Results 11 to 20 of about 294,312 (244)

Functional and conformational impact of cancer-associated SF3B1 mutations depends on the position and the charge of amino acid substitution

Computational and Structural Biotechnology Journal, 2021
The hotspot mutations of SF3B1, the most frequently mutated splicing gene in cancers, contribute to oncogenesis by corrupting the mRNA splicing. Further SF3B1 mutations have been reported in cancers but their consequences remain unclear.
Christine Canbezdi, Malcy Tarin, Alexandre Houy, Dorine Bellanger, Tatiana Popova, Marc-Henri Stern, Sergio Roman-Roman, Samar Alsafadi   +7 more
doaj   +1 more source

Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma.

New England Journal of Medicine, 2021
BACKGROUND Uveal melanoma is a disease that is distinct from cutaneous melanoma, with a low tumor mutational burden and a 1-year overall survival of approximately 50% in patients with metastatic uveal melanoma.
P. Nathan, J. Hassel, P. Rutkowski, J. Baurain, M. Butler, M. Schlaak, R. Sullivan, S. Ochsenreither, R. Dummer, J. Kirkwood, A. Joshua, J. Sacco, A. Shoushtari, M. Orloff, J. Piulats, M. Milhem, A. Salama, B. Curti, L. Demidov, L. Gastaud, C. Mauch, M. Yushak, R. Carvajal, O. Hamid, S. Abdullah, C. Holland, H. Goodall, S. Piperno-Neumann   +27 more
semanticscholar   +1 more source

Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma

New England Journal of Medicine, 2023
BACKGROUND Tebentafusp, a T-cell receptor–bispecific molecule that targets glycoprotein 100 and CD3, is approved for adult patients who are positive for HLA-A*02:01 and have unresectable or metastatic uveal melanoma.
J. Hassel, S. Piperno-Neumann, Piotr Rutkowski, J. Baurain, M. Schlaak, Marcus O. Butler, R.J. Sullivan, R. Dummer, John M. Kirkwood, M. Orloff, J.J. Sacco, S. Ochsenreither, A.M. Joshua, L. Gastaud, B. Curti, J. Piulats, April K.S. Salama, A. Shoushtari, Lev V. Demidov, Mohammed M Milhem, B. Chmielowski, Kevin B. Kim, R. Carvajal, O. Hamid, L. Collins, Koustubh Ranade, C. Holland, Constance Pfeiffer, P. Nathan   +28 more
semanticscholar   +1 more source

Current management of uveal melanoma: A review

Clinical and Experimental Ophthalmology, 2023
Uveal melanoma is the most frequent primary intraocular cancer in adulthood and is mostly localised to the choroid. It can be treated using radiation therapy, laser therapy, local resection and enucleation, with the best results achieved by combining ...
H. Bai, J. Bosch, Ludwig M Heindl
semanticscholar   +1 more source

Clinical and molecular response to tebentafusp in previously treated patients with metastatic uveal melanoma: a phase 2 trial

Nature Medicine, 2022
In patients with previously treated metastatic uveal melanoma, the historical 1 year overall survival rate is 37% with a median overall survival of 7.8 months.
R. Carvajal, M. Butler, A. Shoushtari, J. Hassel, A. Ikeguchi, L. Hernandez-Aya, P. Nathan, O. Hamid, J. Piulats, M. Rioth, Douglas B. Johnson, J. Luke, E. Espinosa, S. Leyvraz, L. Collins, H. Goodall, K. Ranade, C. Holland, S. Abdullah, J. Sacco, Takami Sato   +20 more
semanticscholar   +1 more source

Minimally Invasive Treatment Options for Hepatic Uveal Melanoma Metastases

Diagnostics, 2023
Uveal melanoma is one of the most common primary intraocular malignancies that accounts for about 85% of all ocular melanomas. The pathophysiology of uveal melanoma is distinct from cutaneous melanoma and has separate tumor profiles.
Abin Sajan, Samuel Fordyce, Andrew Sideris, Connie Liou, Zeeshan Toor, John Filtes, Venkatesh Krishnasamy, Noor Ahmad, Stephen Reis, Sidney Brejt, Asad Baig, Shaheer Khan, Michael Caplan, David Sperling, Joshua Weintraub   +14 more
doaj   +1 more source

Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency

npj Precision Oncology, 2022
Inactivating mutations of MBD4 have been reported in subsets of various tumors. A deficiency of this DNA glycosylase, recognizing specifically T:G mismatch resulting from the deamination of methyl-cytosine, results in a hypermutated phenotype due to the ...
Thomas Chabot, Fariba Nemati, Aurélie Herbette, Alexandre Demeyer, Stéphane Dayot, Olivier Ganier, Samar Alsafadi, Sophie Gardrat, Pascale Mariani, Marie Luporsi, Maxime Corbé, Vincent Servois, Nathalie Cassoux, Didier Decaudin, Sergio Roman Roman, Elaine Del Nery, Sophie Piperno-Neumann, Marc-Henri Stern, Manuel Rodrigues   +18 more
doaj   +1 more source

An Orthotopic Model of Uveal Melanoma in Zebrafish Embryo: A Novel Platform for Drug Evaluation

Biomedicines, 2021
Uveal melanoma is a highly metastatic tumor, representing the most common primary intraocular malignancy in adults. Tumor cell xenografts in zebrafish embryos may provide the opportunity to study in vivo different aspects of the neoplastic disease and ...
Chiara Tobia, Daniela Coltrini, Roberto Ronca, Alessandra Loda, Jessica Guerra, Elisa Scalvini, Francesco Semeraro, Sara Rezzola   +7 more
doaj   +1 more source

Uveal Melanoma [PDF]

Journal of Skin Cancer, 2011
Uveal melanoma is the most common primary intraocular malignancy and the leading primary intraocular disease which can be fatal in adults. In this paper epidemiologic, pathogenetic, and clinical aspects of uveal melanoma are discussed. Despite the advance in local ocular treatments, there has been no change in patient survival for three decades ...
Vasilios P. Papastefanou, Victoria M. L. Cohen   +1 more
openaire   +3 more sources

Long non-coding RNA FTH1P3 facilitates uveal melanoma cell growth and invasion through miR-224-5p. [PDF]

PLoS ONE, 2017
Growing evidences indicated that Long noncoding RNAs (lncRNAs) played important roles in tumor initiation and progression. However, the function and mechnism of lncRNA ferritin heavy chain 1 pseudogene 3 (FTH1P3) remain unknown in uveal melanoma.
Xiaoli Zheng, Hongwei Tang, Xiaofeng Zhao, Yamei Sun, Yanfang Jiang, Yonghua Liu   +5 more
doaj   +1 more source