed recurrence of melanoma beyond a 10‐year timeframe.
Kaspar Itin, Rebecca Lapides, Soumya Paria, Babak Saravi, Alina. M. Torrez, Lara Valeska Maul, Michael Wang‐Evers, Alexander A. Navarini, Dieter Manstein, Beata Kun, Leticia Szadai, Judit Olàh, Eszter Baltas, Rolland Gyulai, Peter Hollo, Grzegorz Sarek, Istvan B. Németh, Kaustubh Adhikari, Elisabeth Roider   +18 more
wiley   +1 more source

T Cell-Engaging Bispecific Antibodies Targeting gp100 and PRAME: Expanding Application from Uveal Melanoma to Cutaneous Melanoma

Pharmaceutics
Uveal melanoma represents a rare and aggressive subtype of melanoma with limited treatment options and poor prognosis, especially in the metastatic setting.
Robin Reschke, Alexander H. Enk, Jessica C. Hassel   +2 more
doaj   +1 more source

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, Volume 159, Issue 9, Page 2290-2299, 1 November 2026.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source