Results 1 to 10 of about 14,755 (179)
Metabolites, 2023 Quercetin is a flavonol found in edible plants and possesses a significant anticancer activity. This study explored the mechanism by which quercetin prevented liver cancer via inducing apoptosis in HepG2 cells.
Hui Guan +8 more
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The Two Sides of YY1 in Cancer: A Friend and a Foe
Frontiers in Oncology, 2019 Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional activation and repression of many genes associated with multiple cellular processes including cellular differentiation, DNA repair, autophagy, cell survival vs ...
Sailu Sarvagalla +2 more
exaly +3 more sources
Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer
Indian Journal of Pathology and Microbiology, 2021 Background: Yin Yang 1 (YY1), the multifunctional transcription factor, has recently been assigned biological properties related to human malignancies. YY1 can facilitate both tumor suppression and tumor growth.
Hyunsung Kim +7 more
doaj +1 more source
Multifaceted regulation of hepatic lipid metabolism by YY1
Life Science Alliance, 2021 This study shows that YY1 regulates hepatic lipid metabolism by directly or indirectly regulating the expression of several key upstream transcription factors and their coactivators.
Gang Pan +5 more
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YY1 Is Required for Germinal Center B Cell Development. [PDF]
PLoS ONE, 2016 YY1 has been implicated as a master regulator of germinal center B cell development as YY1 binding sites are frequently present in promoters of germinal center-expressed genes. YY1 is known to be important for other stages of B cell development including
Anupam Banerjee +6 more
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The role of transcription factor Yin Yang‐1 in colorectal cancer
Cancer Medicine, 2023 Background Yin Yang‐1 (YY1) is identified as a transcription factor with multiple functions. However, the role of YY1 in tumorigenesis remains controversial and its regulatory effects may depend upon not only cancer types, but also its interacting ...
Zhiying Shao +8 more
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YY1-binding sites provide central switch functions in the PARP-1 gene expression network.
PLoS ONE, 2012 Evidence is presented for the involvement of the interplay between transcription factor Yin Yang 1 (YY1) and poly(ADP-ribose) polymerase-1 (PARP-1) in the regulation of mouse PARP-1 gene (muPARP-1) promoter activity.
Martina Doetsch +4 more
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JCI Insight, 2021 Th17 cells are involved in rheumatoid arthritis (RA) pathogenesis. Our previous studies have revealed that transcription factor Yin Yang 1 (YY1) plays an important role in the pathogenic mechanisms of RA.
Jinpiao Lin +7 more
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Biomarker Research, 2018 Background Yin Yang 1 (YY1) is a transcription factor that plays an important role during all stages of B cell differentiation. Several studies reported upregulation of YY1 in B cell derived lymphoma, indicating that it might act as an oncogene ...
Jéssica Arribas Arranz +3 more
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The Protective Role of Yin‐Yang 1 in Cardiac Injury and Remodeling After Myocardial Infarction
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Exploring potential therapeutic target is of great significance for myocardial infarction (MI) and post‐MI heart failure. Transcription factor Yin‐Yang 1 (YY1) is an essential regulator of apoptosis and angiogenesis, but its role in MI is ...
Yu Huang +10 more
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