Results 71 to 80 of about 35,407 (190)

Posterior uveal melanoma in adolescents and children: current perspectives

Clinical Ophthalmology, 2018
Matthew V Fry,1 James J Augsburger,1 June Hall,2 Zélia M Corrêa21Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA; 2Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore ...
Fry MV, Augsburger JJ, Hall J, Corrêa ZM   +3 more
doaj  

PD-1 expression on uveal melanoma induces tumor proliferation and predicts poor patient survival

The International Journal of Biological Markers, 2020
Introduction: Uveal melanoma is one of the most common primary intraocular malignant tumors with poor prognosis and limited treatments. Programmed cell death receptor-1 (PD-1) blockade represents the primary treatment strategy of immune checkpoint ...
Zhongming Jiang, Yuexiang Yan, Juan Dong, Lingling Duan   +3 more
doaj   +1 more source

Shedding light on melanins within in situ human eye melanocytes using 2-photon microscopy profiling techniques. [PDF]

, 2019
Choroidal melanocytes (HCMs) are melanin-producing cells in the vascular uvea of the human eye (iris, ciliary body and choroid). These cranial neural crest-derived cells migrate to populate a mesodermal microenvironment, and display cellular functions ...
Cherepanoff, Svetlana, Conway, Robert Max, Gratton, Enrico, Macmillan, Alexander, Madigan, Michele C, Sitiwin, Ephrem, Whan, Renee   +6 more
core  

T Cell-Engaging Bispecific Antibodies Targeting gp100 and PRAME: Expanding Application from Uveal Melanoma to Cutaneous Melanoma

Pharmaceutics
Uveal melanoma represents a rare and aggressive subtype of melanoma with limited treatment options and poor prognosis, especially in the metastatic setting.
Robin Reschke, Alexander H. Enk, Jessica C. Hassel   +2 more
doaj   +1 more source

Chromosomal Gains and Losses in Uveal Melanomas Detected by Comparative Genomic Hybridization [PDF]

, 1994
Eleven uveal melanomas were analyzed using comparative genomic hybridization (CGH). The most abundant genetic changes were loss of chromosome 3, overrepresentation of 6p, loss of 6q, and multiplication of 8q.
Becher, Reinhard, Bornfeld, N., Cremer, Thomas, Horsthemke, B., Jauch, Anna, Manoir, Stanislas du, Prescher, G., Speicher, Michael R.   +7 more
core  

Somatostatin Receptors as Molecular Targets in Human Uveal Melanoma [PDF]

, 2018
K
Andrew V. Schally, Csaba Szasz, Erzsebet Szabo, Gabor Halmos, Gabor Mehes, Gabor Olah, Harda Kristóf Máté (1989-) (gyógyszerész), Klara Fodor, Kristof Harda, Zsuzsanna Szabo   +9 more
core   +2 more sources

Current Therapies and Potential Strategies for Uveal Melanoma

Drugs and Drug Candidates
Background/Objectives: Uveal melanoma (UM) is a rare but deadly ocular cancer. This review summarizes the characteristics of uveal melanoma and current therapeutic options for primary uveal melanoma and metastatic uveal melanoma, and introduces recent ...
Sarah Scoles, Sanjay Ganesh, Kaori H. Yamada   +2 more
doaj   +1 more source

Characterization, treatment, and outcome of uveal melanoma in the first two years of life

Hematology/Oncology and Stem Cell Therapy, 2015
BACKGROUND AND OBJECTIVES: Features and characteristics of uveal melanoma are well described in adults, but little is known about the presentation of uveal melanoma in infancy. DESIGN: Systematic literature review.
Yacoub A Yousef, Mais Alkilany
doaj   +1 more source

Comprehensive Genetic Landscape of Uveal Melanoma by Whole-Genome Sequencing. [PDF]

, 2016
Uveal melanoma (UM) is a rare intraocular tumor that, similar to cutaneous melanoma, originates from melanocytes. To gain insights into its genetics, we performed whole-genome sequencing at very deep coverage of tumor-control pairs in 33 samples (24 ...
Ciriello, G., Cisarova, K., El Zaoui, I., Klein, R., Leyvraz, S., Moulin, A.P., Nicolas, M., Pescini-Gobert, R., Raynaud, F., Riggi, N., Rimoldi, D., Rivolta, C., Royer-Bertrand, B., Schalenbourg, A., Speiser, D., Torsello, M., Vallat, L., Zografos, L.   +17 more
core   +1 more source

Imatinib mesylate alters the expression of genes related to disease progression in an animal model of uveal melanoma [PDF]

, 2011
Imatinib mesylate (IM) is a compound that inhibits both BCR-ABL tyrosine kinase and c-kit receptors. Tyrosine kinases are important in cellular signaling and mediate major cellular processes such as proliferation, differentiation, apoptosis, attachment ...
Abourbih, Daniel, Antecka, Emilia, Belfort Neto, Rubens, Burnier Júnior, Miguel Nascente, Castiglione, Enzo, Di Cesare, Sebastian, Fernandes, Bruno F., Isenberg, Jordan, Maloney, Shawn, Martins, Claudia   +9 more
core   +2 more sources