Results 31 to 40 of about 13,919 (205)

Elucidating BAP1-microRNA regulatory networks in mesothelioma [PDF]

, 2018
BRCA-1 Associated Protein 1 (BAP1) is a nuclear deubiquitylase (DUB) frequently inactivated by mutation in specific cancers including malignant pleural mesothelioma (MPM).
Butt, Z
core   +1 more source

Loss of BAP1 Expression in Basal Cell Carcinomas in Patients With Germline BAP1 Mutations [PDF]

American Journal of Clinical Pathology, 2015
Patients with heterozygous germline mutations in BRCA1-associated protein 1 (BAP1), a tumor suppressor gene, develop a tumor predisposition syndrome (OMIM 614327) with increased risk of uveal and cutaneous melanomas, cutaneous atypical and epithelioid melanocytic lesions, lung adenocarcinoma, clear cell renal cell carcinoma, and other tumors.
Mark C, Mochel, Adriano, Piris, Vania, Nose, Mai P, Hoang   +3 more
openaire   +2 more sources

Transposase mapping identifies the genomic targets of BAP1 in uveal melanoma

BMC Medical Genomics, 2018
Background BAP1 is a histone deubiquitinase that acts as a tumor and metastasis suppressor associated with disease progression in human cancer. We have used the “Calling Card System” of transposase-directed transposon insertion mapping to identify the ...
Matthew Yen, Zongtai Qi, Xuhua Chen, John A. Cooper, Robi D. Mitra, Michael D. Onken   +5 more
doaj   +1 more source

BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN

Molecular Oncology, 2021
Deubiquitinase BAP1 is an important tumor suppressor in several malignancies, but its functions and critical substrates in prostate cancer (PCa) remain unclear.
Rong Deng, Yanmin Guo, Lian Li, Jianfeng He, Zhe Qiang, Hailong Zhang, Ran Chen, Yanli Wang, Xian Zhao, Jianxiu Yu   +9 more
doaj   +1 more source

Integrated analysis of anti-tumor roles of BAP1 in osteosarcoma

Frontiers in Oncology, 2022
BackgroundThis study aims to screen out differentially expressed genes (DEGs) regulated by BRCA1-associated protein 1 (BAP1) in osteosarcoma cells, and to analyze their biological functions.MethodsThe microarray dataset GSE23035 of BAP1-knockdown ...
Dong Hu, Yongbin Zheng, Yongbin Zheng, Yongbin Zheng, Yongbin Zheng, Xuehai Ou, Lijun Zhang, Xiaolong Du, Shaoyan Shi   +8 more
doaj   +1 more source

Can BAP1 expression loss in mesothelial cells be an indicator of malignancy? [PDF]

Journal of Pathology and Translational Medicine, 2020
Background Malignant mesothelioma is a highly aggressive tumor that can be confused with a benign mesothelial lesion, especially cytomorphologic lesions. BRCA1-associated protein 1 (BAP1) acts as a tumor suppressor.
Hanife Gulnihal Ozdemir, Sermin Coban Kokten, Nagehan Ozdemir Barisik   +2 more
doaj   +1 more source

Expression of BRCA1-associated protein 1 in primary tumors and metastasis in an animal model of uveal melanoma

The Pan-American Journal of Ophthalmology, 2020
Background: Uveal melanoma (UM) is the most common primary intraocular tumor in adults. Despite successful local treatment, approximately 50% of these patients develop lethal metastatic disease.
Clara E Castro, Julia Valdemarin Burnier, Sabrina Bergeron, Jacqueline Coblentz, Ana Beatriz Dias, Miguel Noel Burnier   +5 more
doaj   +1 more source

Calpastatin participates in the regulation of cell migration in BAP1-deficient uveal melanoma cells [PDF]

International Journal of Ophthalmology, 2019
AIM: To detect how BRCA-associated protein 1 (BAP1) regulates cell migration in uveal melanoma (UM) cells. METHODS: Wound healing and transwell assays were performed to detect UM cell migration abilities.
Han Yue, Feng-Xi Meng, Jiang Qian, Bin-Bin Xu, Gang Li, Ji-Hong Wu   +5 more
doaj   +1 more source

Prognostic Value of BAP1 and Preferentially Expressed Antigen in Melanoma (PRAME) Immunohistochemistry in Uveal Melanomas [PDF]

, 2023
Uveal melanoma (UM) is the most common primary intraocular tumor in adults, and despite excellent local control, more than 50% of patients develop and die from metastatic disease.
Seider, Michael I, Bloomer, Michele M, Uludag, Gunay, Pekmezci, Melike, Lee, Kar Wan, Afshar, Armin R, Han, Lucy M, Gunay Uludag, Lucy M. Han, Armin R. Afshar, Michael I. Seider, Michele M. Bloomer, Kar Wan Lee, Melike Pekmezci   +13 more
core   +1 more source

Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas [PDF]

, 2017
BackgroundPatients with meningiomas have widely divergent clinical courses. Some entirely recover following surgery alone, while others have relentless tumor recurrences.
van Hummelen, Paul, Barker, Frederick G, Abedalthagafi, Malak, Ligon, Keith L, Nayyar, Naema, Vaubel, Rachael A, Santagata, Sandro, Wen, Patrick Y, Dunn, Ian F, Bi, Wenya Linda, Giannini, Caterina, Curry, William T, Cahill, Daniel P, Louis, David N, Alexander, Brian M, Batchelor, Tracy T, Perry, Arie, Al-Mefty, Ossama, Gill, Corey M, Shankar, Ganesh M, Carter, Scott L, Agarwalla, Pankaj K, Reardon, David A, Beroukhim, Rameen, Thorner, Aaron R, Brastianos, Priscilla K, Merrill, Parker H, Brewster, Ryan, Meyerson, Matthew, Ligon, Azra H   +29 more
core   +2 more sources