Results 81 to 90 of about 14,755 (179)

Genome Aging in Women: Hematopoietic Loss of X Chromosome as An Exemplar

Aging Cell, Volume 25, Issue 11, November 2026.
As studies at the intersection of genetics and aging are rapidly advancing, genome aging provides a novel mechanism by which aging phenotypes occur. In this Review, the authors examine the rise, expansion, and the consequences of X chromosome loss in female blood cells.
Xihan Guo, Xueqin Dai
wiley   +1 more source

The Role of Transcription Factor YY1 in the Biology of Cancer

Critical Reviews™ in Oncogenesis, 2017
The transcription factor Yin Yang 1 (YY1) is a ubiquitously expressed protein involved in several biological functions, including embryogenesis, differentiation, replication, and cellular proliferation. YY1 can both activate and repress transcription depending on its interactions with other transcription factors and co-factors.
Neeraj, Agarwal, Dan, Theodorescu
openaire   +3 more sources

Transcriptional dysregulation in neurodegenerative diseases: Who tipped the balance of Yin Yang 1 in the brain?

Neural Regeneration Research, 2019
Yin Yang 1 (YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types, including neurons. It controls neuronal differentiation, as well as neuronal specification and migration during the development of the ...
Zhefan Stephen Chen, Ho Yin Edwin Chan
doaj   +1 more source

Expression of Pax2 in the intermediate mesoderm is regulated by YY1

Developmental Biology, 2004
The transcription factor Pax2 is essential for the development of the urogenital system. Pax2 expression can be detected by mouse embryonic day 8.5 (E8.5) in the region of intermediate mesoderm fated to become the nephric duct, pronephros, and mesonephros.
Patel, Sanjeevkumar R, Dressler, Gregory R   +1 more
openaire   +2 more sources

Effect of YY1 on promoting breast cancer metastasis through EMT activation via the DUSP6/ERK signaling axis

徐州医科大学学报
Objective To investigate the role of YingYang1 (YY1) in breast cancer progression, particularly during metastasis, and explore the regulatory mechanism of YY1 on the downstream dual-specificity phosphatase 6 (DUSP6)/extracellular signal-regulated kinase (
HE Shiqing, HUANG Chuting, XU Jiahao, ZHANG Zeyu, ZHANG Jiaxin, LIU Zhao, ZHOU Xueyan   +6 more
doaj   +1 more source

The transcription factor YY1 is a substrate for Polo-like kinase 1 at the G2/M transition of the cell cycle.

PLoS ONE, 2011
Yin-Yang 1 (YY1) is an essential multifunctional zinc-finger protein. It has been shown over the past two decades to be a critical regulator of a vast array of biological processes, including development, cell proliferation and differentiation, DNA ...
Raed Rizkallah, Karen E Alexander, Ari Kassardjian, Bernhard Lüscher, Myra M Hurt   +4 more
doaj   +1 more source

YY1 mediates TGF-β1-induced EMT and pro-fibrogenesis in alveolar epithelial cells

Respiratory Research, 2019
Pulmonary fibrosis is a chronic, progressive lung disease associated with lung damage and scarring. The pathological mechanism causing pulmonary fibrosis remains unknown.
Chuyi Zhang, Xiaoping Zhu, Yifei Hua, Qian Zhao, Kaijing Wang, Lixiao Zhen, Guangxue Wang, Jinhui Lü, An Luo, William C. Cho, Xin Lin, Zuoren Yu   +11 more
doaj   +1 more source

YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes

Advanced Science
Activated microglia in the retina are essential for the development of autoimmune uveitis. Yin‐Yang 1 (YY1) is an important transcription factor that participates in multiple inflammatory and immune‐mediated diseases.
Jiaxing Huang, Xiaotang Wang, Na Li, Wei Fan, Xingran Li, Qian Zhou, Jiangyi Liu, Wanqian Li, Zhi Zhang, Xiaoyan Liu, Shuhao Zeng, Hui Yang, Meng Tian, Peizeng Yang, Shengping Hou   +14 more
doaj   +1 more source

YY1 Promotes Endothelial Cell-Dependent Tumor Angiogenesis in Hepatocellular Carcinoma by Transcriptionally Activating VEGFA

Frontiers in Oncology, 2019
Hepatocellular carcinoma (HCC) is a typical hypervascular solid tumor that requires neoangiogenesis for growth. The vascular endothelial growth factor (VEGF) is the most potent proangiogenic factor in neovascularization.
Wendong Yang, Zhongwei Li, Zhongwei Li, Rong Qin, Rong Qin, Xiaorui Wang, Huihui An, Huihui An, Yule Wang, Yule Wang, Yan Zhu, Yan Zhu, Yantao Liu, Yantao Liu, Shijiao Cai, Shuang Chen, Tao Sun, Tao Sun, Jing Meng, Jing Meng, Cheng Yang, Cheng Yang   +21 more
doaj   +1 more source

CENPA Promotes Endometrial Cancer Progression by Stabilizing YY1 and Enhancing Glycolytic Metabolism

Frontiers in Bioscience-Landmark
Background: Centromere protein A (CENPA) is a histone H3 variant essential for centromere function and has been implicated in tumorigenesis in several cancers.
Liqun Wang, Huaying Wu, Xiaohan Tang, Xiushuang Zheng, Lin Zhou, Meisong Lu   +5 more
doaj   +1 more source