Results 71 to 80 of about 14,755 (179)

Circulating microRNA signatures reveal core and reversible dysregulation in obesity via machine learning

The Journal of Physiology, EarlyView.
Abstract figure legend Machine learning analysis of circulating microRNA (miRNA) profiles identified a minimal set of biomarkers that distinguish individuals with obesity from lean individuals both before and after weight‐loss intervention. Comparative analyses revealed heterogeneous molecular responses to weight reduction, with some miRNAs showing ...
Yuan Yue, Rajesh Katare, Jeremiah Deng, Daniel Alencar Da Costa, Patrick Manning   +4 more
wiley   +1 more source

YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice

Nature Communications
Immune checkpoint therapy for prostate cancer (PCa), a classic ‘immune-cold’ tumor characterized by an immunosuppressive tumor microenvironment, failed previously in clinical trials, but the underlying causes remain elusive.
Wenchao Li, SaiSai Chen, Jian Lu, Weipu Mao, Shiya Zheng, Minhao Zhang, Tiange Wu, Yurui Chen, Kai Lu, Chunyan Chu, Chuanjun Shu, Yue Hou, Xue Yang, Naipeng Shi, Zhijun Chen, Lihua Zhang, Lei Zhang, Rong Na, Ming Chen, Shenghong Ju, Dingxiao Zhang, Yi Ma, Bin Xu   +22 more
doaj   +1 more source

Posttranslational Modification Cross‐Talk in Vascular Cells: Molecular Mechanisms and Therapeutic Implications for Atherosclerosis

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Atherosclerosis is driven by coordinated changes in endothelial cells (ECs), macrophages, and vascular smooth muscle cells (VSMCs). Post‐translational modifications (PTMs), phosphorylation, acetylation, ubiquitination, SUMOylation, O‐GlcNAcylation, palmitoylation, ISGylation, and ADP‐ribosylation, integrate metabolic, inflammatory, and ...
Weiwei Jiang, Haiping Du
wiley   +1 more source

A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1

Journal of Translational Medicine
Background N6-methyladenosine (m6A) modification is implicated in various diseases pathogenesis and physiological processes. We investigated the regulatory function of METTL3, a central m6A methyltransferase, in mediating m6A modification of YY1.
Weiqiang Xu, Junxuan Yi, Xinfeng Wei, Mingwei Wang, Mingqi Zhao, Mengdie Zhao, Xinyan Wang, Yannan Shen, Zhicheng Wang, Shunzi Jin   +9 more
doaj   +1 more source

MicroRNA-301a knockout attenuates peripheral nerve regeneration by delaying Wallerian degeneration

Neural Regeneration Research
Our recent study demonstrated that knockout of microRNA-301a attenuates migration and phagocytosis in macrophages. Considering that macrophages and Schwann cells synergistically clear the debris of degraded axons and myelin during Wallerian degeneration,
Lanya Fu, Xiaofang Hu, Jiawei Xu, Zhenlin Li, Jiale Cai, Xinrui Ma, Ying Zou, Ye He, Shuyi Xu, Yizhou Xu, Jiaqi Zhang, Yunlun Li, Jingmin Liu, Tsz Hei Fong, Xianghai Wang, Lixin Zhu, Dongfeng Chen, Aijun Liu, Xiaodong Ma, Jiasong Guo   +19 more
doaj   +1 more source

Single‐Cell Characterization of SPP1‐Expressing Macrophages and Their Predicted Interactions With T Cells in the Breast Cancer Bone Metastatic Microenvironment

Cancer Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background Breast cancer is a highly common malignancy in women, with bone as its most frequent site of distant metastasis significantly increasing mortality risk. Methods This study integrated single‐cell RNA sequencing datasets (GSE266330 and GSE243526) to systematically characterize the tumor microenvironment across normal tissue, primary ...
Zixue Xuan, Zhongxiu Wu, Yuting Zhong, Jinying Jiang, Yuan Zhang, Lei Cheng, Jun Zhang, Kai Wang   +7 more
wiley   +1 more source

Dissecting the Radioresponse Heterogeneity of Lung Adenocarcinoma Cells From the Perspective of Transcriptional and Regulatory Landscape

MedComm, Volume 7, Issue 11, November 2026.
Radiation‐associated transcriptional and regulatory cell states drive heterogeneous radioresponses in isogenic lung adenocarcinoma cells. ABSTRACT Radioresistance severely compromises radiotherapy efficacy for lung adenocarcinoma (LUAD), yet the intrinsic heterogeneity of cellular radioresponses among isogenic tumor cells remains poorly characterized ...
Huan Tao, Yaru Li, Leixin Ge, Lu Chen, Yang Zheng, Feiyue Ma, Changhui Ge, Hanjiang Fu, Yu Sun, Longteng Wang, Junting Wang, Xuemei Bai, Hao Li, Xiaochen Bo, Hebing Chen, Xiaofei Zheng   +15 more
wiley   +1 more source

Therapeutic Implications of Targeting YY1 in Glioblastoma

Cancers
The transcription factor Yin Yang 1 (YY1) plays a pivotal role in the pathogenesis of glioblastoma multiforme (GBM), an aggressive form of brain tumor. This review systematically explores the diverse roles of YY1 overexpression and activities in GBM, including its impact on the tumor microenvironment (TME) and immune evasion mechanisms. Due to the poor
Inesa Navasardyan, Apostolos Zaravinos, Benjamin Bonavida   +2 more
openaire   +2 more sources

Phosphorylation and the Transcription Factor YY1

The FASEB Journal, 2008
Yin‐Yang 1 (YY1) is a multifunctional transcription factor that is involved in the regulation of a large array of genes controlling cellular proliferation, differentiation and even apoptosis. Although our knowledge of the events regulated by YY1 has grown significantly over the past decade, we still know little of what regulates ...
raed Mtanis Rizkallah, Myra M Hurt
openaire   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source