Results 51 to 60 of about 14,755 (179)

Function of YY1 in Long-Distance DNA Interactions [PDF]

Frontiers in Immunology, 2014
During B cell development, long-distance DNA interactions are needed for V(D)J somatic rearrangement of the immunoglobulin (Ig) loci to produce functional Ig genes, and for class switch recombination (CSR) needed for antibody maturation. The tissue-specificity and developmental timing of these mechanisms is a subject of active investigation.
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YY1 Is a Positive Regulator of Transcription of theCol1a1 Gene [PDF]

Journal of Biological Chemistry, 2001
Both cell-specific and ubiquitous transcription factors in fibroblasts have been identified as critical for expression of the Col1a1 gene, which encodes the alpha1 chain of type I collagen. Here, we report that Yin Yang 1 (YY1) binds to the Col1a1 promoter immediately upstream of the TATA box, and we examine the functional implications of YY1 binding ...
F B, Riquet, L, Tan, B K, Choy, M, Osaki, G, Karsenty, T F, Osborne, P E, Auron, M B, Goldring   +7 more
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Cumulative Reproductive‐Lactation Burdens Induce a Systemic Immunometabolic Trade‐Off Between Milk Yield and Mammary Health of Dairy Cows

Animal Research and One Health, EarlyView.
A population‐scale longitudinal transcriptomic atlas reveals how lactation stage and parity reshape systemic gene regulation in dairy cows. Multiomics‐inspired analyses uncover dynamic immune and metabolic adaptations that contribute to reproductive longevity and sustained productivity across the bovine lifespan.
Yangyang Shen, Zhenjiang An, Yingying Jiang, Zijian Huang, Kunlin Chen, Yundong Gao, Jianbin Li, Shuwen Xia, Huili Wang   +8 more
wiley   +1 more source

Embryonic microenvironment suppresses YY1 and YY1-related genes in prostate cancer stem cells

Pathology - Research and Practice
Yin yang 1 (YY1), a transcription factor, plays crucial roles in cell fate specification, differentiation, and pluripotency during embryonic development. It is also involved in tumorigenesis, drug resistance, metastasis, and relapse caused by cancer stem cells (CSCs), particularly in prostate cancer (PCa).
Taşkıran, Ayşegül, Öktem, Gülperi, Demir, Aleyna, Oltulu, Fatih, Özçınar, Emine, Düzağaç, Fahriye, Güven, Ümmü, Karakoç, Emre, Çakır, Aslı, Ayla, Şule, Güven, Selçuk, Açıkgöz, Eda   +11 more
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Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

Functional interactions between YY1 and adenovirus E1A [PDF]

Nucleic Acids Research, 1995
YY1 is a C2H2-type zinc finger transcription factor that is a member of the human GLl-Kruppel family of proteins. YY1 represses transcription when bound upstream of transcription initiation sites. The repression can be relieved by adenovirus E1A and activation of target genes occurs. We have mapped the repression domain of YY1 to the C-terminal region,
J S, Lee, R H, See, K M, Galvin, J, Wang, Y, Shi   +4 more
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Modulation of ferroptosis via YY1-SLC7A11 axis in hepatic ischemia-reperfusion injury pathogenesis

Acta Biochimica et Biophysica Sinica
YY1 is a crucial transcription factor and plays significant roles in biological processes. However, the mechanisms of YY1 action in ischemia-reperfusion injury and its regulatory role in ferroptosis have not been extensively studied.
Wang Shaochuang, Jiang Baofei, Cao Jun, Xu Ting, Zhou Chengming, Yu Xiangyou, Wang Yi, Xie Yu, Ji Lindong, Zhou Guangrong, Wen Hao, Ma Long, Wu Kun   +12 more
doaj   +1 more source

The transcription factor YY1 is a novel substrate for Aurora B kinase at G2/M transition of the cell cycle. [PDF]

PLoS ONE, 2012
Yin Yang 1 (YY1) is a ubiquitously expressed and highly conserved multifunctional transcription factor that is involved in a variety of cellular processes. Many YY1-regulated genes have crucial roles in cell proliferation, differentiation, apoptosis, and
Ari Kassardjian, Raed Rizkallah, Sarah Riman, Samuel H Renfro, Karen E Alexander, Myra M Hurt   +5 more
doaj   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Crosstalk between YY1 and lncRNAs in cancer: A review

Medicine, 2022
Transcription factor YY1 is an important regulator of many pathways in tumor cell growth, prognosis, epithelial-mesenchymal transition, invasion, and resistance to chemotherapy. These effects lead to upregulation of YY1 associated with poor outcomes in many tumors.
Xiao-li Wang, Jing Li, Yan-hua Cao
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