Results 21 to 30 of about 13,919 (205)

BAP1 is required prenatally for differentiation and maintenance of postnatal murine enteric nervous system

The Journal of Clinical Investigation
Epigenetic regulatory mechanisms are underappreciated, yet are critical for enteric nervous system (ENS) development and maintenance. We discovered that fetal loss of the epigenetic regulator Bap1 in the ENS lineage caused severe postnatal bowel ...
Sabine Schneider, Jessica B. Anderson, Rebecca P. Bradley, Katherine Beigel, Christina M. Wright, Beth A. Maguire, Guang Yan, Deanne M. Taylor, J. William Harbour, Robert O. Heuckeroth   +9 more
doaj   +2 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

BAP1 germline variants in Finnish patients with malignant mesothelioma [PDF]

, 2022
Objectives: Although asbestos exposure is the most common cause of malignant mesothelioma (MM), an aggressive cancer of the pleura or peritoneum, up to 7% of patients harbor a genetic predisposition to MM.
Turunen, Joni A., Repo, Pauliina, Sutinen, Eva, Staskiewicz, Aleksandra, Rönty, Mikko, Kivelä, Tero T., Myllärniemi, Marjukka, Aleksandra Staskiewicz, Eva Sutinen, null Tero T. Kivelä, Mikko Rönty, Marjukka Myllärniemi, Pauliina Repo, Joni A. Turunen   +13 more
core   +1 more source

Targeting BAP1 with small compound inhibitor for colon cancer treatment

Scientific Reports, 2023
BRCA1-associated protein-1 (BAP1) is a ubiquitin C-terminal hydrolase domain-containing deubiquitinase. The gene encoding BAP1 is mutated in various human cancers, including mesothelioma, uveal melanoma and renal cell carcinoma.
Minhwa Kang, Seul Gi Park, Shin-Ai Lee, Soyi Kim, Daye Lee, Mukesh Eknath Shirbhate, So-Yeon Youn, Kwan Mook Kim, Sun-Shin Cha, Jongbum Kwon   +9 more
doaj   +1 more source

BAP1 as a guardian of genome stability: implications in human cancer

Experimental and Molecular Medicine, 2023
BAP1 is a ubiquitin C-terminal hydrolase domain-containing deubiquitinase with a wide array of biological activities. Studies in which advanced sequencing technologies were used have uncovered a link between BAP1 and human cancer.
Jongbum Kwon, Daye Lee, Shin-Ai Lee
doaj   +1 more source

GFP-BAP1 proteomics show established BAP1 biology and validate HAT1 as a BAP1 interacting protein.

, 2021
(A and B). Volcanoplots showing GFP-BAP1 interaction partners for cytoplasmic (A) and nuclear fractions (B). (C). GFP-fusion constructs were expressed in HeLa cells and lysates were used in GFP immunoprecipitation.
Roy Baas (436006), Fenna J. van der Wal (11506706), Haico van Attikum (255451), Titia K. Sixma (157504), Onno B. Bleijerveld (2029171)   +4 more
core   +1 more source

CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma

Cell Death Discovery, 2023
Malignant mesothelioma (MMe) is a rare but aggressive malignancy. Although the molecular genetics of MMe is known, including BRCA1-associated protein-1 (BAP1) gene alterations, the prognosis of MMe patients remains poor. Here, we generated BAP1 knockout (
Sivasundaram Karnan, Akinobu Ota, Hideki Murakami, Md. Lutfur Rahman, Md Wahiduzzaman, Muhammad Nazmul Hasan, Lam Quang Vu, Ichiro Hanamura, Akihito Inoko, Miho Riku, Hideaki Ito, Yoshifumi Kaneko, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa   +15 more
doaj   +1 more source

Loss of BAP1 expression is associated with genetic mutation and can predict outcomes in gallbladder cancer. [PDF]

PLoS ONE, 2018
BACKGROUND:BRCA-1 associated protein (BAP1) is a de-ubiquitinating enzyme that regulates gene expression. Recently, the BAP1 mutation and its involvement in cancer survival have been reported in a range of tumor types, including uveal melanoma ...
Takashi Hirosawa, Masaharu Ishida, Kentaro Ishii, Keigo Kanehara, Katsuyoshi Kudo, Shinobu Ohnuma, Takashi Kamei, Fuyuhiko Motoi, Takeshi Naitoh, Florin M Selaru, Michiaki Unno   +10 more
doaj   +1 more source

Loss of Nuclear BAP1 Expression Is Associated with High WHO/ISUP Grade in Clear Cell Renal Cell Carcinoma [PDF]

Journal of Pathology and Translational Medicine, 2018
Background BRCA1-associated protein 1 (BAP1) mutations are frequently reported in clear cell renal cell carcinoma (ccRCC); however, very few studies have evaluated the role of these mutations in other renal cell carcinoma (RCC) subtypes.
Young Chan Wi, Ahrim Moon, Min Jung Jung, Yeseul Kim, Seong Sik Bang, Kiseok Jang, Seung Sam Paik, Su-Jin Shin   +7 more
doaj   +1 more source

BAP1 and cancer

Nature Reviews Cancer, 2013
BAP1 is a deubiquitylase that is found associated with multiprotein complexes that regulate key cellular pathways, including the cell cycle, cellular differentiation, cell death, gluconeogenesis and the DNA damage response (DDR). Recent findings indicate that germline BAP1 mutations cause a novel cancer syndrome that is characterized, at least in the ...
Michele, Carbone, Haining, Yang, Harvey I, Pass, Thomas, Krausz, Joseph R, Testa, Giovanni, Gaudino   +5 more
openaire   +3 more sources