Results 61 to 70 of about 14,755 (179)

Changes in gastrointestinal motility and gut hormone secretion after Roux‐en‐Y gastric bypass and sleeve gastrectomy for individuals with severe obesity

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Background Bariatric surgery is very effective in long‐term weight management. The present study was undertaken to investigate the short‐term effects of sleeve gastrectomy (SG) and of Roux‐en‐Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro‐cecal transit time and (b) secretion of regulatory gut ...
Jennifer A. Wilbrink, Mark van Avesaat, Simon W. Nienhuijs, Arnold Stronkhorst, Ad A. M. Masclee   +4 more
wiley   +1 more source

YY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box-mediated smooth muscle gene transcription during smooth muscle phenotypic modulation

Scientific Reports, 2020
Yin Yang 1 (YY1) regulates gene transcription in a variety of biological processes. In this study, we aim to determine the role of YY1 in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and in vitro.
Jian-Pu Zheng, Xiangqin He, Fang Liu, Shuping Yin, Shichao Wu, Maozhou Yang, Jiawei Zhao, Xiaohua Dai, Hong Jiang, Luyi Yu, Qin Yin, Donghong Ju, Claire Li, Leonard Lipovich, Youming Xie, Kezhong Zhang, Hui J. Li, Jiliang Zhou, Li Li   +18 more
doaj   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

YY1 Is a Structural Regulator of Enhancer-Promoter Loops [PDF]

Cell, 2017
There is considerable evidence that chromosome structure plays important roles in gene control, but we have limited understanding of the proteins that contribute to structural interactions between gene promoters and their enhancer elements. Large DNA loops that encompass genes and their regulatory elements depend on CTCF-CTCF interactions, but most ...
Sigova, Alla A., Hannett, Nancy M., Day, Daniel S., Abraham, Brian J., Cohen, Malkiel A., Nabet, Behnam, Buckley, Dennis L., Guo, Yang Eric, Hnisz, Denes, Bradner, James E., Gray, Nathanael S., Weintraub, Abraham Selby, Li, Charles Han, Zamudio Montes de Oca, Alicia, Jaenisch, Rudolf, Young, Richard A.   +15 more
openaire   +4 more sources

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis

Cell Death and Disease
Colorectal cancer (CRC) remains a significant global health issue with high incidence and mortality. Yin Yang 1 (YY1) is a powerful transcription factor that acts dual roles in gene activation and repression.
Zhi-Ying Shao, Wen-Dong Yang, Hui Qiu, Zhi-Hong He, Meng-Ru Lu, Qi Shen, Jin Ding, Jun-Nian Zheng, Jin Bai   +8 more
doaj   +1 more source

Role of the transcription factor yy1 in b cell non-hodgkin lymphoma development

Hematology Reports, 2020
Introduction Yin Yang 1 (YY1) is a transcription factor with a dual role in cancer. B-cell non-Hodgkin lymphomas (B-NHLs) are often characterized by the development of recurrence and/or resistance to therapy.
S. Vivarelli, L. Falzone, M. Libra
doaj  

Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1

Journal of Hematology & Oncology, 2021
The 3-hydroxyanthranilic acid (3-HAA), a derivative of kynurenine, was reported to suppress tumor growth. However, the function of 3-HAA largely remains unclear. Here, we report that 3-hydroxyanthranilic acid (3-HAA) is lower in tumor cells, while adding
Zhaopeng Shi, Guifang Gan, Xiang Xu, Jieying Zhang, Yuan Yuan, Bo Bi, Xianfu Gao, Pengfei Xu, Wenbin Zeng, Jixi Li, Youqiong Ye, Aiwu Zhou, Naixia Zhang, Wen Liu, Shuhai Lin, Jun Mi   +15 more
doaj   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Regulation of Transcription Factor YY1 by Acetylation and Deacetylation [PDF]

Molecular and Cellular Biology, 2001
YY1 is a sequence-specific DNA-binding transcription factor that has many important biological roles. It activates or represses many genes during cell growth and differentiation and is also required for the normal development of mammalian embryos. Previous studies have established that YY1 interacts with histone acetyltransferases p300 and CREB-binding
Y L, Yao, W M, Yang, E, Seto
openaire   +2 more sources