Results 51 to 60 of about 81,608 (302)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Prismatic to asbestiform offretite from Northern Italy. Occurrence, morphology and crystal-chemistry of a new potentially hazardous zeolite [PDF]

, 2018
A multi-methodological approach, based upon field investigation, morphological characterization, chemical analysis and structure refinement was applied to different samples of fibrous offretite, a new potentially hazardous zeolite recently discovered in ...
Arcangeli, Pierluca, Ballirano, Paolo, Boscardin, Matteo, Giordani, Matteo, Mattioli, Michele, Pacella, Alessandro, Valentini, Laura   +6 more
core   +3 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Mesothelioma of tunica vaginalis of "uncertain malignant potential" - an evolving concept: case report and review of the literature

Diagnostic Pathology, 2011
Mesothelioma of tunica vaginalis is a rare neoplasm, typically demonstrating frankly malignant morphology and aggressive behavior. Rare cases of well-differentiated papillary mesotheliomas have also been reported, which, in contrast, demonstrate indolent
Yilmaz Asli, Kulaga Andrew, Barr Richard, Trpkov Kiril   +3 more
doaj   +1 more source

Anti-Tumor Effects of TRAIL-Expressing Mesenchymal Stromal Cells in a Mouse Xenograft Model of Human Mesothelioma [PDF]

, 2015
Malignant mesothelioma (MM) remains a highly deadly malignancy with poor treatment option. The MM cells further promote a highly inflammatory microenvironment which contributes to tumor initiation, development, severity, and propagation. We reasoned that
Janes, SM, Sage, E
core  

The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. [PDF]

, 2011
BackgroundTumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates. Tumor microenvironments, however, are difficult to study in vitro.
Broaddus, V Courtney, Feng, Mingqian, Fitzgerald, David, Hassan, Raffit, Ho, Mitchell, Nagashima, Kunio, Phung, Yen, Xiang, Xinran, Zhang, Jingli   +8 more
core   +3 more sources

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Post-irradiation pericardial malignant mesothelioma with deletion of p16: a case report

Cancer Biology & Medicine, 2018
Malignant mesotheliomas are rather uncommon neoplasms associated primarily with asbestos exposure; however, they may also arise as second primary malignancies after radiation therapy, with a latency period of 15–25 years.
Yalda B. Naeini, Ramir Arcega, Sharon Hirschowitz, Nagesh Rao, Haodong Xu   +4 more
doaj   +1 more source

Is Adenosine Deaminase in Pleural Fluid a Useful Marker for Differentiating Tuberculosis from Lung Cancer or Mesothelioma in Japan, a Country with Intermediate Incidence of Tuberculosis? [PDF]

, 2011
The objective of this study was to evaluate the utility of the determination of adenosine deaminase (ADA) level in pleural fluid for the differential diagnosis between tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) in Japan, a ...
Aoe, Keisuke, Chikamori, Kenichi, Hiraki, Akio, Kishino, Daizo, Kiura, Katsuyuki, Maeda, Tadashi, Murakami, Kazuo, Ogata, Yoshiko, Tanimoto, Mitsune, Ueoka, Hiroshi   +9 more
core   +1 more source

Malignant pericardial mesothelioma [PDF]

European Journal of Cardio-Thoracic Surgery, 2011
A 72-year-old female, who had no asbestos exposure, felt chest pain. She was diagnosed with pericarditis. After 6 months, a follow-up chest computed tomography (CT) showed a thickened pericardium (Fig. 1(A) and (B)) and a positron emission tomography (PET) scan was positive along the pericardium (Fig. 1(C)).
Motoki, Sakuraba, Takahiro, Tatsumori, Michihiro, Hirama, Kanako, Ogura   +3 more
openaire   +2 more sources