Results 11 to 20 of about 14,755 (179)

Leishmania regulates host YY1: Comparative proteomic analysis identifies infection modulated YY1 dependent proteins.

PLoS ONE
The protein Yin-Yang 1 (YY1) is a ubiquitous multifunctional transcription factor. Interestingly, there are several cellular functions controlled by YY1 that could play a role in Leishmania pathogenesis.
Harsimran Kaur Brar, Eleanor Chen, Fabian Chang, Shawna Angel Lu, Dilraj Kaur Longowal, Kyung-Mee Moon, Leonard J Foster, Neil Reiner, Devki Nandan   +8 more
doaj   +3 more sources

Early-Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice. [PDF]

Adv Sci (Weinh)
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Chen K, He B, Liu K, Ma Z, Xu B.
europepmc   +2 more sources

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs. [PDF]

Adv Sci (Weinh)
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Lv Y, Wu F, Liang X, Liu C, Guo W, Zhang K, Niu J, Jiang W, Xu H, Jiang A, Zheng Y, Yu E, Wang X, Yan J, Xia J, Song C.   +15 more
europepmc   +2 more sources

Datasets of YY1 expression in rheumatoid arthritis patients

Data in Brief, 2016
The data presented in this article are related to the research article entitled “A critical role of transcription factor YY1 in rheumatoid arthritis by regulation of interleukin-6” (J. Lin, Y. He, J. Chen, Z. Zeng, B. Yang, Q. Ou, 2016) [1].
Jinpiao Lin, Yujue He, Junmin Chen, Zhiyong Zeng, Bin Yang, Qishui Ou   +5 more
doaj   +3 more sources

Wherefore Art Thou, YY1? [PDF]

Journal of Investigative Dermatology, 2011
In this issue, Taguchi et al. demonstrate that the transcription factor Yin Yang-1 (YY1) regulates proliferation in three-dimensional cultures of the HaCaT human keratinocyte cell line. HaCaT keratinocytes overexpressing YY1 form artificial epidermal constructs that are thicker than those produced from vector-transfected cells.
Bollag, Wendy B., Bollag, Roni J.
openaire   +2 more sources

Loss of Intestinal MSTN Promotes GLP‐1 Secretion Through SGLT1 Palmitoylation [PDF]

Advanced science
Intestinal MSTN deficiency enhances glucose‐stimulated GLP‐1 secretion and glucose tolerance in high‐fat diet‐fed mice. Mechanistically, loss of MSTN promotes YY1‐associated ZDHHC20 expression, increasing SGLT1 S‐palmitoylation at Cys301 and its plasma membrane localization in L cells.
Han S, Chang S, Luo Z, Sun K, Quan B, Lv Y, Li Z, Liu X, Lv S, Xuan M, Xu X, Fang X, Chang H, Zhang R, Yin X, Quan L, Kang J.   +16 more
europepmc   +2 more sources

Critical role of YY1 in cardiac morphogenesis [PDF]

Developmental Dynamics, 2015
AbstractBackground: Yin Yang 1 (YY1), the only DNA binding polycomb group protein, was reported to regulate cardiomyocyte differentiation during early cardiac mesoderm development. However, whether it contributes to cardiac morphogenesis at later developmental stage(s) during embryogenesis is unknown.Results: We excised YY1 in murine hearts during ...
Ilimbek, Beketaev, Yi, Zhang, Eun Young, Kim, Wei, Yu, Ling, Qian, Jun, Wang   +5 more
openaire   +2 more sources

Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1 [PDF]

Nature Communications, 2015
Little is known how lincRNAs are involved in skeletal myogenesis. Here we describe the discovery of Linc-YY1 from the promoter of the transcription factor (TF) Yin Yang 1 (YY1) gene. We demonstrate that Linc-YY1 is dynamically regulated during myogenesis in vitro and in vivo.
Liang Zhou, Kun Sun, Yu Zhao, Suyang Zhang, Xuecong Wang, Yuying Li, Leina Lu, Xiaona Chen, Fengyuan Chen, Xichen Bao, Xihua Zhu, Lijun Wang, Ling-Yin Tang, Miguel A. Esteban, Chi-Chiu Wang, Ralf Jauch, Hao Sun, Huating Wang   +17 more
openaire   +4 more sources

Multiple Mechanisms of Transcriptional Repression by YY1 [PDF]

Molecular and Cellular Biology, 1997
The four C-terminal GLI-Krüppel type zinc fingers of YY1 have been identified as a transcriptional repression domain. Previous reports have proposed DNA-bending and activator-quenching mechanisms for this zinc finger-mediated repression. In addition, previous work indicated that p300 and CBP might be involved in YY1-mediated repression.
K M, Galvin, Y, Shi
openaire   +2 more sources

The Yin and Yang of YY1 in the nervous system [PDF]

Journal of Neurochemistry, 2008
AbstractThe transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression depending on the cellular context. YY1 is ubiquitously expressed and highly conserved between species. However, its role varies in diverse cell types and includes proliferation, differentiation, and apoptosis.
Ye, He, Patrizia, Casaccia-Bonnefil
openaire   +2 more sources