Results 41 to 50 of about 13,919 (205)
BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF‐BP1
FEBS Open Bio, 2021 More than 40 000 patients worldwide die from esophageal cancer annually. The 5‐year survival rate of patients is only ~ 15–20%, and thus, there is an ongoing need to improve diagnosis and treatment of esophageal cancer.
Fengyun Wang +3 more
doaj +1 more source
Expression levels of BAP1, OGT, and YY1 genes in patients with eyelid tumors
Türk Biyokimya Dergisi, 2021 The aim of this study was to investigate BAP1, OGT and YY1 genes and protein levels in 12 samples (8 males, 4 females) of eyelid tumor tissue with basal cell carcinoma (BCC) and 12 normal control subjects (8 males, 4 females).
Tas Ayca +4 more
doaj +1 more source
BAP1: role in carcinogenesis and clinical implications
Translational Lung Cancer Research, 2020 BRCA-1 associated protein 1 (BAP1) is a tumor suppressor gene that has been implicated in the pathogenesis of several malignancies and is gaining more recognition as a crucial gene that could be amenable to therapeutic manipulation. There is a growing interest in prevention and establishing cancer screening guidelines in patients with germline BAP1 ...
Kobrinski, Daniel A. +2 more
openaire +3 more sources
A common ancestry for BAP1 and Uch37 regulators [PDF]
Bioinformatics, 2012 Abstract Summary: To reveal how the polycomb repressive–deubiquitinase (PR–DUB) complex controls substrate selection specificity, we undertook a detailed computational sequence analysis of its components: additional sex combs like 1 (ASXL1) and BRCA1-associated protein 1 (BAP1) proteins.
Luis Sánchez-Pulido +2 more
openaire +3 more sources
BAP1 in lung adenocarcinoma and thyroid
, 2018 BAP1 mutations influence the development of multiple tumors and are associated with poor prognosis. Its germline mutations are associated with hereditary cancer known as BAP1-tumor predisposing syndrome.
Farid, R (via Mendeley Data) +1 more
core +1 more source
BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers [PDF]
, 2019 The BAP1 tumor suppressor is mutated in many human cancers such as uveal melanoma, leading to poor patient outcome. It remains unclear how BAP1 functions in normal biology or how its loss promotes cancer progression.
Durante, Michael A. +15 more
core +1 more source
BAP1 Regulates the Hair Cycle through the TGFβ Signaling Pathway [PDF]
, 2023 As a skin appendage organ, the hair follicle provides an excellent paradigm to study tissue homeostasis as adult hair follicles continuously undergo cycles of growth (anagen), regression (catagen), and rest (telogen). BRCA-associated protein 1 (BAP1) is
King, Sarah Ann Souljah
core +1 more source
Cell Death and DiseaseGermline mutations of the deubiquitinase BRCA1-associated protein 1 (BAP1) lead to the “BAP1 cancer syndrome” characterized by development of cancers. However, the role of BAP1 in hepatocellular carcinoma (HCC) is unclear.
Xiaoyu Xie +12 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Advanced Science, EarlyView.Plant‐based nanomaterials derived from alfalfa serve as dual‐function catalysts, coupling photodegradation and phytoremediation to degrade polyethylene under UV‐A light and in soil. The nanomaterials work synergistically with alfalfa and soil microbes, achieving efficient plastic breakdown without trophic transfer.
Haoran Liu +4 more
wiley +1 more source