Results 11 to 20 of about 195,013 (218)
Cancers, 2019 Uveal melanoma (UM) is among the best characterized solid tumors [...
Ulrich Pfeffer
core +3 more sources
Uveal melanoma: Estimating prognosis
Indian Journal of Ophthalmology, 2015 Uveal melanoma is the most common primary malignant tumor of the eye in adults, predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet this malignancy is associated with relatively high mortality secondary to ...
Swathi Kaliki +2 more
doaj +2 more sources
Posterior uveal melanoma in adolescents and children: current perspectives
Clinical Ophthalmology, 2018 Matthew V Fry,1 James J Augsburger,1 June Hall,2 Zélia M Corrêa21Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA; 2Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore ...
Fry MV +3 more
doaj +1 more source
Aberrant Splicing in Uveal Melanoma Pathogenesis [PDF]
, 2022 Uveal Melanoma are a distinct type of rare eye malignancy. SF3B1 mutated uveal melanoma are a distinct type of these tumors which are characterized by clinical, chromosomal and genetic ...
Drabarek, Wojtek
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Cancer Treatment Reviews, 2012 Uveal melanoma, which arises from melanocytes residing in the stroma, is the most common primary intraocular tumor in adults. Up to 50% of patients with primary uveal melanoma will ultimately develop distant metastasis, the liver being involved in up to ...
Spagnolo F, Caltabiano G, Queirolo P
core +4 more sources
BAP1 methylation: a prognostic marker of uveal melanoma metastasis [PDF]
npj Precision Oncology, 2021 Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by ...
Mathieu F. Bakhoum +3 more
doaj +2 more sources
Allele-Specific GNAQ Q209 Mutations Reveal Context-Dependent Oncogenic Programs in Uveal Melanoma. [PDF]
Pigment Cell Melanoma ResUsing matched immune‐competent, multistep uveal melanoma models, we show that GNAQ Q209L and Q209R mutations are not functionally equivalent. Q209L drives faster in vivo progression but reduces in vitro proliferation and migration, whereas Q209R promotes greater in vitro fitness and preferential FAK‐YAP activation, revealing an allele‐dependent ...
Jarajapu V +5 more
europepmc +2 more sources
Uveal Melanoma Metastasis [PDF]
Cancers, 2021 Uveal melanoma (UM) is characterized by relatively few, highly incident molecular alterations and their association with metastatic risk is deeply understood. Nevertheless, this knowledge has so far not led to innovate therapies for the successful treatment of UM metastases or for adjuvant therapy, leaving survival after diagnosis of metastatic UM ...
Ernesto Rossi +8 more
openaire +4 more sources
Survival from Uveal Melanoma in England and Wales 1986 to 2001 [PDF]
, 2007 Purpose. To analyse survival from uveal melanoma diagnosed in England and Wales during 1986-1999 and followed up to 2001. Methods. Data from the National Cancer Registry at the Office for National Statistics were analysed.
Rachet, B. +3 more
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Journal of Skin Cancer, 2011 Uveal melanoma is the most common primary intraocular malignancy and the leading primary intraocular disease which can be fatal in adults. In this paper epidemiologic, pathogenetic, and clinical aspects of uveal melanoma are discussed. Despite the advance in local ocular treatments, there has been no change in patient survival for three decades ...
Vasilios P. Papastefanou +1 more
openaire +3 more sources