Results 11 to 20 of about 13,919 (205)

BAP1-defficient breast cancer in a patient with BAP1 cancer syndrome [PDF]

Breast Cancer, 2022
AbstractBAP1 cancer syndrome is a rare and highly penetrant hereditary cancer predisposition. Uveal melanoma, mesothelioma, renal cell carcinoma (RCC) and cutaneous melanoma are considered BAP1 cancer syndrome core cancers, whereas association with breast cancer has previously been suggested but not confirmed so far.
Ana Blatnik, Domen Ribnikar, Vita Šetrajčič Dragoš, Srdjan Novaković, Vida Stegel, Biljana Grčar Kuzmanov, Nina Boc, Barbara Perić, Petra Škerl, Gašper Klančar, Mateja Krajc   +10 more
core   +9 more sources

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer

Genome Biology, 2022
Background BRCA1-associated protein 1 (BAP1) is an ubiquitin carboxy-terminal hydrolase, which forms a multi-protein complex with different epigenetic factors, such as ASXL1-3 and FOXK1/2.
Natsumi Tsuboyama, Aileen Patricia Szczepanski, Zibo Zhao, Lu Wang   +3 more
doaj   +3 more sources

Loss of BAP1 Expression Is Very Rare in Pancreatic Ductal Adenocarcinoma. [PDF]

PLoS ONE, 2016
BACKGROUND:Pancreatic cancer is both common and highly lethal and therefore new biomarkers or potential targets for treatment are needed. Loss of BRCA associated protein-1 (BAP1) expression has been found in up to a quarter of intrahepatic ...
Michael Tayao, Juliana Andrici, Mahtab Farzin, Adele Clarkson, Loretta Sioson, Nicole Watson, Terence C Chua, Tamara Sztynda, Jaswinder S Samra, Anthony J Gill   +9 more
doaj   +3 more sources

BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer

Journal of Experimental & Clinical Cancer Research
Background The vast majority of pancreatic cancers have been shown to be insensitive to single-agent immunotherapy. Exploring the mechanisms of immune resistance and implementing combination therapeutic strategies are crucial for PDAC patients to derive ...
Weiwei Yuan, Qiyue Zhang, Yuhan Zhao, Wentao Xia, Shilin Yin, Xueyi Liang, Taoyu Chen, Gaofeng Li, Yanshen Liu, Zhiqiang Liu, Jinxi Huang   +10 more
doaj   +2 more sources

Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1 [PDF]

Frontiers in Immunology, 2021
BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, via deubiquitination of histone H2AK119ub and other substrates. BAP1 is an important tumor suppressor in human,
Yun Hsiao Lin, Yun Hsiao Lin, Yue Liang, Yue Liang, HanChen Wang, HanChen Wang, HanChen Wang, HanChen Wang, Lin Tze Tung, Lin Tze Tung, Michael Förster, Michael Förster, Poorani Ganesh Subramani, Poorani Ganesh Subramani, Javier M. Di Noia, Javier M. Di Noia, Javier M. Di Noia, Javier M. Di Noia, Simon Clare, David Langlais, David Langlais, David Langlais, David Langlais, Anastasia Nijnik, Anastasia Nijnik   +24 more
doaj   +3 more sources

Histologically Diverse BAP1-Deficient Melanocytic Tumors in a Patient With BAP1 Tumor Predisposition Syndrome

The American Journal of Dermatopathology, 2020
Abstract: BRCA1-associated protein-1 (BAP1)-deficient cutaneous tumors are common in patients with BAP1 tumor predisposition syndrome, frequently presenting before other associated neoplasms, and can serve as an early marker to identify individuals with this disease. The typical lesions are dermal based and composed of a combination of larger
Louw, A., Creaney, J., Thomas, A., Van Vliet, C., Harvey, N.T., Wood, B.A., Mesbah Ardakani, N.   +6 more
openaire   +3 more sources

BAP1 In Solid Tumors

Future Oncology, 2019
One of the most attractive cancer-related genes under investigation is BAP1. Reasons of this growing interest are related to the wide spectrum of pathways directly or indirectly modulated by this gene and shared by several solid tumors. Programmed cell-death, cell metabolisms, immune cells development, ferroptosis and defects in DNA damage response are
Di Nunno V., Frega G., Santoni M., Gatto L., Fiorentino M., Montironi R., Battelli N., Brandi G., Massari F.   +8 more
openaire   +4 more sources

Bap1 promotes osteoclast function by metabolic reprogramming [PDF]

, 2023
Treatment of osteoporosis most commonly diminishes osteoclast number which suppresses bone formation thus compromising fracture prevention. Bone formation is not suppressed, however, when bone degradation is reduced by retarding osteoclast functional ...
nidhi rohatgi (15406957), Patrick L. Collins (15174160), Kevin Cho (11128228), Anwesha Dey (14944236), wei zou (15406966), Eric Tycksen (3524450), Yongjia Li (1510861), SL Teitelbaum (7935839), Carl J. DeSelm (15388434), Gary Patti (11128231), Gaurav Pandey (15406977)   +10 more
core   +2 more sources

BAP1 Tumour Predisposition Syndrome Due to Whole BAP1 Gene Deletion

Case Reports in Genetics, 2022
BRCA-1-associated protein-1 (BAP1) tumour predisposition syndrome (BAP1-TPDS) is a dominant hereditary cancer syndrome. The full spectrum of associated malignancies is yet to be fully characterised. We detail the phenotypic features of the first reported family with a whole BAP1 gene deletion.
Dinusha Pandithan, Sonja Klebe, Grace McKavanagh, Lesley Rawlings, Sui Yu, Jillian Nicholl, Nicola Poplawski   +6 more
openaire   +4 more sources

Hereditary Renal Cell Carcinoma Syndromes

Société Internationale d’Urologie Journal, 2022
A number of germline syndromes that predispose affected individuals to develop renal cancer have been described, each with unique manifestations, histopathology, and tumor behavior.
Jodie K. Maranchie, Brian M. Schuch, Gennady Bratslavsky, Eamonn R. Maher   +3 more
doaj   +1 more source