Results 61 to 70 of about 81,608 (302)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Risk factors, prognostic factors, and nomograms for distant metastasis in patients with malignant pleural mesothelioma: A population-based retrospective study

Journal of International Medical Research
Objectives Malignant pleural mesothelioma is a rare and aggressive thoracic tumor with a poor prognosis, wherein distant metastasis is associated with the lowest survival rates.
Quzhe Lu, Chao Liu, Meixiang Xu, Zhi Hu, Hui Yin, Jie Yang   +5 more
doaj   +1 more source

Malignant mesothelioma associated with localized myocardial fibrosis: a case report

BMC Cardiovascular Disorders, 2021
Left ventricular dysfunction is a common reason for patients’ referral to cardiology departments for examination. Cardiac involvement is one of the possible yet rare presentations of malignant mesothelioma.
Kristyna Vymetalova, Pavol Tomasov, Rostislav Polasek   +2 more
doaj   +1 more source

Second line therapy in malignant pleural mesothelioma: a systematic review [PDF]

, 2015
After the implementation of standard first line chemotherapy with platinum and antifolates in pleural mesothelioma, patients are confronted with a need for second line treatment at relapse or progression.
Baas, Paul, Buikhuisen, Wieneke A, Hiddingab, Birgitta I, Van Meerbeeck, Jan   +3 more
core   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Role of interleukin-6 (IL-6) in diagnosis of malignant pleural mesothelioma

Egyptian Journal of Chest Disease and Tuberculosis, 2015
Aim of the work: To evaluate the role of interleukin-6 (IL-6) in diagnosis of malignant pleural mesothelioma by detecting its level in the pleural fluid and serum of the patient with malignant pleural mesothelioma in comparison with other causes of ...
Rehab El Sayed, Ali Okab, Momamed El-Mahdy, Ibrahim Kasb, Yaser Ismail   +4 more
doaj   +1 more source

The role of peroxiredoxins in cancer [PDF]

, 2017
Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22-27 kDa) non-seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides and peroxynitrite.
CAPALBO, CARLO, COPPA, Anna, D'INZEO, SONIA, GIANNINI, Giuseppe, NICOLUSSI, Arianna   +4 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Peritoneal malignant mesothelioma with epithelioid type, demonstrating high serum and ascitic KL-6 levels: immunohistochemical analyses

Rare Tumors, 2015
We report a case of KL-6 producing peritoneal malignant mesothelioma. A 56-year-old woman was referred to our hospital on November 2005 with severe abdominal distention.
Saifun Nahar, Manabu Nakamoto, Akira Hokama, Chiharu Kobashigawa, Masatoshi Kaida, Tetsu Kinjo, Tetsuo Hirata, Nagisa Kinjo, Masanao Saio, Naoki Yoshimi, Yuji Ohtsuki, Jiro Fujita   +11 more
doaj   +1 more source

Tsc1-Tp53 loss induces mesothelioma in mice, and evidence for this mechanism in human mesothelioma [PDF]

, 2015
Mesothelioma is diagnosed in approximately 2,500 patients in the United States every year, most often arising in the pleural space, but also occurring as primary peritoneal mesothelioma.
Bueno, Raphael, Chirieac, Lucian R., Guo, Yanan, Kwiatkowski, David J., Malinowska, Izabela A., Pass, Harvey, Wu, Wenhao   +6 more
core   +1 more source