Results 41 to 50 of about 14,755 (179)

Yin Yang 1 promotes the neuroendocrine differentiation of prostate cancer cells via the non‐canonical WNT pathway (FYN/STAT3)

Clinical and Translational Medicine, 2023
Background A growing number of studies have shown that Yin Yang 1 (YY1) promotes the development of multiple tumours. The purpose of the current study was to determine the mechanism by which YY1 mediates neuroendocrine differentiation of prostate cancer (
Rui‐ji Liu, Zhi‐Peng Xu, Xiang Huang, Bin Xu, Ming Chen   +4 more
doaj   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2- and CDKN1A-interacting protein (BCCIP) in cells

Protein & Cell, 2016
The BCCIP (BRCA2- and CDKN1A-interacting protein) is an important cofactor for BRCA2 in tumor suppression. Although the low expression of BCCIP is observed in multiple clinically diagnosed primary tumor tissues such as ovarian cancer, renal cell ...
Jiaming Su, Yi Sui, Jian Ding, Fuqiang Li, Shuang Shen, Yang Yang, Zeming Lu, Fei Wang, Lingling Cao, Xiaoxia Liu, Jingji Jin, Yong Cai   +11 more
doaj   +1 more source

Yin Yang 1 promotes aggressive cell growth in high‐grade breast cancer by directly transactivating kinectin 1

MedComm, 2022
Invasive cancer growth and metastasis account for the poor prognosis of high‐grade breast cancer. Recently, we reported that kinectin 1 (KTN1), a member of the kinesin‐binding protein family, promotes cell invasion of triple‐negative breast cancer and ...
Lin Gao, Wenbin Zhou, Ni Xie, Junying Qiu, Jingyi Huang, Zhe Zhang, Malin Hong, Jinquan Xia, Jing Xu, Pan Zhao, Li Fu, Yuwei Luo, Jing Jiang, Hui Gong, Jigang Wang, Yong Dai, Dixian Luo, Chang Zou   +17 more
doaj   +1 more source

In vivo YY1 knockdown effects on genomic imprinting [PDF]

Human Molecular Genetics, 2007
The YY1 transcription factor is predicted to control several imprinted domains, including the Peg3, Gnas and Xist/Tsix regions. To test this possibility, we have used RNA interference strategies to generate transgenic mouse lines that express reduced levels of the cellular YY1 protein.
Joomyeong, Kim, Jeong Do, Kim
openaire   +2 more sources

CircRNA circYY1 (hsa_circ_0101187) Modulates Cell Glycolysis and Malignancy Through Regulating YY1 Expression by Sponging miR-769-3p in Breast Cancer

Cancer Management and Research, 2021
Xiaobin Zhang,1 Jiehua Li,1 Qin Feng2 1Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning City, People’s Republic of China; 2Department of Pathology, Peking University Cancer ...
Zhang X, Li J, Feng Q
doaj  

YY1 Promotes Telomerase Activity and Laryngeal Squamous Cell Carcinoma Progression Through Impairment of GAS5-Mediated p53 Stability

Frontiers in Oncology, 2021
Yin Yang 1 (YY1) is a key transcription factor that exerts functional roles in the cell biological process of various cancers. The current study aimed to elucidate the role and mechanism of YY1 in laryngeal squamous cell carcinoma (LSCC).
Xudong Wei, Xudong Wei, Xudong Wei, Fenglei Liu, Fenglei Liu, Xuelian Jiang, Xuelian Jiang, Xiaoyan Xu, Xiaoyan Xu, Tianhao Zhou, Tianhao Zhou, Chengfang Kang, Chengfang Kang   +12 more
doaj   +1 more source

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source

YY1-miR-146a-YY1 Regulatory Circuitry: A Potential Mechanism of Prostate Cancer Formation and Progression [PDF]

WIMJ Open, 2014
MicroRNA-146a (miR-146a) has been demonstrated as a tumour-suppressor in different malignancies including prostate cancer. As an endogenous small RNA, miR-146a regulates several gene expressions at the post-transcriptional level. Previous studies indicate that miR-146a is highly expressed in normal prostate tissue and significantly down-regulated in ...
B Xu, N Tong, S Chen, Y Yang, X Zhang, H Jiang, C Sun, N Liu, J Liu, G Sha, W Zhu, M Chen   +11 more
openaire   +1 more source

Bioinformatics Analysis of the Expression and Prognostic Significance of Transcription Factor YY1 in Gastric Cancer

Cancer Reports
Background Emerging evidence indicates that the transcription factor Yin Yang 1 (YY1) plays a critical role in the carcinogenesis and progression of various human malignancies.
Wenliang Chen, Huanhuan Wang, Ntiak Achi, Jinjin Hao, Rui Gong, Qiang Zhao   +5 more
doaj   +1 more source