Results 51 to 60 of about 13,919 (205)

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

, 2019
International audienceIn Drosophila, a complex consisting of Calypso and ASX catalyzes H2A deubiquitination and has been reported to act as part of the Polycomb machinery in transcriptional silencing.
Postel-Vinay, S., Vassilev, I., Margueron, R., Chen, Hong, Dingli, Florent, Pasmant, Eric, Servant, N., Pasmant, E., Vassilev, Ivaylo, Michaud, Audrey,, Margueron, Raphael, Campagne, Antoine, Loew, D., Campagne, A., Lee, M.K., Loew, Damarys, Wassef, Michel, M., Postel-Vinay, Sophie, Wassef, Michel,, Zielinski, D., Le Corre, S., Wassef, M., Michaud, A., Shahidian, Lara, Z, Shahidian, Lara,, Dingli, F., Le Corre, Stéphanie, Michaud, Audrey, A., Servant, Nicolas, Chen, H., Lee, Ming-Kang, Zielinski, Dina, Shahidian, L.Z.   +32 more
core   +1 more source

BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion

eLife, 2021
Normal function of the placenta depends on the earliest developmental stages when trophoblast cells differentiate and invade into the endometrium to establish the definitive maternal-fetal interface.
Vicente Perez-Garcia, Georgia Lea, Pablo Lopez-Jimenez, Hanneke Okkenhaug, Graham J Burton, Ashley Moffett, Margherita Y Turco, Myriam Hemberger   +7 more
doaj   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation

Genetics and Molecular Biology
BRCA1-associated protein 1 (BAP1) is a deubiquitinating enzyme that has long been considered to be a tumor suppressor in various tumors, including renal cell carcinoma, uveal melanoma, mesothelioma, and cutaneous melanoma.
Chan Mi Park, Jae Eun Lee, Jung Hwa Kim
doaj   +1 more source

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

Nature Communications, 2018
Additional sex combs-like (ASXLs) stimulate BAP1 deubiquitinase activity to induce tumor suppression, but how these complexes work in coordination in vivo is unclear.
Salima Daou, Haithem Barbour, Oumaima Ahmed, Louis Masclef, Caroline Baril, Nadine Sen Nkwe, Daméhan Tchelougou, Maxime Uriarte, Eric Bonneil, Derek Ceccarelli, Nazar Mashtalir, Mika Tanji, Jean-Yves Masson, Pierre Thibault, Frank Sicheri, Haining Yang, Michele Carbone, Marc Therrien, El Bachir Affar   +18 more
doaj   +1 more source

BAP1 Downregulates NRF2 Target Genes and Exerts Anti-Tumorigenic Effects by Deubiquitinating KEAP1 in Lung Adenocarcinoma

Antioxidants, 2022
KELCH-ECH-associated protein 1 (KEAP1) is an adaptor protein of Cullin 3 (CUL3) E3 ubiquitin ligase that targets a redox sensitive transcription factor, NF-E2-related factor 2 (NRF2).
Jong-Su Kang, Le Ba Nam, Ok-Kyung Yoo, Kyeong Lee, Young-Ah Suh, Dalyong Kim, Woo Kyung Kim, Chi-Yeon Lim, Haeseung Lee, Young-Sam Keum   +9 more
doaj   +1 more source

Impact of Molecular Alterations on Survival in Biliary Tract Cancers: A Retrospective Belgian Cohort Study

International Journal of Cancer, EarlyView.
ABSTRACT Biliary tract cancers (BTCs) are aggressive malignancies associated with a poor prognosis. Although molecular profiling is recommended to guide therapeutic decision‐making, real‐practice data on the prevalence and prognostic significance of genomic alterations in European BTC cohorts remain limited.
Jorine Arnouts, Léon C. van Kempen, Senada Koljenović, Helena Oliveres, Pieterjan Vanclooster, Hans Prenen, Caro De Weerdt, Siddharth Chhajlani, Geert Roeyen, Laure Sorber, Koen De Winne, Jonas Dahnoun, Greetje Vanhoutte, Timon Vandamme, Karen Zwaenepoel   +14 more
wiley   +1 more source

Germline BAP1 mutations induce a Warburg effect

, 2017
Carriers of heterozygous germline BAP1 mutations (BAP1(+/-)) develop cancer. We studied plasma from 16 (BAP1(+/-)) individuals from 2 families carrying different germline BAP1 mutations and 30 BAP1 wild-type (BAP1(WT)) controls from these same families ...
Giorgi, Carlotta, Pellegrini, Laura, Xie, Guoxiang, Haining Yang, Mingming Su, Morris, Paul, Pinton, Paolo, Andrea Napolitano, Su, Mingming, Carbone, Michele, Simone Patergnani, Shafi Kuchay, Michele Carbone, Greg Sakamoto, Valentina Signorato, Wei Jia, Pass, Harvey I., Angela Bononi, Sandra Pastorino, Harvey I Pass, Laura Pellegrini, Guoxiang Xie, Jia, Wei, Patergnani, Simone, Paul Morris, Gaudino, Giovanni, Carlotta Giorgi, Giovanni Gaudino, Kuchay, Shafi, Paolo Pinton, Yang, Haining, Pastorino, Sandra, Signorato, Valentina, Bononi, Angela, Sakamoto, Greg, Napolitano, Andrea   +35 more
core   +1 more source

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source

BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs

Journal of Translational Medicine, 2012
Background BRCA1–associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21. Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocytic tumors and other neoplasms ...
Carbone Michele, Ferris Laura, Baumann Francine, Napolitano Andrea, Lum Christopher A, Flores Erin G, Gaudino Giovanni, Powers Amy, Bryant-Greenwood Peter, Krausz Thomas, Hyjek Elizabeth, Tate Rachael, Friedberg Joseph, Weigel Tracey, Pass Harvey I, Yang Haining   +15 more
doaj   +1 more source