Results 31 to 40 of about 14,755 (179)
Advanced Science, EarlyView.Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin +5 more
wiley +1 more source
BAP1 complexes with YY1 and RBBP7 and its downstream targets in ccRCC cells
Open Life SciencesClear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. A few genes, such as BAP1, are associated with the tumorigenesis of ccRCC. Mutations in BAP1 are related to a proportion of ccRCCs. In this study, to explore the functional
Wu Ying +3 more
doaj +1 more source
Yin Yang 1 Dynamically Regulates Antiviral Innate Immune Responses During Viral Infection
Cellular Physiology and Biochemistry, 2017 Background/Aims: Type I interferon (IFN-1) production and IFN-1 signaling play critical roles in the host antiviral innate immune responses. Although transcription factor Yin Yang 1 (YY1) has been reported to have a dual activator/repressor role during ...
Jie Zan +7 more
doaj +1 more source
Frontiers in Oncology, 2020 The discovery and description of the role of microRNAs has become very important, specifically due to their participation in the regulation of proteins and transcription factors involved in the development of cancer. microRNA-7 (miR-7) has been described
Mario Morales-Martinez +11 more
doaj +1 more source
Growth hormone promotes hepatic gluconeogenesis by enhancing BTG2–YY1 signaling pathway
Scientific Reports, 2021 Growth hormone (GH) is one of the critical factors in maintaining glucose metabolism. B-cell translocation gene 2 (BTG2) and yin yang 1 (YY1) are key regulators of diverse metabolic processes.
Jeong-Rang Jo +4 more
doaj +1 more source
YY1 complex in M2 macrophage promotes prostate cancer progression by upregulating IL-6
Journal for ImmunoTherapy of Cancer, 2023 Background Tumor-associated macrophages are mainly polarized into the M2 phenotype, remodeling the tumor microenvironment and promoting tumor progression by secreting various cytokines.Methods Tissue microarray consisting of prostate cancer (PCa), normal
Lihua Zhang +16 more
doaj +1 more source
Advanced Science, EarlyView.Poly(vinyl alcohol)‐modified liquid‐metal particles form conductive networks through spray‐induced self‐fusion without additional post‐treatment. Spray impact initiates oxide‐shell rupture and electrical contact, while subsequent Marangoni flow and capillary forces promote particle redistribution, neck growth, and network consolidation. This sequential
Keun‐Young Yook +13 more
wiley +1 more source
Regulation of PD-L1 Expression by YY1 in Cancer: Therapeutic Efficacy of Targeting YY1
CancersDuring the last decade, we have witnessed several milestones in the treatment of various resistant cancers including immunotherapeutic strategies that have proven to be superior to conventional treatment options, such as chemotherapy and radiation. This approach utilizes the host’s immune response, which is triggered by cancer cells expressing tumor ...
Ana Dillen +5 more
openaire +2 more sources
Cell Death and DiseaseYin Yang 1 (YY1) is a key transcription factor that has been implicated in the development of several malignancies. The stability of YY1 is regulated by the ubiquitin-proteasome system. The role of deubiquitinases (DUBs) and their impact on YY1 remain to
Liang Wu +8 more
doaj +1 more source
Yin Yang 1 expression predicts a favourable survival in diffuse large B-cell lymphoma
HeliyonAims: Yin Yang 1 (YY1) is a multifunctional transcription factor that plays an important role in tumour development and progression, while its clinical significance in diffuse large B-cell lymphoma (DLBCL) remains largely unexplored.
Tian Xue +8 more
doaj +1 more source