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Neurofibromatosis 1 is a relatively rare genetic disease characterized by widespread neurofibromas originating from the peripheral nervous system. Most growths are benign, but some carry a risk of transformation to malignant peripheral nerve sheath ...
Austin G. Kazarian +4 more
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Update on Peripheral Nervous System Tumors: Lesions with Epithelioid and Melanotic Features
While the majority of peripheral nerve sheath tumors (PNSTs) are histomorphologically composed of non-pigmented and slender spindle cells, unusual PNST lesions can present as epithelioid or pigmented cell tumors, a reflection of the inherent plasticity ...
Carlos N. Prieto Granada
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Background Malignant peripheral nerve sheath tumors are rare tumor entities that originate from peripheral nerve sheaths and have an unfavorable prognosis. Metastatic spread to the cerebral parenchyma is absolutely rare.
Lutterbach Johannes +4 more
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Malignant peripheral nerve sheath tumor: Rare tumor, rarer presentation
A 57-year-old male presented with a fleshy mass encroaching on the limbus in the right eye. With a clinical diagnosis of invasive squamous neoplasia, topical interferon-alpha was started.
Kamalpreet Likhari
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Clinical course of a malignant peripheral nerve sheath tumor in a Siberian tiger (Panthera tigris altaica) [PDF]
A 14-year-old male Siberian tiger (Panthera tigris altaica) was admitted with an ulcerating mass on the right thoracic wall. Radiographic and computed tomographic evaluation indicated 2 isolated cutaneous masses without any signs of metastasis. Histology
Rütten, Maja +23 more
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For resectable malignant peripheral nerve sheath tumors, the additional benefits of radiotherapy remain controversial. This study aims to investigate whether there is an additional benefit of radiotherapy for resectable malignant peripheral nerve sheath ...
Yiding XIAO +3 more
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Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source
Malignant peripheral nerve sheath tumor of the cervical vagus nerve in a neurofibromatosis type 1 patient - An unusual presentation [PDF]
Malignant peripheral nerve sheath tumors (MPNST’S) of the head and neck comprise 2% to 6% of head and neck sarcomas. These tumors may arise as sporadic variants or in patients with neurofibromatosis (NF).
Amanjit Bahl +7 more
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Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li +13 more
wiley +1 more source
Malignant peripheral nerve sheath tumour: A rare tumour of the breast [PDF]
Malignant peripheral nerve sheath tumour is a rare tumour of the breast and this report highlights the radiological and histological features and the difficulties in making a diagnosis. A high index of suspicion when dealing with a breast lesion that has
Akhator, A +3 more
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