Results 11 to 20 of about 35,407 (190)
Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p. [PDF]
PLoS ONE, 2017 Growing evidences indicated that Long noncoding RNAs (lncRNAs) played important roles in tumor initiation and progression. However, the function and mechnism of lncRNA ferritin heavy chain 1 pseudogene 3 (FTH1P3) remain unknown in uveal melanoma.
Xiaoli Zheng +5 more
doaj +1 more source
Biology of advanced uveal melanoma and next steps for clinical therapeutics [PDF]
, 2014 Uveal melanoma is the most common intraocular malignancy although it is a rare subset of all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with widely divergent patient outcomes.
Bastian, BC +17 more
core +4 more sources
Darovasertib, a novel treatment for metastatic uveal melanoma
Frontiers in Pharmacology, 2023 The FDA granted orphan drug designation to darovasertib, a first-in-class oral, small molecular inhibitor of protein kinase C (PKC), for the treatment of uveal melanoma, on 2 May 2022.
Lei Cao +7 more
doaj +1 more source
Cancer Treatment Reviews, 2012 Uveal melanoma, which arises from melanocytes residing in the stroma, is the most common primary intraocular tumor in adults. Up to 50% of patients with primary uveal melanoma will ultimately develop distant metastasis, the liver being involved in up to 90% of individuals and the median survival reported to be 4-5 months.
Queirolo P, Caltabiano G, Spagnolo F
+7 more sources
Journal of Skin Cancer, 2011 Uveal melanoma is the most common primary intraocular malignancy and the leading primary intraocular disease which can be fatal in adults. In this paper epidemiologic, pathogenetic, and clinical aspects of uveal melanoma are discussed. Despite the advance in local ocular treatments, there has been no change in patient survival for three decades ...
Vasilios P. Papastefanou +1 more
openaire +3 more sources
Ocular Oncology and Pathology, 2020 <b><i>Introduction:</i></b> Multiple uveal melanoma is a rare occurrence and includes bilateral melanoma, unilateral multiple/multifocal melanoma, or melanoma with metastasis to the ipsilateral or contralateral eye. <b><i>Methods:</i></b> A chart review of patients diagnosed with uveal melanoma between ...
Wajiha J. Kheir +2 more
openaire +2 more sources
Uveal melanoma incidence trends in Canada: 1992–2010 vs. 2011–2017
Frontiers in Medicine, 2023 Background/aimsUveal melanoma is the most common type of non-cutaneous melanoma and the most common ocular malignancy in the adult population, especially affecting Caucasians (98% of cases).
Santina Conte +11 more
doaj +1 more source
A comparative transcriptomic analysis of uveal melanoma and normal uveal melanocyte. [PDF]
PLoS ONE, 2011 BACKGROUND: Uveal melanoma is the most common primary intraocular tumor in adults in western countries. It is associated with very severe visual morbidity and may lead to distant metastases even after successful treatment of the primary tumor.
Jianhong An +12 more
doaj +1 more source
Modelling uveal melanoma [PDF]
British Journal of Ophthalmology, 1999 There has been no consistent pattern reported on how mortality for uveal melanoma varies with age. This information can be useful to model the complexity of the disease. The authors have examined ocular cancer trends, as an indirect measure for uveal melanoma mortality, to see how rates vary with age and to compare the results with their other studies ...
A J, Foss +3 more
openaire +2 more sources
Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma. [PDF]
, 2017 Patients with metastatic uveal melanoma usually die within 1 year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis.
Aplin, Andrew E. +8 more
core +2 more sources