Results 21 to 30 of about 14,755 (179)
YY1 and CP2c in Unidirectional Spermatogenesis and Stemness
Development & Reproduction, 2020 Spermatogonial stem cells (SSCs) have stemness characteristics, including germ cell-specific imprints that allow them to form gametes. Spermatogenesis involves changes in gene expression such as a transition from expression of somatic to germ cell-specific genes, global repression of gene expression, meiotic sex chromosome inactivation, highly ...
Yong-Pil Cheon +3 more
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A YY1 Bridge for X Inactivation
Cell, 2011 Xist RNA inactivates one mammalian X chromosome (the Xi) by associating with it in cis. The mechanism of this interaction is unresolved. Jeon and Lee (2011) now show that YY1 binds both Xist RNA and DNA, thereby providing a mechanism to anchor Xist to the Xi and facilitate X chromosome inactivation.
Thorvaldsen, Joanne L. +2 more
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YY1AP, A Novel Co-activator of YY1 [PDF]
Journal of Biological Chemistry, 2004 With the aim of identifying potential cellular proteins that mediate the transcriptional regulation of YY1, a HeLa cDNA library was screened using the yeast two-hybrid system. A previously unknown protein interacting with YY1 was identified and named YY1AP.
Chen-Yu, Wang +5 more
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Disease Models & Mechanisms, 2020 Pleuropulmonary blastoma (PPB) is a very rare pediatric lung disease. It can progress from abnormal epithelial cysts to an aggressive sarcoma with poor survival.
Kim Landry-Truchon +8 more
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Stem Cell Reports, 2018 Summary: Yin Yang 1 (YY1) regulates early embryogenesis and adult tissue formation. However, the role of YY1 in stem cell regulation remains unclear. YY1 has a Polycomb group (PcG) protein-dependent role in mammalian cells.
Jia Wang +21 more
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International Journal of Genomics, 2022 Objective. To investigate the expression of Yin-Yang-1 (YY1) in esophageal carcinoma (ESCA) and its effect on glutamine metabolism in ESCA. Methods. The expression and roles of YY1 in ESCA were investigated using a series of bioinformatics databases and ...
Can Luo +8 more
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Molecular Brain, 2020 The highly conserved and ubiquitously expressed transcription factor Yin Yang 1 (Yy1), was named after its dual functions of both activating and repressing gene transcription.
Xiaonan Dong, Kin Ming Kwan
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Increased expression of PcG protein YY1 negatively regulates B cell development while allowing accumulation of myeloid cells and LT-HSC cells. [PDF]
PLoS ONE, 2012 Ying Yang 1 (YY1) is a multifunctional Polycomb Group (PcG) transcription factor that binds to multiple enhancer binding sites in the immunoglobulin (Ig) loci and plays vital roles in early B cell development.
Xuan Pan +7 more
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Expression levels of BAP1, OGT, and YY1 genes in patients with eyelid tumors
Türk Biyokimya Dergisi, 2021 The aim of this study was to investigate BAP1, OGT and YY1 genes and protein levels in 12 samples (8 males, 4 females) of eyelid tumor tissue with basal cell carcinoma (BCC) and 12 normal control subjects (8 males, 4 females).
Tas Ayca +4 more
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Molecular Therapy: Nucleic Acids, 2020 Transcription factor Yin Yang 1 (YY1) is upregulated in multiple tumors and plays essential roles in tumor proliferation and metastasis. However, the function of YY1 in breast cancer stemness remains unclear.
Qianqian Guo +7 more
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